Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
ESOPHAGEAL CANCER	MONDO_0007576 133239	HLA-B	Unknown	27197191	GWAS catalog	Endocytosis Phagosome Cellular senescence +24 more
		HLA-DQB1	Unknown	27197191 33893285 34290314 37340002	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DRA	Unknown	34290314	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HNF1B	Unknown	27197191 37340002	GWAS catalog	Maturity onset diabetes of the young
		HOXB13	Unknown	34290314	GWAS catalog	—
		IFT81	Unknown	34594039	GWAS catalog	Intraflagellar transport
		IGF2BP2	Unknown	37340002	GWAS catalog	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
		IRF4	Unknown	33893285 34290314	GWAS catalog	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		JRK	Unknown	34290314 37340002	GWAS catalog	—
		KCNH1	Unknown	27197191	GWAS catalog	Voltage gated Potassium channels
		KCNQ1	Unknown	37340002	GWAS catalog	Adrenergic signaling in cardiomyocytes Cholinergic synapse Gastric acid secretion +6 more
		KIF20B	Unknown	37340002	GWAS catalog	Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins
		KRT5	Unknown	34290314	GWAS catalog	Type I hemidesmosome assembly Keratinization Formation of the cornified envelope
		LCTL	Unknown	34290314	GWAS catalog	—
		LDLRAD4	Unknown	34290314	GWAS catalog	—
		LRFN2	Unknown	21642993	GWAS catalog	Synaptic adhesion-like molecules
		LRRIQ4	Unknown	34290314	GWAS catalog	—
		LY6K	Unknown	37340002	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		LZTS1	Unknown	—	HPO	—
		MAP3K1	Unknown	37340002	GWAS catalog	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MCL1	Unknown	34290314	GWAS catalog	PI3K-Akt signaling pathway Apoptosis JAK-STAT signaling pathway +2 more
		MECOM	Unknown	27197191	GWAS catalog	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
		MLC1	Unknown	34290314	GWAS catalog	—
		MMP9	Unknown	34290314	GWAS catalog	Endocrine resistance IL-17 signaling pathway TNF signaling pathway +22 more
		MRTFA	Unknown	37340002	GWAS catalog	SUMOylation of transcription cofactors RHO GTPases Activate Formins
		MTAP	Unknown	27197191	GWAS catalog	Cysteine and methionine metabolism Metabolic pathways Methionine salvage pathway +1 more
		MTX1	Unknown	27197191	GWAS catalog	Mitophagy - animal
		MYO9B	Unknown	34290314	GWAS catalog	Motor proteins Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation +2 more
		NAALADL2	Unknown	21642993	GWAS catalog	—
		NCOA6	Unknown	34290314	GWAS catalog	RORA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis +4 more
		NHLRC1	Unknown	29299148	GWAS catalog	Ubiquitin mediated proteolysis Glycogen synthesis Myoclonic epilepsy of Lafora
		OCA2	Unknown	34290314	GWAS catalog	Melanin biosynthesis
		OR6C6	Unknown	29299148	GWAS catalog	Olfactory transduction Olfactory Signaling Pathway
		PADI6	Unknown	34290314	GWAS catalog	Chromatin modifying enzymes
		PALB2	Unknown	34290314	GWAS catalog	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +3 more
		PDE4D	Unknown	21642993	GWAS catalog	Purine metabolism Metabolic pathways cAMP signaling pathway +4 more
		PHF20	Unknown	34290314	GWAS catalog	HATs acetylate histones Regulation of TP53 Degradation Regulation of TP53 Activity through Association with Co-factors +1 more
		PIGU	Unknown	34290314	GWAS catalog	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways Attachment of GPI anchor to uPAR
		PLCE1	Unknown	21642993	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Ras signaling pathway +9 more
		POU2AF3	Unknown	37340002	GWAS catalog	—
		POU5F1B	Unknown	34290314 37340002	GWAS catalog	Signaling pathways regulating pluripotency of stem cells
		PRMT6	Unknown	37340002	GWAS catalog	RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
		PSCA	Unknown	34290314 37340002	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		RAD51B	Unknown	34290314	GWAS catalog	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		RALY	Unknown	27197191 33893285 34290314	GWAS catalog	—
		RASSF10	Unknown	34594039	GWAS catalog	—
		RBM25	Unknown	34290314	GWAS catalog	Spliceosome
		RCC2	Unknown	33893285	GWAS catalog	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion +3 more
		RCCD1	Unknown	37340002	GWAS catalog	—
		RGS22	Unknown	34290314	GWAS catalog	—
ESOPHAGEAL CARCINOMA	EFO_0002916	IFT81	Unknown	34594039	GWAS catalog	Intraflagellar transport
		LRFN2	Unknown	21642993	GWAS catalog	Synaptic adhesion-like molecules
		NAALADL2	Unknown	21642993	GWAS catalog	—
		PDE4D	Unknown	21642993	GWAS catalog	Purine metabolism Metabolic pathways cAMP signaling pathway +4 more
		PLCE1	Unknown	20729852 21642993	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Ras signaling pathway +9 more
		RASSF10	Unknown	34594039	GWAS catalog	—
MALIGNANT TUMOR OF ESOPHAGUS		LZTS1	Unknown	12154016 10097140 19558548 10789724 10213508 11956080 17460548	ClinVar	—

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Esophageal cancer

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