Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
duodenal adenocarcinoma	MONDO_0006186	GAS7	Unknown	36991000 26804919	Open Targets	—
		GATA1	Unknown	36991000 28481359	Open Targets	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GATA2	Unknown	36991000 28481359	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GATA3	Unknown	36991000	Open Targets	Th1 and Th2 cell differentiation Th17 cell differentiation Parathyroid hormone synthesis, secretion and action +6 more
		GLI1	Unknown	36991000 28481359 26804919	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Pathways in cancer +5 more
		GMPS	Unknown	36991000	Open Targets	Purine metabolism Drug metabolism - other enzymes Metabolic pathways +2 more
		GNA11	Unknown	26998897 36991000	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Hormone signaling +23 more
		GNAS	Unknown	27984236 25867268 36991000 26315110 26998897 24797764	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		GOLGA5	Unknown	36991000	Open Targets	Intra-Golgi traffic
		GOLPH3	Unknown	36991000	Open Targets	—
		GPC3	Unknown	36991000	Open Targets	Proteoglycans in cancer A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis +9 more
		GPC5	Unknown	36991000	Open Targets	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation +7 more
		GPHN	Unknown	36991000 26804919	Open Targets	Folate biosynthesis Metabolic pathways Biosynthesis of cofactors +2 more
		GRIN2A	Unknown	36991000	Open Targets	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		GRM3	Unknown	36991000	Open Targets	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		GSK3B	Unknown	36991000	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Chemokine signaling pathway +59 more
		GTF2I	Unknown	36991000	Open Targets	Basal transcription factors cGMP-PKG signaling pathway
		HERPUD1	Unknown	36991000	Open Targets	Protein processing in endoplasmic reticulum ATF4 activates genes in response to endoplasmic reticulum stress
		HEY1	Unknown	36991000	Open Targets	Notch signaling pathway Human papillomavirus infection Pathways in cancer +4 more
		HGF	Unknown	36991000 26804919	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HIP1	Unknown	36991000 26804919	Open Targets	Huntington disease Pathways of neurodegeneration - multiple diseases Clathrin-mediated endocytosis
		HLA-A	Unknown	36991000 28481359	Open Targets	Endocytosis Phagosome Cellular senescence +25 more
		HLF	Unknown	36991000	Open Targets	—
		HMGA1	Unknown	36991000	Open Targets	Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA +4 more
		HMGA2	Unknown	36991000	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Formation of Senescence-Associated Heterochromatin Foci (SAHF)
		HNF1A	Unknown	36991000 28481359 26804919	Open Targets	Maturity onset diabetes of the young
		HNRNPA2B1	Unknown	36991000	Open Targets	Amyotrophic lateral sclerosis mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA +1 more
		HOOK3	Unknown	36991000 26804919	Open Targets	Motor proteins
		HOXA11	Unknown	36991000	Open Targets	Transcriptional misregulation in cancer
		HOXA9	Unknown	36991000 26804919	Open Targets	Transcriptional misregulation in cancer
		HOXC13	Unknown	36991000	Open Targets	—
		HOXD11	Unknown	36991000	Open Targets	—
		HOXD13	Unknown	36991000	Open Targets	—
		HRAS	Unknown	36991000	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		HSP90AA1	Unknown	36991000	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +56 more
		HSP90AB1	Unknown	36991000 26804919	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +26 more
		IDH1	Unknown	36991000	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IDH2	Unknown	36991000 26804919	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IGF2BP2	Unknown	36991000 26804919	Open Targets	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
		IKBKB	Unknown	36991000 26804919	Open Targets	Antifolate resistance MAPK signaling pathway Ras signaling pathway +79 more
		IKZF1	Unknown	36991000 26804919	Open Targets	—
		IKZF3	Unknown	36991000	Open Targets	—
		IL21R	Unknown	36991000	Open Targets	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +2 more
		IL6ST	Unknown	36991000	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Signaling pathways regulating pluripotency of stem cells +12 more
		IRF4	Unknown	36991000	Open Targets	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		IRS4	Unknown	26998897 36991000 26804919	Open Targets	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling +11 more
		ISX	Unknown	26804919	Open Targets	—
		ITGAV	Unknown	36991000 26804919	Open Targets	Hormone signaling Phagosome Efferocytosis +26 more
		ITK	Unknown	36991000 26804919	Open Targets	Chemokine signaling pathway T cell receptor signaling pathway Leukocyte transendothelial migration +2 more
		JAK1	Unknown	36991000 26804919	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more

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Duodenal adenocarcinoma

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