Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
GASTRIC CANCER	MONDO_0001056	MLN	Unknown	34594039	GWAS catalog	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +1 more
		MMP9	Unknown	34290314	GWAS catalog	Endocrine resistance IL-17 signaling pathway TNF signaling pathway +22 more
		MRTFA	Unknown	37340002	GWAS catalog	SUMOylation of transcription cofactors RHO GTPases Activate Formins
		MTAP	Unknown	27197191	GWAS catalog	Cysteine and methionine metabolism Metabolic pathways Methionine salvage pathway +1 more
		MTX1	Unknown	27197191 31383772 32514122 34594039 37209533 37340002	GWAS catalog	Mitophagy - animal
		MUC1	Unknown	26129866	GWAS catalog	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +4 more
		MYCBP2	Unknown	39862296	GWAS catalog	—
		MYL12BP2	Unknown	33002439	GWAS catalog	—
		MYO9B	Unknown	34290314	GWAS catalog	Motor proteins Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation +2 more
		NCOA6	Unknown	34290314	GWAS catalog	RORA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis +4 more
		NHLRC1	Unknown	29299148	GWAS catalog	Ubiquitin mediated proteolysis Glycogen synthesis Myoclonic epilepsy of Lafora
		NPIPB2	Unknown	32671202	GWAS catalog	—
		NSUN3	Unknown	31383772	GWAS catalog	—
		NTM	Unknown	35325318	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		NXPH1	Unknown	39024449	GWAS catalog	—
		OARD1	Unknown	26129866	GWAS catalog	—
		OCA2	Unknown	34290314	GWAS catalog	Melanin biosynthesis
		OPCML	Unknown	26129866	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		OR6C6	Unknown	29299148	GWAS catalog	Olfactory transduction Olfactory Signaling Pathway
		PADI6	Unknown	34290314	GWAS catalog	Chromatin modifying enzymes
		PARD3B	Unknown	39862296	GWAS catalog	—
		PCDHGA1	Unknown	37340842	GWAS catalog	—
		PDK1	Unknown	39408230	GWAS catalog	HIF-1 signaling pathway Central carbon metabolism in cancer Regulation of pyruvate dehydrogenase (PDH) complex +1 more
		PGBD1	Unknown	33002439	GWAS catalog	—
		PHF20	Unknown	34290314	GWAS catalog	HATs acetylate histones Regulation of TP53 Degradation Regulation of TP53 Activity through Association with Co-factors +1 more
		PIGU	Unknown	34290314	GWAS catalog	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways Attachment of GPI anchor to uPAR
		PLCE1	Unknown	31383772 33002439	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Ras signaling pathway +9 more
		POU2AF3	Unknown	37340002	GWAS catalog	—
		POU5F1B	Unknown	34290314 37340002	GWAS catalog	Signaling pathways regulating pluripotency of stem cells
		PPP1R10	Unknown	33002439	GWAS catalog	—
		PRKAA1	Unknown	22037551 26129866 30281874 33002439 37340002	GWAS catalog	FoxO signaling pathway Autophagy - animal mTOR signaling pathway +21 more
		PRMT6	Unknown	37340002	GWAS catalog	RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
		PRPS1L1	Unknown	33002439	GWAS catalog	Pentose phosphate pathway Purine metabolism Metabolic pathways +3 more
		PRXL2C	Unknown	37340842	GWAS catalog	—
		PSCA	Unknown	26098866 30189721 30281874 32514122 33002439 34290314 34594039 37209533 37340002 37340842	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		PTGER4	Unknown	26098866	GWAS catalog	Neuroactive ligand-receptor interaction Efferocytosis Inflammatory mediator regulation of TRP channels +7 more
		PXYLP1	Unknown	39862296	GWAS catalog	—
		RAD51B	Unknown	34290314	GWAS catalog	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		RALY	Unknown	27197191 33893285 34290314	GWAS catalog	—
		RANBP6	Unknown	33002439	GWAS catalog	—
		RBM25	Unknown	34290314	GWAS catalog	Spliceosome
		RCC2	Unknown	33893285	GWAS catalog	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion +3 more
		RCCD1	Unknown	37340002	GWAS catalog	—
		RGS22	Unknown	34290314	GWAS catalog	—
		RHOU	Unknown	34290314	GWAS catalog	Rho GTPase cycle Interleukin-4 and Interleukin-13 signaling
		RNF19A	Unknown	34290314	GWAS catalog	Antigen processing: Ubiquitination & Proteasome degradation
		RNF43	Unknown	39862296	GWAS catalog	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		SCEL	Unknown	39862296	GWAS catalog	—
		SEPTIN4	Unknown	34290314	GWAS catalog	Apoptosis Apoptosis - multiple species Release of apoptotic factors from the mitochondria +1 more
		SGCG	Unknown	35325318	GWAS catalog	Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy +2 more
GASTRIC CARCINOMA	EFO_0000178	MLN	Unknown	34594039	GWAS catalog	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +1 more
		MTX1	Unknown	31383772 32514122 34594039 37209533 37340002	GWAS catalog	Mitophagy - animal
		MUC1	Unknown	20729852 26129866 26701879	GWAS catalog	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +4 more
		MYCBP2	Unknown	39862296	GWAS catalog	—
		MYL12BP2	Unknown	33002439	GWAS catalog	—
		NPIPB2	Unknown	32671202	GWAS catalog	—
		NSUN3	Unknown	31383772	GWAS catalog	—
		NTM	Unknown	35325318	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		OARD1	Unknown	26129866	GWAS catalog	—
		OPCML	Unknown	26129866	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		PARD3B	Unknown	39862296	GWAS catalog	—
		PCDHGA1	Unknown	37340842	GWAS catalog	—
		PDK1	Unknown	39408230	GWAS catalog	HIF-1 signaling pathway Central carbon metabolism in cancer Regulation of pyruvate dehydrogenase (PDH) complex +1 more
		PGBD1	Unknown	33002439	GWAS catalog	—
		PLCE1	Unknown	20729852 31383772 33002439	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Ras signaling pathway +9 more
		PPP1R10	Unknown	33002439	GWAS catalog	—
		PRKAA1	Unknown	22037551 26129866 26701879 30281874 33002439 37340002	GWAS catalog	FoxO signaling pathway Autophagy - animal mTOR signaling pathway +21 more
		PRPS1L1	Unknown	33002439	GWAS catalog	Pentose phosphate pathway Purine metabolism Metabolic pathways +3 more
		PRXL2C	Unknown	37340842	GWAS catalog	—
		PSCA	Unknown	26098866 26701879 30189721 30281874 32514122 33002439 34594039 37209533 37340002 37340842	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		PTGER4	Unknown	26098866	GWAS catalog	Neuroactive ligand-receptor interaction Efferocytosis Inflammatory mediator regulation of TRP channels +7 more
		PXYLP1	Unknown	39862296	GWAS catalog	—
		RANBP6	Unknown	33002439	GWAS catalog	—
		RNF43	Unknown	39862296	GWAS catalog	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		SCEL	Unknown	39862296	GWAS catalog	—

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Gastric cancer

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