Subtype of: Thyroid carcinoma · Thyroid neoplasms

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
follicular variant thyroid gland papillary carcinoma	MONDO_0006214	ALK	Unknown	24475247	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		APC	Unknown	26971368 34680332	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		ARID1B	Unknown	34680332	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ATM	Unknown	34680332	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		BRAF	Unknown	20009493 23690118 19208736 23590130 25024077 21498916 23979959 16452550 20543822 22007921 20042852 23192464 21167555 19393416 29085338 16932068 19414674 23571588 16753739 22156468 17308360 20471663 22150560 16784981 22504197 22105775 16174717 18310286 24909403 20631031 20860430 19200582 28975450 15735849 30361901 23966419 18070147 20526288 20854070 25120313 20564403 15356022 17542667 26366474 18363883 18393366 21803329 21609347 19370505 24402044 16728576 22190222 20186005 18840924 16676402 17727338 22925390 16434896 27717198 23580256 22431868 21948220 19765726 23534744 24449679 15356020 25702102 16728573 24777145 15102681 20447069 23280049 24721322 17535994 21716161 23595630 19152441 25317411 24862939 19658182 20703476 22358007 23888303 22156467 22918165 15714593 17785355 21385081 15472223 29435002 21774961 22426956 23607002 20460314 14743508 23482591 15687339 21909080 17717450 19738460 23837025 21431280 15807885 21796448 23775008 22249628 23881852 19253367 17824790 19574281 23625203 21875464 16181240 22081104 20950194 19355825 20702649 15980887 23179992 23163107 18310288 25648502 19958951 28502101 35154635 23476074 23157614 18710471 23323230 19269016 16601293 23062653 21134544	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		CCDC6	Unknown	20099311 22961909 21498916 17786355 20564403 20447069 22895275 16595592 18393128 24503805 20703476 22481925 9935226 24915144 24277231 11786418 23436219 16784981 15788648 17727338 19958951 26971368 16015630 9669285	Open Targets	Pathways in cancer Thyroid cancer
		DICER1	Unknown	26983701 34237031 29395683 24617712	Open Targets	MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
		EGFR	Unknown	19253367	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		ERBB2	Unknown	34680332	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ETV6	Unknown	26366474	Open Targets	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		FLT4	Unknown	34680332	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		GOLGA5	Unknown	11786418	Open Targets	Intra-Golgi traffic
		HIF1A	Unknown	34680332	Open Targets	HIF-1 signaling pathway Mitophagy - animal Autophagy - animal +19 more
		HRAS	Unknown	25648502 17651453 23625203 23888303 28975450 35716104 23590130 28502101 29085338 20526288 16784981 34680332 17786355 23477374 9724079 12866375 18310288	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		IDH1	Unknown	20702649	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IDH2	Unknown	37760447	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		JAK2	Unknown	26971368	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		KEAP1	Unknown	29469959	Open Targets	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KIT	Unknown	26971368	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KRAS	Unknown	25648502 23625203 23590130 19809427 18070147 20526288 29085338	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		KTN1	Unknown	11786418	Open Targets	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
		LRP1B	Unknown	34680332	Open Targets	—
		NCOA4	Unknown	20099311 22961909 21498916 17786355 20564403 20447069 22895275 16595592 8806700 18393128 24503805 20703476 22481925 9935226 24915144 24277231 11786418 23436219 16784981 15788648 17727338 19958951 26971368 16015630 9669285	Open Targets	Ferroptosis Pathways in cancer Thyroid cancer
		NRAS	Unknown	17651453 28975450 30361901 21796448 23590130 35716104 22961909 18070147 20526288 17786355 24834793 27824297 20564403 25427145 21216781 23625203 22081104 29085338 12866375 23477374 23888303 20702649 24277231 24798740 19809427 16784981 19913280 34680332 18310288 25648502 27717198 26971368 28502101 35154635 37760447	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NTRK1	Unknown	16483615 10074915	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NTRK3	Unknown	26366474	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		NUP98	Unknown	34680332	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		PAX8	Unknown	16728576 26366474 22895275 24915144 24277231 20099311 22961909 12161538 16086077 19963130 20089614 20526288 23436219 23993207 23881852 12866375 20564403	Open Targets	Thyroid hormone synthesis Pathways in cancer Transcriptional misregulation in cancer +1 more
		PPARG	Unknown	16728576 26366474 22895275 24915144 24277231 20099311 22961909 12161538 16086077 19963130 20089614 20526288 23436219 23993207 23881852 12866375 20564403	Open Targets	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
		PRKAR1A	Unknown	9935226 20447069 24277231 11786418 9669285 18393128 22481925	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		PTPN11	Unknown	26971368	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		RET	Unknown	20099311 22961909 21498916 17786355 20564403 12787916 20447069 22895275 16595592 8806700 18393128 24503805 20703476 22481925 9935226 24915144 24277231 11786418 23436219 16784981 15788648 17727338 19958951 26971368 16015630 9669285	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		SMAD4	Unknown	26971368	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SPOP	Unknown	34680332	Open Targets	Hedgehog signaling pathway Hedgehog 'on' state
		STRN	Unknown	24475247	Open Targets	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +2 more
		TFG	Unknown	16483615 10074915	Open Targets	Pathways in cancer Thyroid cancer COPII-mediated vesicle transport
		TPM3	Unknown	16483615 10074915	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +7 more
		TPR	Unknown	16483615 10074915	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer +27 more
		TRIM24	Unknown	11786418	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF fusions
		TRIM27	Unknown	12787916	Open Targets	SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis
		TRIM33	Unknown	11786418	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity
		TSC1	Unknown	34680332	Open Targets	Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway +15 more
		TSC2	Unknown	34680332	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		VHL	Unknown	23477374	Open Targets	HIF-1 signaling pathway Ubiquitin mediated proteolysis Pathways in cancer +5 more
		ZFHX3	Unknown	34680332	Open Targets	Signaling pathways regulating pluripotency of stem cells RUNX3 regulates CDKN1A transcription

Follicular variant thyroid gland papillary carcinoma

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