Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
gastroesophageal junction adenocarcinoma	MONDO_0003219	STK11	Unknown	28481359	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		STRN	Unknown	23525077	Open Targets	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +2 more
		SYK	Unknown	29703791 24308032	Open Targets	NF-kappa B signaling pathway Phospholipase D signaling pathway PI3K-Akt signaling pathway +30 more
		TAL1	Unknown	29703791	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs
		TBX3	Unknown	29703791 28481359	Open Targets	Signaling pathways regulating pluripotency of stem cells
		TCF12	Unknown	24308032	Open Targets	Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription
		TCF3	Unknown	29703791	Open Targets	Signaling pathways regulating pluripotency of stem cells Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer +2 more
		TCF7L2	Unknown	23525077 29703791	Open Targets	Wnt signaling pathway Hippo signaling pathway Adherens junction +26 more
		TCL1A	Unknown	24308032	Open Targets	PI3K-Akt signaling pathway
		TEC	Unknown	23525077	Open Targets	Osteoclast differentiation T cell receptor signaling pathway Signaling by SCF-KIT +2 more
		TENT5C	Unknown	29703791	Open Targets	—
		TET1	Unknown	23525077 28481359	Open Targets	—
		TET2	Unknown	28481359	Open Targets	—
		TFE3	Unknown	29703791	Open Targets	Mitophagy - animal Transcriptional misregulation in cancer Renal cell carcinoma
		TFEB	Unknown	29703791 24308032	Open Targets	Calcium signaling pathway Mitophagy - animal
		TFG	Unknown	23525077 29703791 24308032	Open Targets	Pathways in cancer Thyroid cancer COPII-mediated vesicle transport
		TFPT	Unknown	29703791	Open Targets	ATP-dependent chromatin remodeling UCH proteinases DNA Damage Recognition in GG-NER
		TFRC	Unknown	29703791	Open Targets	Virion - Lassa virus and SFTS virus HIF-1 signaling pathway Endocytosis +8 more
		TGFBR2	Unknown	29703791 23525077 22484628 28481359	Open Targets	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +28 more
		THRAP3	Unknown	29703791 24308032	Open Targets	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation
		TLX1	Unknown	29703791	Open Targets	Transcriptional misregulation in cancer
		TLX3	Unknown	29703791	Open Targets	Transcriptional misregulation in cancer
		TNC	Unknown	23525077 29703791 22484628	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +6 more
		TNFAIP3	Unknown	23525077 29703791	Open Targets	NF-kappa B signaling pathway Necroptosis NOD-like receptor signaling pathway +10 more
		TNFRSF14	Unknown	23525077	Open Targets	Virion - Herpesvirus Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +3 more
		TNRC18	Unknown	23525077 29703791	Open Targets	—
		TOP1	Unknown	28481359	Open Targets	SUMOylation of DNA replication proteins
		TP53	Unknown	27588476 22484628 29703791 24308032 23525077 25656989 28859360 37107676 27566247 29420467 28481359 28376920	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TP63	Unknown	23525077	Open Targets	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TPM3	Unknown	29703791 24308032	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +7 more
		TPR	Unknown	23525077 24308032	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer +27 more
		TRAF7	Unknown	23525077	Open Targets	Antigen processing: Ubiquitination & Proteasome degradation
		TRIM27	Unknown	24308032	Open Targets	SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis
		TRIM33	Unknown	29703791	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity
		TRIP11	Unknown	29703791 24308032	Open Targets	Intraflagellar transport Intra-Golgi traffic
		TRRAP	Unknown	23525077 29703791	Open Targets	ATP-dependent chromatin remodeling Human T-cell leukemia virus 1 infection Formation of the beta-catenin:TCF transactivating complex +1 more
		TSC1	Unknown	28481359 24308032	Open Targets	Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway +15 more
		TSC2	Unknown	28481359 29703791 24308032	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		TSHR	Unknown	24308032	Open Targets	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
		U2AF1	Unknown	28481359	Open Targets	Spliceosome Shigellosis Transport of Mature mRNA derived from an Intron-Containing Transcript +3 more
		UBR5	Unknown	29703791 24308032	Open Targets	Ubiquitin mediated proteolysis
		USP44	Unknown	29703791	Open Targets	Ub-specific processing proteases
		USP6	Unknown	23525077 29703791 24308032	Open Targets	—
		VAV1	Unknown	23525077 29703791	Open Targets	Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway +30 more
		WNK2	Unknown	29703791 24308032	Open Targets	Parathyroid hormone synthesis, secretion and action Stimuli-sensing channels
		WRN	Unknown	24308032	Open Targets	Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins +9 more
		WT1	Unknown	23525077 29703791 29420467 24308032 28481359	Open Targets	Transcriptional misregulation in cancer
		XPC	Unknown	23525077	Open Targets	Nucleotide excision repair SUMOylation of DNA damage response and repair proteins DNA Damage Recognition in GG-NER +1 more
		XPO1	Unknown	24308032	Open Targets	Ribosome biogenesis in eukaryotes Nucleocytoplasmic transport Viral life cycle - HIV-1 +15 more
		YAP1	Unknown	29703791 28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Nuclear signaling by ERBB4 +5 more

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Gastresophageal junction adenocarcinoma

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