Congestive heart failure

Fatty acid elongation Biosynthesis of unsaturated fatty acids Metabolic pathways Fatty acid metabolism Activation of gene expression by SREBF (SREBP) Synthesis of very long-chain fatty acyl-CoAs +3 more

Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway HIF-1 signaling pathway FoxO signaling pathway Cell cycle Wnt signaling pathway Notch signaling pathway TGF-beta signaling pathway Adherens junction JAK-STAT signaling pathway Long-term potentiation Melanogenesis Thyroid hormone signaling pathway Glucagon signaling pathway Growth hormone synthesis, secretion and action Huntington disease Tuberculosis Hepatitis B Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Viral carcinogenesis MicroRNAs in cancer Renal cell carcinoma Prostate cancer Regulation of gene expression by Hypoxia-inducible Factor RORA activates gene expression Polo-like kinase mediated events Pre-NOTCH Transcription and Translation PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production HATs acetylate histones Attenuation phase Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Circadian Clock B-WICH complex positively regulates rRNA expression CD209 (DC-SIGN) signaling Metalloprotease DUBs Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NGF-stimulated transcription TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Transcriptional regulation of granulopoiesis Regulation of FOXO transcriptional activity by acetylation +66 more

Arachidonic acid metabolism Metabolic pathways Peroxisome Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Biosynthesis of maresins Peroxisomal protein import +5 more

Cytokine-cytokine receptor interaction HIF-1 signaling pathway Hormone signaling Efferocytosis PI3K-Akt signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage Pathways in cancer Regulation of gene expression by Hypoxia-inducible Factor Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates RAS +8 more

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Lysine degradation Metabolic pathways Polycomb repressive complex MicroRNAs in cancer PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events +7 more

Fatty acid biosynthesis Metabolic pathways Fatty acid metabolism AMPK signaling pathway Insulin signaling pathway Alcoholic liver disease ChREBP activates metabolic gene expression Vitamin B5 (pantothenate) metabolism Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis +8 more

Elastic fibre formation Molecules associated with elastic fibres

mRNA surveillance pathway Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs Signaling by cytosolic PDGFRA and PDGFRB fusion proteins +4 more

Reversal of alkylation damage by DNA dioxygenases

Glycine, serine and threonine metabolism Arginine and proline metabolism Metabolic pathways Creatine metabolism +1 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Thermogenesis Insulin secretion Glucagon signaling pathway Glucagon signaling in metabolic regulation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events G alpha (s) signalling events Glucagon-type ligand receptors Synthesis, secretion, and deacylation of Ghrelin ADORA2B mediated anti-inflammatory cytokines production +11 more

Cytokine-cytokine receptor interaction

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Growth hormone synthesis, secretion and action G alpha (q) signalling events Synthesis, secretion, and deacylation of Ghrelin +3 more

Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway Chemokine signaling pathway Sphingolipid signaling pathway Hormone signaling Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Apelin signaling pathway Gap junction Platelet activation Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse Dopaminergic synapse Long-term depression Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Oxytocin signaling pathway Glucagon signaling pathway Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action GnRH secretion Cushing syndrome Growth hormone synthesis, secretion and action Endocrine and other factor-regulated calcium reabsorption Salivary secretion Gastric acid secretion Pancreatic secretion Alzheimer disease Huntington disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Yersinia infection Chagas disease African trypanosomiasis Amoebiasis Human cytomegalovirus infection Human immunodeficiency virus 1 infection Pathways in cancer Acetylcholine regulates insulin secretion G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) +52 more

Ras signaling pathway Chemokine signaling pathway Hormone signaling PI3K-Akt signaling pathway Apelin signaling pathway Circadian entrainment Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Olfactory transduction Phototransduction Relaxin signaling pathway Morphine addiction Alcoholism Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Pathways in cancer Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Activation of the phototransduction cascade Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Olfactory Signaling Pathway ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits +47 more

Glutathione metabolism Arachidonic acid metabolism Metabolic pathways Ferroptosis Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Biosynthesis of D-series resolvins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins +7 more

Chemokine signaling pathway Endocytosis Hedgehog signaling pathway Glutamatergic synapse Olfactory transduction Morphine addiction Calmodulin induced events G alpha (q) signalling events G alpha (s) signalling events Activation of SMO Cargo recognition for clathrin-mediated endocytosis +8 more

EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Chemokine signaling pathway Cell cycle mTOR signaling pathway PI3K-Akt signaling pathway Wnt signaling pathway Hedgehog signaling pathway Axon guidance Hippo signaling pathway Focal adhesion Signaling pathways regulating pluripotency of stem cells IL-17 signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway Neurotrophin signaling pathway Dopaminergic synapse Insulin signaling pathway Melanogenesis Prolactin signaling pathway Thyroid hormone signaling pathway Insulin resistance Non-alcoholic fatty liver disease Cushing syndrome Growth hormone synthesis, secretion and action Alcoholic liver disease Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Shigellosis Yersinia infection Hepatitis C Measles Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Colorectal cancer Endometrial cancer Prostate cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer Diabetic cardiomyopathy Lipid and atherosclerosis Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Regulation of HSF1-mediated heat shock response CRMPs in Sema3A signaling Disassembly of the destruction complex and recruitment of AXIN to the membrane B-WICH complex positively regulates rRNA expression Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex GLI3 is processed to GLI3R by the proteasome Constitutive Signaling by AKT1 E17K in Cancer +59 more

HIF-1 signaling pathway Mitophagy - animal Autophagy - animal Efferocytosis Th17 cell differentiation Thyroid hormone signaling pathway Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - reactive oxygen species Renal cell carcinoma Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Regulation of gene expression by Hypoxia-inducible Factor Cellular response to hypoxia Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling PTK6 Expression PTK6 promotes HIF1A stabilization Neddylation +19 more

Valine, leucine and isoleucine degradation Butanoate metabolism Terpenoid backbone biosynthesis Metabolic pathways PPAR signaling pathway PPARA activates gene expression Synthesis of Ketone Bodies +4 more

Porphyrin metabolism Metabolic pathways HIF-1 signaling pathway Ferroptosis Mineral absorption Pathways in cancer MicroRNAs in cancer Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis Heme degradation Interleukin-4 and Interleukin-13 signaling Iron uptake and transport Insertion of tail-anchored proteins into the endoplasmic reticulum membrane +11 more

MAPK signaling pathway VEGF signaling pathway Amoebiasis VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling +4 more

Calcium signaling pathway Neuroactive ligand-receptor interaction Gap junction Serotonergic synapse Inflammatory mediator regulation of TRP channels Serotonin receptors G alpha (q) signalling events +4 more

Interferon alpha/beta signaling

Proteasome Cytokine-cytokine receptor interaction HIF-1 signaling pathway Necroptosis TGF-beta signaling pathway Osteoclast differentiation Antigen processing and presentation JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway Type I diabetes mellitus Leishmaniasis Chagas disease African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis C Influenza A Herpes simplex virus 1 infection Pathways in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Fluid shear stress and atherosclerosis Interferon gamma signaling Regulation of IFNG signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation +33 more

Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction NF-kappa B signaling pathway Necroptosis Osteoclast differentiation Toll-like receptor signaling pathway NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Th17 cell differentiation TNF signaling pathway Inflammatory mediator regulation of TRP channels Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Type I diabetes mellitus Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Leishmaniasis Chagas disease African trypanosomiasis Malaria Amoebiasis Tuberculosis Measles Human cytomegalovirus infection Influenza A Herpes simplex virus 1 infection Coronavirus disease - COVID-19 Inflammatory bowel disease Rheumatoid arthritis Graft-versus-host disease Lipid and atherosclerosis Fluid shear stress and atherosclerosis Interleukin-1 processing CLEC7A/inflammasome pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection +47 more

EGFR tyrosine kinase inhibitor resistance Antifolate resistance Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor HIF-1 signaling pathway FoxO signaling pathway PI3K-Akt signaling pathway Cellular senescence Toll-like receptor signaling pathway NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Th17 cell differentiation TNF signaling pathway Intestinal immune network for IgA production Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Pertussis Legionellosis Yersinia infection Chagas disease African trypanosomiasis Malaria Amoebiasis Tuberculosis Hepatitis B Measles Human cytomegalovirus infection Influenza A Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Coronavirus disease - COVID-19 Pathways in cancer Transcriptional misregulation in cancer Inflammatory bowel disease Rheumatoid arthritis Graft-versus-host disease Hypertrophic cardiomyopathy Lipid and atherosclerosis Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response +59 more

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway HIF-1 signaling pathway FoxO signaling pathway Phospholipase D signaling pathway Hormone signaling Oocyte meiosis Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Regulation of actin cytoskeleton Insulin signaling pathway Insulin secretion Ovarian steroidogenesis Progesterone-mediated oocyte maturation Prolactin signaling pathway Regulation of lipolysis in adipocytes Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease Type I diabetes mellitus Maturity onset diabetes of the young Aldosterone-regulated sodium reabsorption Alzheimer disease Prostate cancer Diabetic cardiomyopathy Insulin processing Synthesis, secretion, and deacylation of Ghrelin COPI-mediated anterograde transport PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Amyloid fiber formation +39 more

Virion - Rotavirus Rap1 signaling pathway Phagosome PI3K-Akt signaling pathway Axon guidance Focal adhesion ECM-receptor interaction Cell adhesion molecules Tight junction Platelet activation Leukocyte transendothelial migration Regulation of actin cytoskeleton Cytoskeleton in muscle cells Bacterial invasion of epithelial cells Pathogenic Escherichia coli infection Shigellosis Pertussis Yersinia infection Leishmaniasis Toxoplasmosis Human papillomavirus infection Pathways in cancer Proteoglycans in cancer Small cell lung cancer Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Elastic fibre formation Fibronectin matrix formation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Basigin interactions Molecules associated with elastic fibres Integrin cell surface interactions Laminin interactions Syndecan interactions ECM proteoglycans Signal transduction by L1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling MET activates PTK2 signaling MET interacts with TNS proteins HCMV Early Events +41 more

HATs acetylate histones

Cholesterol metabolism

EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway HIF-1 signaling pathway FoxO signaling pathway Sphingolipid signaling pathway Phospholipase D signaling pathway Oocyte meiosis Autophagy - animal Efferocytosis mTOR signaling pathway PI3K-Akt signaling pathway Apoptosis Cellular senescence Vascular smooth muscle contraction VEGF signaling pathway Apelin signaling pathway Osteoclast differentiation Focal adhesion Gap junction Signaling pathways regulating pluripotency of stem cells Neutrophil extracellular trap formation Toll-like receptor signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis TNF signaling pathway Long-term potentiation Neurotrophin signaling pathway Cholinergic synapse Serotonergic synapse Long-term depression Regulation of actin cytoskeleton Insulin signaling pathway GnRH signaling pathway Progesterone-mediated oocyte maturation Estrogen signaling pathway Melanogenesis Prolactin signaling pathway Thyroid hormone signaling pathway Oxytocin signaling pathway Relaxin signaling pathway Parathyroid hormone synthesis, secretion and action GnRH secretion Cushing syndrome Growth hormone synthesis, secretion and action Alzheimer disease Pathways of neurodegeneration - multiple diseases Alcoholism Salmonella infection Yersinia infection Hepatitis C Hepatitis B Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Melanoma Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer MAPK3 (ERK1) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants +99 more

MAPK signaling pathway ErbB signaling pathway Protein processing in endoplasmic reticulum Osteoclast differentiation Tight junction Toll-like receptor signaling pathway T cell receptor signaling pathway Fc epsilon RI signaling pathway TNF signaling pathway Neurotrophin signaling pathway GnRH signaling pathway Relaxin signaling pathway Alcoholic liver disease Alzheimer disease Huntington disease Pathways of neurodegeneration - multiple diseases Salmonella infection Yersinia infection Hepatitis B Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Chemical carcinogenesis - reactive oxygen species Lipid and atherosclerosis Fluid shear stress and atherosclerosis Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins +26 more

Endocrine resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway cAMP signaling pathway FoxO signaling pathway Sphingolipid signaling pathway Mitophagy - animal Autophagy - animal Protein processing in endoplasmic reticulum Apoptosis Apoptosis - multiple species Necroptosis Wnt signaling pathway Osteoclast differentiation Focal adhesion Tight junction Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway C-type lectin receptor signaling pathway IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway Fc epsilon RI signaling pathway TNF signaling pathway Neurotrophin signaling pathway Retrograde endocannabinoid signaling Dopaminergic synapse Inflammatory mediator regulation of TRP channels Insulin signaling pathway GnRH signaling pathway Progesterone-mediated oocyte maturation Prolactin signaling pathway Adipocytokine signaling pathway Relaxin signaling pathway Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Alcoholic liver disease Alzheimer disease Parkinson disease Huntington disease Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Yersinia infection Chagas disease Toxoplasmosis Tuberculosis Hepatitis B Measles Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Chemical carcinogenesis - reactive oxygen species Colorectal cancer Pancreatic cancer Choline metabolism in cancer Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors +74 more

PPAR signaling pathway IL-17 signaling pathway Relaxin signaling pathway Coronavirus disease - COVID-19 Pathways in cancer Bladder cancer Rheumatoid arthritis Lipid and atherosclerosis Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Basigin interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling +11 more

Cytokine-cytokine receptor interaction

One carbon pool by folate Metabolic pathways Biosynthesis of cofactors Metabolism of folate and pterines +1 more

Viral life cycle - HIV-1 Hepatitis C Measles Influenza A Human papillomavirus infection Coronavirus disease - COVID-19 ISG15 antiviral mechanism Interferon alpha/beta signaling +5 more

cGMP-PKG signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins Cytoskeleton in muscle cells Thyroid hormone signaling pathway Hypertrophic cardiomyopathy Dilated cardiomyopathy Viral myocarditis Striated Muscle Contraction +7 more

Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Lipid and atherosclerosis Fluid shear stress and atherosclerosis +4 more

Arginine biosynthesis Arginine and proline metabolism Metabolic pathways Calcium signaling pathway HIF-1 signaling pathway Peroxisome Apelin signaling pathway Relaxin signaling pathway Alzheimer disease Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Pertussis Leishmaniasis Chagas disease Toxoplasmosis Amoebiasis Tuberculosis Pathways in cancer Small cell lung cancer ROS and RNS production in phagocytes Nitric oxide stimulates guanylate cyclase Interleukin-4 and Interleukin-13 signaling Peroxisomal protein import Inhibition of nitric oxide production +21 more

Arginine biosynthesis Arginine and proline metabolism Metabolic pathways Calcium signaling pathway cGMP-PKG signaling pathway HIF-1 signaling pathway Sphingolipid signaling pathway PI3K-Akt signaling pathway VEGF signaling pathway Apelin signaling pathway Platelet activation Estrogen signaling pathway Oxytocin signaling pathway Relaxin signaling pathway Insulin resistance AGE-RAGE signaling pathway in diabetic complications Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis ROS and RNS production in phagocytes Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation eNOS activation NOSTRIN mediated eNOS trafficking NOSIP mediated eNOS trafficking Nitric oxide stimulates guanylate cyclase VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling +24 more

Osteoclast differentiation AGE-RAGE signaling pathway in diabetic complications Alzheimer disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Lipid and atherosclerosis Fluid shear stress and atherosclerosis RHO GTPases Activate NADPH Oxidases WNT5:FZD7-mediated leishmania damping +6 more