Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
endometrium adenocarcinoma	MONDO_0005461	KIT	Unknown	27170661	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2A	Unknown	28485815	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	10767369 8600078 8428691 7856567 31412428 23733133 27170661 25997988 24811063 2064724 28481359 2205377	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LOC100506403	Unknown	28481359	Open Targets	—
		MAP2K2	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +87 more
		MAP2K4	Unknown	26373574	Open Targets	MAPK signaling pathway ErbB signaling pathway Toll-like receptor signaling pathway +21 more
		MED12	Unknown	28481359	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MET	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MLH1	Unknown	27302833 28481359	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MPL	Unknown	28481359	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		MSH2	Unknown	27302833 9071575 28481359 25194673	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MSH6	Unknown	27302833 23104009 11474654 12124347 26373574	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MTOR	Unknown	31412428 26373574 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MYCN	Unknown	26373574	Open Targets	Transcriptional misregulation in cancer
		MYD88	Unknown	33503190	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Toll-like receptor signaling pathway +39 more
		NCOR1	Unknown	28481359	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NF1	Unknown	27170661 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NOTCH1	Unknown	26373574 28481359	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NRAS	Unknown	31412428 27170661	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NSD1	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NTRK1	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NTRK2	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
		PAX5	Unknown	28481359	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PBRM1	Unknown	28481359	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		PDGFRA	Unknown	26373574	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		PIK3CA	Unknown	26492180 22696596 28485815 31412428 25588929 27170661 27302833 26373574 28481359 23733133	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3R1	Unknown	27170661 26373574 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PIK3R2	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +129 more
		POLD1	Unknown	28481359	Open Targets	DNA replication Base excision repair Nucleotide excision repair +19 more
		POLE	Unknown	28481359 26763250 25505230 25194673	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		PPP2R1A	Unknown	28481359 26492180 21381030 22653804 21435433	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PPP6C	Unknown	28481359	Open Targets	COPII-mediated vesicle transport
		PTCH1	Unknown	33503190 26373574	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	31412428 25588929 37848227 22498935 10955808 9865913 11849740 27302833 10657903 26373574 28481359 23733133	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		RB1	Unknown	31412428 26373574 28481359	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RET	Unknown	28481359	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		RICTOR	Unknown	28481359	Open Targets	mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling +3 more
		SETD2	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SMAD4	Unknown	26373574	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SMARCA4	Unknown	28481359	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMARCB1	Unknown	26373574	Open Targets	ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis +3 more
		SPOP	Unknown	28481359	Open Targets	Hedgehog signaling pathway Hedgehog 'on' state
		STAG2	Unknown	28481359	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STAT5B	Unknown	28481359	Open Targets	ErbB signaling pathway Chemokine signaling pathway Hormone signaling +28 more
		STK11	Unknown	28481359	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		SYK	Unknown	28481359	Open Targets	NF-kappa B signaling pathway Phospholipase D signaling pathway PI3K-Akt signaling pathway +30 more
		TBX3	Unknown	28481359	Open Targets	Signaling pathways regulating pluripotency of stem cells
		TET2	Unknown	28481359	Open Targets	—

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Endometrium adenocarcinoma

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