Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
GASTRIC CANCER	613659 MONDO:0001056 MONDO_0001056	APC	Causal	15457249 3034404 25820570 7773929 17344846 15273732 11973654 15824733 14534542 10395927 9679752	ClinVar, HPO	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		BRCA2	Causal	27197191 34290314	GWAS catalog	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		CASP10	Causal	3034404 7773929 17344846 15824733 14534542 15457249 25820570 10395927 11973654 9679752 15273732	ClinVar, HPO	Apoptosis RIG-I-like receptor signaling pathway TNF signaling pathway +6 more
		ERBB2	Causal	15457249 15824733 14534542 7773929 17344846 15273732 25820570 11973654 10395927 3034404 9679752	ClinVar, HPO	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		FANCA	Causal	33893285 34290314	GWAS catalog	Fanconi anemia pathway Fanconi Anemia Pathway
		FGFR2	Causal	34290314 37340002	ClinVar, GWAS catalog, HPO	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		HOXB13	Causal	34290314	GWAS catalog	—
		IRF1	Causal	11973654 15273732 25820570 7773929 17344846 14534542 15457249 9679752 3034404 10395927 15824733	ClinVar, HPO	C-type lectin receptor signaling pathway TNF signaling pathway Prolactin signaling pathway +5 more
		KLF6	Causal	3034404 7773929 10395927 15824733 11973654 15273732 25820570 17344846 14534542 15457249 9679752	ClinVar, HPO	—
		KRAS	Causal	14534542 3034404 17344846 7773929 25820570 15273732 15457249 9679752 11973654 15824733 10395927	ClinVar, HPO	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		MUTYH	Causal	15273732 9679752 3034404 10395927 11973654 15457249 15824733 25820570 7773929 17344846 14534542	ClinVar, HPO	Base excision repair Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine +2 more
		PALB2	Causal	34290314	GWAS catalog	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +3 more
		PIK3CA	Causal	—	ClinVar, HPO	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		TP53	Causal	28346444	GWAS catalog	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		ABLIM2	Unknown	35325318	GWAS catalog	Axon guidance
		ABO	Unknown	30281874 37209533 37340002	GWAS catalog	Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - globo and isoglobo series Metabolic pathways +1 more
		ADAMTS18	Unknown	39862296	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ALK	Unknown	37209533	GWAS catalog	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		ANKRD11	Unknown	34290314	GWAS catalog	—
		ARC	Unknown	33002439 37340842	GWAS catalog	Amphetamine addiction NGF-stimulated transcription
		ARHGEF10L	Unknown	33893285	GWAS catalog	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ASB3	Unknown	35121771	GWAS catalog	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		ASIP	Unknown	27197191 34290314	GWAS catalog	Melanogenesis
		ATF7IP	Unknown	39024449	GWAS catalog	PKMTs methylate histone lysines
		ATXN2	Unknown	27197191 34290314	GWAS catalog	Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases
		ATXN7L1	Unknown	39862296	GWAS catalog	—
		AZGP1	Unknown	37340002	GWAS catalog	Miscellaneous transport and binding events
		BABAM1	Unknown	27197191	GWAS catalog	Homologous recombination Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +3 more
		BAD	Unknown	34290314	GWAS catalog	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +44 more
		BCL2L11	Unknown	34290314	GWAS catalog	EGFR tyrosine kinase inhibitor resistance FoxO signaling pathway PI3K-Akt signaling pathway +13 more
		BNC2	Unknown	33893285	GWAS catalog	—
		BPIFA3	Unknown	34290314	GWAS catalog	—
		C11ORF65	Unknown	34290314	GWAS catalog	—
		C6ORF118	Unknown	39862296	GWAS catalog	—
		C7	Unknown	33002439	GWAS catalog	Complement and coagulation cascades Regulation of actin cytoskeleton Prion disease +4 more
		CASP8	Unknown	33893285 34290314	GWAS catalog	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CCDC170	Unknown	37340002	GWAS catalog	—
		CCDC32	Unknown	33002439	GWAS catalog	—
		CDH13	Unknown	39862296	GWAS catalog	Adherens junctions interactions
		CDK5RAP1	Unknown	34290314	GWAS catalog	—
		CELF2	Unknown	34290314	GWAS catalog	—
		CELSR1	Unknown	39862296	GWAS catalog	—
		CERS2	Unknown	34290314	GWAS catalog	Sphingolipid metabolism Metabolic pathways Sphingolipid signaling pathway +1 more
		CHLSN	Unknown	35325318	GWAS catalog	—
		CHMP4B	Unknown	34290314	GWAS catalog	Viral life cycle - HIV-1 Virion - Hepatitis viruses Endocytosis +6 more
		CHST14	Unknown	33002439	GWAS catalog	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Dermatan sulfate biosynthesis Defective CHST14 causes EDS, musculocontractural type
		CLK1	Unknown	34290314	GWAS catalog	Legionellosis
		CSMD1	Unknown	39408230	GWAS catalog	—
		CTNND2	Unknown	39862296	GWAS catalog	Wnt signaling pathway
		CUX2	Unknown	30281874	GWAS catalog	—
GASTRIC CARCINOMA	EFO_0000178	ABLIM2	Unknown	35325318	GWAS catalog	Axon guidance
		ABO	Unknown	30281874 37209533 37340002	GWAS catalog	Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - globo and isoglobo series Metabolic pathways +1 more
		ADAMTS18	Unknown	39862296	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ALK	Unknown	37209533	GWAS catalog	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		ARC	Unknown	33002439 37340842	GWAS catalog	Amphetamine addiction NGF-stimulated transcription
		ASB3	Unknown	35121771	GWAS catalog	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		ATXN7L1	Unknown	39862296	GWAS catalog	—
		C6ORF118	Unknown	39862296	GWAS catalog	—
		C7	Unknown	33002439	GWAS catalog	Complement and coagulation cascades Regulation of actin cytoskeleton Prion disease +4 more
		CCDC32	Unknown	33002439	GWAS catalog	—
		CDH13	Unknown	39862296	GWAS catalog	Adherens junctions interactions
		CELSR1	Unknown	39862296	GWAS catalog	—
		CHLSN	Unknown	35325318	GWAS catalog	—
		CHST14	Unknown	33002439	GWAS catalog	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Dermatan sulfate biosynthesis Defective CHST14 causes EDS, musculocontractural type
		CSMD1	Unknown	39408230	GWAS catalog	—
		CTNND2	Unknown	39862296	GWAS catalog	Wnt signaling pathway
		CUX2	Unknown	30281874	GWAS catalog	—

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Gastric cancer

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