Diffuse cutaneous systemic sclerosis

Endocytosis Focal adhesion Prion disease Bacterial invasion of epithelial cells Proteoglycans in cancer Viral myocarditis Fluid shear stress and atherosclerosis eNOS activation NOSTRIN mediated eNOS trafficking Basigin interactions Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling FOXO-mediated transcription of cell cycle genes +11 more

Apelin signaling pathway Hippo signaling pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription +1 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events +3 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Toll-like receptor signaling pathway Interferon gamma signaling Interferon alpha/beta signaling

B cell receptor signaling pathway

Endocytosis Focal adhesion Prion disease Bacterial invasion of epithelial cells Proteoglycans in cancer Viral myocarditis Fluid shear stress and atherosclerosis eNOS activation NOSTRIN mediated eNOS trafficking Basigin interactions Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling FOXO-mediated transcription of cell cycle genes +11 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events +3 more

RNA degradation mRNA decay by 5' to 3' exoribonuclease

Phagosome Osteoclast differentiation Platelet activation Neutrophil extracellular trap formation Fc gamma R-mediated phagocytosis Pathogenic Escherichia coli infection Yersinia infection Leishmaniasis Staphylococcus aureus infection Tuberculosis Coronavirus disease - COVID-19 Systemic lupus erythematosus FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis +14 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Cytokine-cytokine receptor interaction JAK-STAT signaling pathway IL-17 signaling pathway Th1 and Th2 cell differentiation Fc epsilon RI signaling pathway Pathways in cancer Asthma Inflammatory bowel disease Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling +7 more

MAPK signaling pathway NF-kappa B signaling pathway Toll-like receptor signaling pathway Neurotrophin signaling pathway Alcoholic liver disease Pathogenic Escherichia coli infection Salmonella infection Pertussis Yersinia infection Leishmaniasis Chagas disease Toxoplasmosis Tuberculosis Hepatitis B Measles Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Lipid and atherosclerosis PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway p75NTR recruits signalling complexes NF-kB is activated and signals survival TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling IRAK1 recruits IKK complex TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane +33 more

Toll-like receptor signaling pathway Interferon gamma signaling Interferon alpha/beta signaling

Necroptosis JAK-STAT signaling pathway Th1 and Th2 cell differentiation Hepatitis B Pathways in cancer Inflammatory bowel disease Interleukin-20 family signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Interleukin-35 Signalling Interleukin-12 signaling Interleukin-23 signaling Interleukin-21 signaling +9 more

ABC transporters Phagosome Antigen processing and presentation Human cytomegalovirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Primary immunodeficiency ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC +7 more

ABC transporters Phagosome Antigen processing and presentation Human cytomegalovirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Primary immunodeficiency ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC +7 more

MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway Endocytosis Cellular senescence TGF-beta signaling pathway Apelin signaling pathway Osteoclast differentiation Hippo signaling pathway Adherens junction Th17 cell differentiation Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Chagas disease Hepatitis B Human T-cell leukemia virus 1 infection Pathways in cancer Colorectal cancer Pancreatic cancer Chronic myeloid leukemia Hepatocellular carcinoma Gastric cancer Diabetic cardiomyopathy Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Ub-specific processing proteases +28 more

Phagosome PI3K-Akt signaling pathway Neutrophil extracellular trap formation Toll-like receptor signaling pathway Salmonella infection Legionellosis Leishmaniasis Chagas disease Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis B Measles Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Proteoglycans in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Rheumatoid arthritis Lipid and atherosclerosis ER-Phagosome pathway Beta defensins MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Modulation by Mtb of host immune system +30 more

Nucleocytoplasmic transport Viral life cycle - HIV-1

Human T-cell leukemia virus 1 infection Viral carcinogenesis Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane +2 more

Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint +9 more

Generic Transcription Pathway