Dejerine-sottas disease

Aminoacyl-tRNA biosynthesis Cytosolic tRNA aminoacylation

Apoptosis Necroptosis

Oxidative phosphorylation Metabolic pathways Cardiac muscle contraction Thermogenesis Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy TP53 Regulates Metabolic Genes Respiratory electron transport +12 more

Lysine degradation Tryptophan metabolism Lipoic acid metabolism Metabolic pathways 2-Oxocarboxylic acid metabolism Glyoxylate metabolism and glycine degradation +3 more

Phagosome Motor proteins Vasopressin-regulated water reabsorption Salmonella infection Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy EML4 and NUDC in mitotic spindle formation +21 more

NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Inositol phosphate metabolism Metabolic pathways Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane +4 more

Aminoacyl-tRNA biosynthesis Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation

Class I peroxisomal membrane protein import

Ras signaling pathway Chemokine signaling pathway Hormone signaling PI3K-Akt signaling pathway Apelin signaling pathway Circadian entrainment Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Relaxin signaling pathway Morphine addiction Alcoholism Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Pathways in cancer Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits +43 more

Glycolysis / Gluconeogenesis Fructose and mannose metabolism Galactose metabolism Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism Neomycin, kanamycin and gentamicin biosynthesis Metabolic pathways Carbon metabolism Biosynthesis of nucleotide sugars HIF-1 signaling pathway Insulin signaling pathway Type II diabetes mellitus Carbohydrate digestion and absorption Shigellosis Central carbon metabolism in cancer Defective HK1 causes hexokinase deficiency (HK deficiency) Glycolysis +14 more

MAPK signaling pathway VEGF signaling pathway Amoebiasis VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling +4 more

HSF1-dependent transactivation

Cytoskeleton in muscle cells

Aminoacyl-tRNA biosynthesis Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation

Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins

Antigen processing: Ubiquitination & Proteasome degradation

Selenocompound metabolism Aminoacyl-tRNA biosynthesis Metabolic pathways Cytosolic tRNA aminoacylation +1 more

Mitophagy - animal NOD-like receptor signaling pathway Parkinson disease Pathways of neurodegeneration - multiple diseases Pink/Parkin Mediated Mitophagy Factors involved in megakaryocyte development and platelet production +3 more

Renin-angiotensin system Hematopoietic cell lineage Protein digestion and absorption Alzheimer disease Metabolism of Angiotensinogen to Angiotensins Neutrophil degranulation +3 more

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Unblocking of NMDA receptors, glutamate binding and activation RAF/MAP kinase cascade +1 more

Diabetic cardiomyopathy Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid

Pathways in cancer NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events +1 more

Pentose phosphate pathway Purine metabolism Metabolic pathways Carbon metabolism Biosynthesis of amino acids 5-Phosphoribose 1-diphosphate biosynthesis +3 more

Synthesis of PIPs at the ER membrane RAB GEFs exchange GTP for GDP on RABs

Cation-coupled Chloride cotransporters Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)

TP53 Regulates Metabolic Genes Respiratory electron transport

Interferon gamma signaling

Cellular senescence Inflammatory mediator regulation of TRP channels Fluid shear stress and atherosclerosis TRP channels +1 more

Mitophagy - animal Protein processing in endoplasmic reticulum Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Legionellosis Translesion Synthesis by POLH HSF1 activation ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Hedgehog ligand biogenesis Hh mutants that don't undergo autocatalytic processing are degraded by ERAD Defective CFTR causes cystic fibrosis Josephin domain DUBs Ovarian tumor domain proteases Neutrophil degranulation E3 ubiquitin ligases ubiquitinate target proteins Protein methylation +14 more

C-type lectin receptor signaling pathway Hepatitis B Human T-cell leukemia virus 1 infection Viral carcinogenesis NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination +3 more

Cell adhesion molecules EGR2 and SOX10-mediated initiation of Schwann cell myelination

EGR2 and SOX10-mediated initiation of Schwann cell myelination

EGR2 and SOX10-mediated initiation of Schwann cell myelination