Epilepsy

ABC transporters Bile secretion MicroRNAs in cancer Gastric cancer ABC-family proteins mediated transport +2 more

ABC transporters ATP sensitive Potassium channels ABC-family proteins mediated transport Ion homeostasis Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia +2 more

Glycerophospholipid metabolism Cholinergic synapse Neurotransmitter clearance Synthesis of PC Synthesis, secretion, and deacylation of Ghrelin +2 more

Tryptophan metabolism Metabolic pathways

Calcium signaling pathway cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction Hormone signaling AMPK signaling pathway Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Salivary secretion Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events +8 more

cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events G alpha (z) signalling events Surfactant metabolism +6 more

cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor G alpha (i) signalling events G alpha (z) signalling events +4 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway HIF-1 signaling pathway FoxO signaling pathway Sphingolipid signaling pathway Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Apoptosis Longevity regulating pathway Longevity regulating pathway - multiple species Cellular senescence Adrenergic signaling in cardiomyocytes VEGF signaling pathway Apelin signaling pathway Osteoclast differentiation Focal adhesion Signaling pathways regulating pluripotency of stem cells Platelet activation Neutrophil extracellular trap formation Toll-like receptor signaling pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis TNF signaling pathway Neurotrophin signaling pathway Cholinergic synapse Dopaminergic synapse Regulation of actin cytoskeleton Insulin signaling pathway Progesterone-mediated oocyte maturation Estrogen signaling pathway Prolactin signaling pathway Thyroid hormone signaling pathway Adipocytokine signaling pathway Glucagon signaling pathway Regulation of lipolysis in adipocytes Relaxin signaling pathway GnRH secretion Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Alcoholic liver disease Carbohydrate digestion and absorption Alzheimer disease Spinocerebellar ataxia Shigellosis Salmonella infection Yersinia infection Chagas disease Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Melanoma Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation mTOR signalling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network eNOS activation AKT-mediated inactivation of FOXO1A Integrin signaling Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling CTLA4 inhibitory signaling G beta:gamma signalling through PI3Kgamma Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RAB GEFs exchange GTP for GDP on RABs Regulation of PTEN stability and activity Extra-nuclear estrogen signaling Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling +131 more

Thyroid hormone synthesis Platelet degranulation Recycling of bile acids and salts Heme biosynthesis Heme degradation Scavenging of heme from plasma Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transport of organic anions Post-translational protein phosphorylation HDL remodeling +7 more

Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation Valine, leucine and isoleucine degradation Lysine degradation Arginine and proline metabolism Histidine metabolism Tryptophan metabolism beta-Alanine metabolism Glycerolipid metabolism Pyruvate metabolism Pantothenate and CoA biosynthesis Metabolic pathways Biosynthesis of cofactors Alcoholic liver disease Metabolism of serotonin Ethanol oxidation +14 more

N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) +2 more

NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events GABA receptor activation +1 more

ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known +2 more

Polycomb repressive complex

Efferocytosis Ion transport by P-type ATPases

Polycomb repressive complex RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Neurotransmitter clearance Synthesis of PC Synthesis, secretion, and deacylation of Ghrelin

MAPK signaling pathway Ras signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway Neurotrophin signaling pathway Huntington disease Pathways of neurodegeneration - multiple diseases Cocaine addiction Alcoholism Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through FRS2 and FRS3 NTRK2 activates RAC1 +9 more

Ras signaling pathway RAF activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants +3 more

MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Taste transduction Insulin secretion GnRH signaling pathway Oxytocin signaling pathway Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion GnRH secretion Type II diabetes mellitus Cushing syndrome Growth hormone synthesis, secretion and action Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Amphetamine addiction Chemical carcinogenesis - receptor activation Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase +34 more

MAPK signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Oxytocin signaling pathway Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Presynaptic depolarization and calcium channel opening Phase 0 - rapid depolarisation Phase 2 - plateau phase +7 more

Arginine biosynthesis Pyrimidine metabolism Alanine, aspartate and glutamate metabolism Metabolic pathways Biosynthesis of cofactors Pyrimidine biosynthesis +3 more

NOD-like receptor signaling pathway Parathyroid hormone synthesis, secretion and action G alpha (q) signalling events G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) +2 more

Neddylation

Sphingolipid de novo biosynthesis

Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction PI3K-Akt signaling pathway Cholinergic synapse Regulation of actin cytoskeleton Alzheimer disease Pathways of neurodegeneration - multiple diseases Muscarinic acetylcholine receptors G alpha (q) signalling events +7 more

Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction PI3K-Akt signaling pathway Cholinergic synapse Regulation of actin cytoskeleton Muscarinic acetylcholine receptors G alpha (i) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis +7 more

Calcium signaling pathway Neuroactive ligand-receptor interaction Cholinergic synapse Taste transduction Regulation of actin cytoskeleton Insulin secretion Salivary secretion Gastric acid secretion Pancreatic secretion Alzheimer disease Pathways of neurodegeneration - multiple diseases Muscarinic acetylcholine receptors G alpha (q) signalling events +10 more

Virion - Ebolavirus, Lyssavirus and Morbillivirus Neuroactive ligand-receptor interaction Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors +1 more

Calcium signaling pathway Neuroactive ligand-receptor interaction Cholinergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases Nicotine addiction Chemical carcinogenesis - receptor activation Highly calcium permeable postsynaptic nicotinic acetylcholine receptors +5 more

Mineral absorption Stimuli-sensing channels

Biosynthesis of various nucleotide sugars Metabolic pathways Biosynthesis of nucleotide sugars Sialic acid metabolism +1 more

Depolymerisation of the Nuclear Lamina

Cell adhesion molecules

Neutrophil degranulation

Oxidative phosphorylation Metabolic pathways Cardiac muscle contraction Thermogenesis Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy TP53 Regulates Metabolic Genes Respiratory electron transport +12 more

MAPK signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Oxytocin signaling pathway Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Presynaptic depolarization and calcium channel opening Phase 0 - rapid depolarisation Phase 2 - plateau phase +7 more

NOD-like receptor signaling pathway Parathyroid hormone synthesis, secretion and action G alpha (q) signalling events G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) +2 more

Mineral absorption Stimuli-sensing channels