Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
gallbladder adenoma	MONDO_0006216	HIP1	Unknown	34362903	Open Targets	Huntington disease Pathways of neurodegeneration - multiple diseases Clathrin-mediated endocytosis
		HOXC13	Unknown	34362903	Open Targets	—
		KDM5C	Unknown	34362903	Open Targets	HDMs demethylate histones
		KDR	Unknown	34362903	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KMT2A	Unknown	34362903	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	34362903	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KRAS	Unknown	10364037 9356872 26421956 8194013 7926462 29975247 18182852 9923922 21307665	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LARP4B	Unknown	34362903	Open Targets	—
		LPP	Unknown	34362903	Open Targets	—
		LZTR1	Unknown	34362903	Open Targets	—
		MAX	Unknown	34362903	Open Targets	Polycomb repressive complex MAPK signaling pathway Pathways in cancer +6 more
		MED12	Unknown	34362903	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MLLT10	Unknown	34362903	Open Targets	—
		MSH6	Unknown	34362903	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MTOR	Unknown	34362903	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MUC16	Unknown	34362903	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	34362903	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MYB	Unknown	34362903	Open Targets	PI3K-Akt signaling pathway RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression
		MYH9	Unknown	34362903	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +8 more
		NBEA	Unknown	34362903	Open Targets	—
		NCOA2	Unknown	34362903	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway RORA activates gene expression +14 more
		NF1	Unknown	34362903	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NFE2L2	Unknown	34362903	Open Targets	Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer +4 more
		NIN	Unknown	34362903	Open Targets	—
		NKX2-1	Unknown	34362903	Open Targets	—
		NOTCH2	Unknown	34362903	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NRG1	Unknown	34362903	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis +18 more
		NSD2	Unknown	34362903	Open Targets	Lysine degradation Metabolic pathways Transcriptional misregulation in cancer +5 more
		NTRK3	Unknown	34362903	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		PABPC1	Unknown	34362903	Open Targets	mRNA surveillance pathway RNA degradation L13a-mediated translational silencing of Ceruloplasmin expression +5 more
		PALB2	Unknown	34362903	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +3 more
		PAX7	Unknown	34362903	Open Targets	Transcriptional misregulation in cancer
		PBRM1	Unknown	34362903	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		PBX1	Unknown	34362903	Open Targets	Efferocytosis Cortisol synthesis and secretion Cushing syndrome +3 more
		PDE4DIP	Unknown	34362903	Open Targets	—
		PDGFRB	Unknown	34362903	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PIK3CA	Unknown	34362903	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3CB	Unknown	34362903	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +126 more
		PLCG1	Unknown	34362903	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +70 more
		PLEC	Unknown	34362903	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		POLG	Unknown	34362903	Open Targets	Base excision repair
		POLQ	Unknown	34362903	Open Targets	HDR through MMEJ (alt-NHEJ)
		PRCC	Unknown	34362903	Open Targets	Transcriptional misregulation in cancer Renal cell carcinoma mRNA Splicing - Major Pathway
		PRDM2	Unknown	34362903	Open Targets	Lysine degradation Metabolic pathways
		PREX2	Unknown	34362903	Open Targets	Regulation of PTEN stability and activity
		PSIP1	Unknown	34362903	Open Targets	Viral life cycle - HIV-1 Integration of provirus 2-LTR circle formation +4 more
		PTPN13	Unknown	34362903	Open Targets	Apoptosis Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
		PTPRB	Unknown	34362903	Open Targets	Adherens junction Neutrophil degranulation
		RBM10	Unknown	34362903	Open Targets	—
		RECQL4	Unknown	34362903	Open Targets	—

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Gallbladder adenoma

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