Subtype of: Endometrial cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
endometrial mixed adenocarcinoma	MONDO_0004321	JAK1	Unknown	28485815	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK2	Unknown	32404953	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		KDM5A	Unknown	28481359	Open Targets	HDMs demethylate histones
		KDM6A	Unknown	28485815	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KMT2C	Unknown	28485815 28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	28485815 28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	26975040 19839777 28481359 22653804 18500270	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LATS2	Unknown	28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LMNA	Unknown	28485815	Open Targets	Apoptosis Cytoskeleton in muscle cells Hypertrophic cardiomyopathy +8 more
		MAP2K2	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +87 more
		MAP3K1	Unknown	27566247 28481359	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MED12	Unknown	28485815 28481359	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MET	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MLH1	Unknown	28481359	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MTOR	Unknown	27566247	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MYC	Unknown	28481359	Open Targets	MAPK signaling pathway ErbB signaling pathway Cell cycle +45 more
		MYD88	Unknown	28481359	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Toll-like receptor signaling pathway +39 more
		NAB2	Unknown	28485815	Open Targets	NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
		NFKB2	Unknown	28485815	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation +19 more
		NOTCH1	Unknown	28485815	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NRAS	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NSD1	Unknown	28485815	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NTRK3	Unknown	28481359	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		PIK3CA	Unknown	26492180 18084252 28485815 32404953 22653804 19839777 28481359 22696596	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3R1	Unknown	26492180 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PMS1	Unknown	28485815	Open Targets	—
		POLD1	Unknown	28485815	Open Targets	DNA replication Base excision repair Nucleotide excision repair +19 more
		POLE	Unknown	27486176 26975040 26492180 28481359 26763250	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		PPP2R1A	Unknown	27566247 26492180 28481359 22653804	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PTEN	Unknown	11555573 26492180 28485815 26975040 28481359 12015762	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPRD	Unknown	28481359	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		RAD51C	Unknown	28481359	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +5 more
		RANBP2	Unknown	28485815	Open Targets	Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis +32 more
		RASA1	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more
		RICTOR	Unknown	28481359	Open Targets	mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling +3 more
		RNF213	Unknown	28485815	Open Targets	Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation
		RPL22	Unknown	28485815	Open Targets	Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression +7 more
		RPL5	Unknown	28485815	Open Targets	Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression +7 more
		SDHAF2	Unknown	28481359	Open Targets	—
		SETD2	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SMAD2	Unknown	28485815	Open Targets	Cell cycle Endocytosis Cellular senescence +30 more
		SMARCA4	Unknown	28481359	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMO	Unknown	28481359	Open Targets	Hedgehog signaling pathway Axon guidance Pathways in cancer +6 more
		SPOP	Unknown	26492180 28481359	Open Targets	Hedgehog signaling pathway Hedgehog 'on' state
		TBX3	Unknown	28481359	Open Targets	Signaling pathways regulating pluripotency of stem cells
		TERT	Unknown	28481359	Open Targets	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TNRC18	Unknown	28485815	Open Targets	—
		TP53	Unknown	27566247 28481359 22653804	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TPR	Unknown	28485815	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer +27 more
		TRIM27	Unknown	28485815	Open Targets	SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis

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Endometrial mixed adenocarcinoma

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