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Familial ovarian cancer
Familial ovarian cancer
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Include the contents of this disease's 3 subtypes
in the table below
Show the subtypes
Breast-ovarian cancer, familial, susceptibility to, 3
Breast-ovarian cancer, familial, susceptibility to, 4
Hereditary breast and ovarian cancer syndrome
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Pathways column key:
KEGG
Reactome
Disease Term
Disease ID
Gene Symbol
Classification
References
Source
Pathways
familial ovarian cancer
MONDO_0016248
MONDO_0003582
BRIP1
Causal
26315354
29661970
21964575
31822495
ClinGen
,
Open Targets
Homologous recombination
Fanconi anemia pathway
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
+8 more
RAD51C
Causal
21990120
20400964
24141787
Open Targets
Homologous recombination
Fanconi anemia pathway
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange
Factors involved in megakaryocyte development and platelet production
+5 more
RAD51D
Causal
21822267
Open Targets
Homologous recombination
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
+4 more
All
6
Causal
3
Unknown
3
Select all
Clear
ClinVar
0
Orphanet
0
Disgenet
0
CTD
0
HPO
0
GWAS catalog
0
GenCC
0
ClinGen
1
Open Targets
3
Related Diseases
Diseases that share the most curated genes with Familial ovarian cancer.
5
View disease cluster →
Cancer predisposition
5 shared genes
PALB2, BRCA2, BRCA1, RAD51C, RAD51D
Related via 5 shared genes including PALB2, BRCA2, BRCA1.
Hereditary breast and ovarian cancer syndrome
6 shared genes
PALB2, BRCA2, BRIP1, BRCA1, RAD51C, RAD51D
Related via 6 shared genes including PALB2, BRCA2, BRIP1.
Breast implant-associated anaplastic large cell lymphoma
2 shared genes
BRCA2, BRCA1
Related via 2 shared genes including BRCA2, BRCA1.
Fanconi anemia complementation group n
1 shared gene
PALB2
Related via 1 shared gene including PALB2.
Bone marrow failure
4 shared genes
PALB2, BRCA2, BRCA1, RAD51C
Related via 4 shared genes including PALB2, BRCA2, BRCA1.
1
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