Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
cortisol-producing adrenal cortex adenoma	MONDO_0006174	AFF1	Unknown	27389594	Open Targets	Transcriptional misregulation in cancer
		ALDH2	Unknown	27389594	Open Targets	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +14 more
		APC	Unknown	24700472 27389594	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		ARID1A	Unknown	24700472	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID1B	Unknown	27389594	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ASXL2	Unknown	27389594	Open Targets	Polycomb repressive complex UCH proteinases
		ATRX	Unknown	27389594 25743702	Open Targets	Cell cycle
		BCL3	Unknown	27389594	Open Targets	C-type lectin receptor signaling pathway TNF signaling pathway
		BCL9L	Unknown	24700472	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCR	Unknown	24855271	Open Targets	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
		BIRC6	Unknown	24700472	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		BRAF	Unknown	19498322	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		CASP3	Unknown	27389594	Open Targets	Platinum drug resistance MAPK signaling pathway p53 signaling pathway +53 more
		CDC73	Unknown	27389594	Open Targets	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state +3 more
		CEBPA	Unknown	24571724	Open Targets	Non-alcoholic fatty liver disease Pathways in cancer Transcriptional misregulation in cancer +3 more
		CHD2	Unknown	24700472	Open Targets	—
		CHD4	Unknown	24571724	Open Targets	ATP-dependent chromatin remodeling Human papillomavirus infection Viral carcinogenesis +5 more
		CREB1	Unknown	27389594	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis +53 more
		CREBBP	Unknown	27389594	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		CRNKL1	Unknown	24571724	Open Targets	Spliceosome mRNA Splicing - Major Pathway
		CSMD3	Unknown	24571724	Open Targets	—
		CTNNA1	Unknown	24700472	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +9 more
		CTNNB1	Unknown	25743702 28973495 25750087 24700472 24747643 27389594 27468715 17854394 19498322	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		CUL3	Unknown	27389594	Open Targets	Ubiquitin mediated proteolysis Hedgehog signaling pathway Degradation of DVL +4 more
		CUX1	Unknown	27389594	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic
		DROSHA	Unknown	24700472	Open Targets	Ribosome biogenesis in eukaryotes Proteoglycans in cancer MicroRNA (miRNA) biogenesis
		ELK4	Unknown	27389594	Open Targets	MAPK signaling pathway Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer
		ERG	Unknown	27389594	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		FAT3	Unknown	25743702	Open Targets	—
		FAT4	Unknown	24700472 25743702 27389594	Open Targets	Hippo signaling pathway - multiple species
		GNAS	Unknown	22259056 27606678 25750087 24700472 24855271 24747643 26743443 27389594	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		GRM3	Unknown	27389594	Open Targets	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		KDM6A	Unknown	24700472	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KMT2D	Unknown	24571724	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		LRP1B	Unknown	25743702	Open Targets	—
		MAP2K2	Unknown	27389594	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +87 more
		MECOM	Unknown	27389594	Open Targets	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
		MED12	Unknown	27389594 25743702	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MITF	Unknown	27389594	Open Targets	Mitophagy - animal Osteoclast differentiation Melanogenesis +4 more
		MYH9	Unknown	27389594	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +8 more
		NRG1	Unknown	24700472	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis +18 more
		NUMA1	Unknown	24855271	Open Targets	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
		PBX1	Unknown	24571724	Open Targets	Efferocytosis Cortisol synthesis and secretion Cushing syndrome +3 more
		PRKACA	Unknown	25069672 27606678 24571724 25750087 24700472 24855271 25057884 24747643 27296931 27389594	Open Targets	Endocrine resistance MAPK signaling pathway Ras signaling pathway +95 more
		PRKAR1A	Unknown	24700472 27389594	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		QKI	Unknown	24700472	Open Targets	Signaling by BRAF and RAF fusions
		RB1	Unknown	24747643	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RBM10	Unknown	27389594	Open Targets	—
		RICTOR	Unknown	27389594	Open Targets	mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling +3 more
		RMI2	Unknown	24700472	Open Targets	Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +7 more

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Cortisol-producing adrenal cortex adenoma

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