Connective tissue disease

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

Cytokine-cytokine receptor interaction TGF-beta signaling pathway Axon guidance Hippo signaling pathway Molecules associated with elastic fibres +2 more

Cell adhesion molecules Adherens junctions interactions Myogenesis

ABC transporters cAMP signaling pathway AMPK signaling pathway Tight junction Gastric acid secretion Pancreatic secretion Bile secretion Vibrio cholerae infection ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Aggrephagy +12 more

Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB

A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Release of Hh-Np from the secreting cell Retinoid metabolism and transport +7 more

Basal transcription factors cGMP-PKG signaling pathway

Apelin signaling pathway Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis MicroRNAs in cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins RUNX3 regulates p14-ARF +8 more

Maturity onset diabetes of the young Transcriptional misregulation in cancer

Endocytosis Phagosome Cellular senescence Cell adhesion molecules Antigen processing and presentation Natural killer cell mediated cytotoxicity Type I diabetes mellitus Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Viral carcinogenesis Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Viral myocarditis ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC +24 more

cGMP-PKG signaling pathway Vascular smooth muscle contraction Insulin secretion Ca2+ activated K+ channels +1 more

Rap1 signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction PI3K-Akt signaling pathway Pathways in cancer G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors +5 more

Calcium signaling pathway cGMP-PKG signaling pathway Vascular smooth muscle contraction Apelin signaling pathway Focal adhesion Platelet activation Regulation of actin cytoskeleton Oxytocin signaling pathway Gastric acid secretion Smooth Muscle Contraction RHO GTPases activate PAKs +8 more

mRNA surveillance pathway mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs +2 more

Insulin secretion

Glycolysis / Gluconeogenesis Pentose phosphate pathway Fructose and mannose metabolism Galactose metabolism Metabolic pathways Carbon metabolism Biosynthesis of amino acids RNA degradation HIF-1 signaling pathway AMPK signaling pathway Thyroid hormone signaling pathway Glucagon signaling pathway Central carbon metabolism in cancer Glycolysis +11 more

Arachidonic acid metabolism Metabolic pathways Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Nicotinamide salvaging Eicosanoids Sterols are 12-hydroxylated by CYP8B1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) +6 more

Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules

Type I diabetes mellitus Neutrophil degranulation

Synaptic vesicle cycle Retrograde endocannabinoid signaling Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation +5 more

Viral life cycle - HIV-1 Serine biosynthesis

Bicarbonate transporters

Hedgehog signaling pathway Hedgehog 'on' state

Adherens junction

Cytoskeleton in muscle cells

Metabolism of vitamin K

Homologous recombination Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint +3 more

Hedgehog 'off' state Intraflagellar transport

Cell cycle Oocyte meiosis PI3K-Akt signaling pathway Hippo signaling pathway NOD-like receptor signaling pathway Neurotrophin signaling pathway Hepatitis C Viral carcinogenesis Activation of BAD and translocation to mitochondria Signaling by Hippo NADE modulates death signalling Regulation of PLK1 Activity at G2/M Transition Regulation of HSF1-mediated heat shock response HSF1 activation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RAB GEFs exchange GTP for GDP on RABs +22 more

ErbB signaling pathway Ras signaling pathway Cell cycle Axon guidance Neurotrophin signaling pathway Pathogenic Escherichia coli infection Pathways in cancer MicroRNAs in cancer Chemical carcinogenesis - reactive oxygen species Chronic myeloid leukemia Viral myocarditis Regulation of actin dynamics for phagocytic cup formation Role of ABL in ROBO-SLIT signaling Myogenesis RHO GTPases Activate WASPs and WAVEs HDR through Single Strand Annealing (SSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Cyclin D associated events in G1 RUNX1 regulates transcription of genes involved in differentiation of HSCs FCGR3A-mediated phagocytosis +17 more

Vascular smooth muscle contraction Apelin signaling pathway Motor proteins Relaxin signaling pathway Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription +3 more

Thiamine metabolism Folate biosynthesis Metabolic pathways Biosynthesis of cofactors Post-translational modification: synthesis of GPI-anchored proteins +2 more

Glycosphingolipid metabolism The activation of arylsulfatases

Glycine, serine and threonine metabolism Cysteine and methionine metabolism One carbon pool by folate Metabolic pathways Biosynthesis of amino acids Cysteine formation from homocysteine +3 more

Cytoskeleton in muscle cells Protein digestion and absorption Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Non-integrin membrane-ECM interactions MET activates PTK2 signaling Collagen chain trimerization +5 more

Cytoskeleton in muscle cells Protein digestion and absorption Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Non-integrin membrane-ECM interactions MET activates PTK2 signaling Collagen chain trimerization +5 more

Calcium signaling pathway cGMP-PKG signaling pathway Vascular smooth muscle contraction Apelin signaling pathway Focal adhesion Platelet activation Regulation of actin cytoskeleton Oxytocin signaling pathway Gastric acid secretion Smooth Muscle Contraction RHO GTPases activate PAKs +8 more

Hedgehog 'off' state Intraflagellar transport

Vascular smooth muscle contraction Apelin signaling pathway Motor proteins Relaxin signaling pathway Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription +3 more

ErbB signaling pathway Ras signaling pathway Cell cycle Axon guidance Neurotrophin signaling pathway Pathogenic Escherichia coli infection Pathways in cancer MicroRNAs in cancer Chemical carcinogenesis - reactive oxygen species Chronic myeloid leukemia Viral myocarditis Regulation of actin dynamics for phagocytic cup formation Role of ABL in ROBO-SLIT signaling Myogenesis RHO GTPases Activate WASPs and WAVEs HDR through Single Strand Annealing (SSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Cyclin D associated events in G1 RUNX1 regulates transcription of genes involved in differentiation of HSCs FCGR3A-mediated phagocytosis +17 more

Calcium signaling pathway cGMP-PKG signaling pathway Vascular smooth muscle contraction Apelin signaling pathway Focal adhesion Platelet activation Regulation of actin cytoskeleton Oxytocin signaling pathway Gastric acid secretion Smooth Muscle Contraction RHO GTPases activate PAKs +8 more