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Familial ovarian cancer
Familial ovarian cancer
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Include the contents of this disease's 3 subtypes
in the table below
Show the subtypes
Breast-ovarian cancer, familial, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 4
Hereditary breast and ovarian cancer syndrome
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Pathways column key:
KEGG
Reactome
Disease Term
Disease ID
Gene Symbol
Classification
References
Source
Pathways
familial ovarian cancer
MONDO_0003582
BRCA1
Unknown
23788249
29661970
20513136
8968716
12938098
28364669
14722926
17924331
9760198
Open Targets
Platinum drug resistance
Homologous recombination
Fanconi anemia pathway
Ubiquitin mediated proteolysis
PI3K-Akt signaling pathway
MicroRNAs in cancer
Breast cancer
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Transcriptional Regulation by E2F6
+19 more
BRCA2
Unknown
29661970
Open Targets
Homologous recombination
Fanconi anemia pathway
Pathways in cancer
Pancreatic cancer
Breast cancer
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange
+7 more
PALB2
Unknown
24556926
31841383
17200668
18053174
23448497
Open Targets
Homologous recombination
Fanconi anemia pathway
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
+3 more
All
6
Causal
3
Unknown
3
Select all
Clear
ClinVar
0
Orphanet
0
Disgenet
0
CTD
0
HPO
0
GWAS catalog
0
GenCC
0
ClinGen
0
Open Targets
3
Related Diseases
Diseases that share the most curated genes with Familial ovarian cancer.
5
View disease cluster →
Cancer predisposition
5 shared genes
PALB2, BRCA2, BRCA1, RAD51C, RAD51D
Related via 5 shared genes including PALB2, BRCA2, BRCA1.
Hereditary breast and ovarian cancer syndrome
6 shared genes
PALB2, BRCA2, BRIP1, BRCA1, RAD51C, RAD51D
Related via 6 shared genes including PALB2, BRCA2, BRIP1.
Breast implant-associated anaplastic large cell lymphoma
2 shared genes
BRCA2, BRCA1
Related via 2 shared genes including BRCA2, BRCA1.
Fanconi anemia complementation group n
1 shared gene
PALB2
Related via 1 shared gene including PALB2.
Bone marrow failure
4 shared genes
PALB2, BRCA2, BRCA1, RAD51C
Related via 4 shared genes including PALB2, BRCA2, BRCA1.
1
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