Congestive heart failure

ABC transporters Insulin secretion Type II diabetes mellitus ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypoglycemias and hyperglycemias +3 more

Antifolate resistance ABC transporters Bile secretion Folate transport and metabolism Heme biosynthesis Heme degradation Iron uptake and transport +4 more

Fatty acid biosynthesis Pyruvate metabolism Propanoate metabolism Metabolic pathways Fatty acid metabolism AMPK signaling pathway Insulin signaling pathway Glucagon signaling pathway Alcoholic liver disease ChREBP activates metabolic gene expression Biotin transport and metabolism Carnitine metabolism Activation of gene expression by SREBF (SREBP) Defective HLCS causes multiple carboxylase deficiency Fatty acyl-CoA biosynthesis +12 more

Fatty acid degradation Valine, leucine and isoleucine degradation beta-Alanine metabolism Propanoate metabolism Butanoate metabolism Metabolic pathways Carbon metabolism Fatty acid metabolism Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA +7 more

Renin-angiotensin system Renin secretion Chagas disease Coronavirus disease - COVID-19 Hypertrophic cardiomyopathy Diabetic cardiomyopathy Metabolism of Angiotensinogen to Angiotensins +4 more

Renin-angiotensin system Protein digestion and absorption Coronavirus disease - COVID-19 Metabolism of Angiotensinogen to Angiotensins +1 more

Citrate cycle (TCA cycle) Metabolic pathways ChREBP activates metabolic gene expression Neutrophil degranulation Fatty acyl-CoA biosynthesis +2 more

PPAR signaling pathway Hormone signaling AMPK signaling pathway Longevity regulating pathway Adipocytokine signaling pathway Type II diabetes mellitus Non-alcoholic fatty liver disease Alcoholic liver disease AMPK inhibits chREBP transcriptional activation activity Transcriptional regulation of white adipocyte differentiation +7 more

cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events G alpha (z) signalling events Surfactant metabolism +6 more

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Adrenergic signaling in cardiomyocytes Gap junction Regulation of lipolysis in adipocytes Renin secretion Salivary secretion Chemical carcinogenesis - receptor activation Dilated cardiomyopathy Adrenoceptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +12 more

Calcium signaling pathway cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Thermogenesis Regulation of lipolysis in adipocytes Renin secretion Salivary secretion Chemical carcinogenesis - receptor activation Adrenoceptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +9 more

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Renin-angiotensin system Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion Insulin resistance AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Pathways in cancer Hypertrophic cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy PPARA activates gene expression Metabolism of Angiotensinogen to Angiotensins Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events +18 more

Calcium signaling pathway cGMP-PKG signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Apelin signaling pathway Renin-angiotensin system Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Coronavirus disease - COVID-19 Pathways in cancer Diabetic cardiomyopathy Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis +18 more

Alanine, aspartate and glutamate metabolism Glycine, serine and threonine metabolism Cysteine and methionine metabolism Valine, leucine and isoleucine degradation Metabolic pathways 2-Oxocarboxylic acid metabolism Glyoxylate metabolism and glycine degradation +4 more

Thyroid hormone synthesis Platelet degranulation Recycling of bile acids and salts Heme biosynthesis Heme degradation Scavenging of heme from plasma Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transport of organic anions Post-translational protein phosphorylation HDL remodeling +7 more

Purine metabolism Metabolic pathways Nucleotide metabolism Cytoskeleton in muscle cells Purine salvage +2 more

Amyloid fiber formation

Cholesterol metabolism VLDL assembly VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux +1 more

Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport +10 more

Arginine biosynthesis Arginine and proline metabolism Metabolic pathways Biosynthesis of amino acids Efferocytosis Amoebiasis Urea cycle +4 more

cGMP-PKG signaling pathway cAMP signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Cytoskeleton in muscle cells Insulin secretion Thyroid hormone synthesis Thyroid hormone signaling pathway Aldosterone synthesis and secretion Aldosterone-regulated sodium reabsorption Endocrine and other factor-regulated calcium reabsorption Proximal tubule bicarbonate reclamation Salivary secretion Gastric acid secretion Pancreatic secretion Carbohydrate digestion and absorption Protein digestion and absorption Bile secretion Mineral absorption Ion homeostasis Ion transport by P-type ATPases +18 more

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Osteoclast differentiation Thyroid hormone signaling pathway Pancreatic secretion Alzheimer disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases +16 more

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Osteoclast differentiation Thyroid hormone signaling pathway Pancreatic secretion Alzheimer disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases +16 more

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Vascular smooth muscle contraction Vasopressin-regulated water reabsorption Vasopressin-like receptors G alpha (q) signalling events G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) Transport of organic anions Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ADORA2B mediated anti-inflammatory cytokines production +12 more

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Vasopressin-regulated water reabsorption Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ADORA2B mediated anti-inflammatory cytokines production +8 more

Wnt signaling pathway TGF-beta signaling pathway Downregulation of TGF-beta receptor signaling

BBSome-mediated cargo-targeting to cilium

Tryptophan metabolism Glyoxylate and dicarboxylate metabolism Metabolic pathways Carbon metabolism FoxO signaling pathway Peroxisome Longevity regulating pathway Longevity regulating pathway - multiple species Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Detoxification of Reactive Oxygen Species Neutrophil degranulation Peroxisomal protein import +11 more

ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis Insulin signaling pathway Bacterial invasion of epithelial cells Pathways in cancer Proteoglycans in cancer Chronic myeloid leukemia Interleukin-6 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Spry regulation of FGF signaling Regulation of KIT signaling EGFR downregulation TGF-beta receptor signaling activates SMADs Constitutive Signaling by EGFRvIII Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Negative regulation of MET activity PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Regulation of signaling by CBL +22 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway NOD-like receptor signaling pathway IL-17 signaling pathway TNF signaling pathway AGE-RAGE signaling pathway in diabetic complications Yersinia infection Chagas disease Malaria Human cytomegalovirus infection Influenza A Herpes simplex virus 1 infection Coronavirus disease - COVID-19 Rheumatoid arthritis Lipid and atherosclerosis Fluid shear stress and atherosclerosis Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling +18 more

Apelin signaling pathway Hippo signaling pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription +1 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling +4 more

Endocrine resistance Platinum drug resistance ErbB signaling pathway HIF-1 signaling pathway FoxO signaling pathway Cell cycle p53 signaling pathway PI3K-Akt signaling pathway Cellular senescence JAK-STAT signaling pathway Oxytocin signaling pathway Parathyroid hormone synthesis, secretion and action Cushing syndrome Hepatitis C Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Basal cell carcinoma Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint TFAP2 (AP-2) family regulates transcription of cell cycle factors Transcriptional regulation by RUNX2 RUNX3 regulates CDKN1A transcription Transcriptional regulation of granulopoiesis FOXO-mediated transcription of cell cycle genes +56 more

Complement and coagulation cascades Staphylococcus aureus infection Coronavirus disease - COVID-19 Platelet degranulation Alternative complement activation Neutrophil degranulation +3 more

Glycine, serine and threonine metabolism One carbon pool by folate Metabolic pathways Choline catabolism +1 more

AMPK signaling pathway Lipid particle organization

Stimuli-sensing channels

Classical antibody-mediated complement activation

Lysine catabolism

Citrate cycle (TCA cycle) Glyoxylate and dicarboxylate metabolism Metabolic pathways Carbon metabolism 2-Oxocarboxylic acid metabolism Biosynthesis of amino acids Citric acid cycle (TCA cycle) +4 more

Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Hematopoietic cell lineage Natural killer cell mediated cytotoxicity IL-17 signaling pathway T cell receptor signaling pathway Fc epsilon RI signaling pathway TNF signaling pathway Shigellosis Amoebiasis Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Coronavirus disease - COVID-19 Transcriptional misregulation in cancer Acute myeloid leukemia Rheumatoid arthritis Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin-10 signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Interleukin receptor SHC signaling +18 more

Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Malaria Coronavirus disease - COVID-19 Other interleukin signaling Interleukin-10 signaling +6 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway NF-kappa B signaling pathway NOD-like receptor signaling pathway IL-17 signaling pathway TNF signaling pathway Alcoholic liver disease Epithelial cell signaling in Helicobacter pylori infection Legionellosis Amoebiasis Kaposi sarcoma-associated herpesvirus infection Rheumatoid arthritis Lipid and atherosclerosis Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling +14 more

HIF-1 signaling pathway Phagosome Ferroptosis Necroptosis Neutrophil extracellular trap formation NOD-like receptor signaling pathway Leukocyte transendothelial migration AGE-RAGE signaling pathway in diabetic complications Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Leishmaniasis Coronavirus disease - COVID-19 Diabetic cardiomyopathy Lipid and atherosclerosis ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation +18 more

cAMP signaling pathway HIF-1 signaling pathway Neuroactive ligand-receptor interaction Vascular smooth muscle contraction TNF signaling pathway Melanogenesis Renin secretion Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer Hypertrophic cardiomyopathy Fluid shear stress and atherosclerosis Peptide ligand-binding receptors G alpha (q) signalling events +11 more

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Vascular smooth muscle contraction Renin secretion Pathways in cancer Peptide ligand-binding receptors G alpha (q) signalling events +6 more

Calcium signaling pathway cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction Melanogenesis Relaxin signaling pathway Pathways in cancer Peptide ligand-binding receptors G alpha (q) signalling events +5 more