Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
COLORECTAL CANCER	MONDO_0005575 114500 MONDO:0005575	AGER	Unknown	32887889	GWAS catalog	Efferocytosis Neutrophil extracellular trap formation AGE-RAGE signaling pathway in diabetic complications +7 more
		AGTPBP1	Unknown	38538606	GWAS catalog	—
		AHR	Unknown	32887889	GWAS catalog	Th17 cell differentiation Cushing syndrome Chemical carcinogenesis - receptor activation +6 more
		AIF1	Unknown	32887889	GWAS catalog	—
		AKAP10	Unknown	38538606	GWAS catalog	Factors involved in megakaryocyte development and platelet production
		AKAP11	Unknown	38411962	GWAS catalog	—
		AKAP6	Unknown	34290314	GWAS catalog	—
		AKR1A1	Unknown	38408508	GWAS catalog	Glycolysis / Gluconeogenesis Pentose and glucuronate interconversions Ascorbate and aldarate metabolism +7 more
		AKT1	Unknown	10598809 18033691 9087566 8872463 12655564 9065402 14504054 10882759 11709755 19218458 9611074 22102614 9989816 24308539 10413423 17000706 21917714 7898930 12792735 9559627 14961575 23263490 10537275 11153917 11807791 12522549 12738854 10699937 14520694	ClinVar, HPO	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		ALDH2	Unknown	38872215	GWAS catalog	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +14 more
		ALDOB	Unknown	29228715	GWAS catalog	Glycolysis / Gluconeogenesis Pentose phosphate pathway Fructose and mannose metabolism +8 more
		ALMS1	Unknown	36077729	GWAS catalog	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more
		AMPD3	Unknown	36539618	GWAS catalog	Purine metabolism Metabolic pathways Nucleotide metabolism +3 more
		ANK1	Unknown	29228715	GWAS catalog	Proteoglycans in cancer Interaction between L1 and Ankyrins Neurofascin interactions +1 more
		ANKRD11	Unknown	34290314 38411962	GWAS catalog	—
		ANKRD24	Unknown	32887889	GWAS catalog	—
		ANKRD6	Unknown	38411962	GWAS catalog	—
		ANO1	Unknown	25866641 36539618 38872215	GWAS catalog	Stimuli-sensing channels
		ANO3	Unknown	29228715	GWAS catalog	Efferocytosis Stimuli-sensing channels
		ANO4	Unknown	38411962	GWAS catalog	Efferocytosis Stimuli-sensing channels
		ANXA9	Unknown	32887889	GWAS catalog	—
		AOPEP	Unknown	26621817	GWAS catalog	Metabolism of Angiotensinogen to Angiotensins
		ARHGAP10	Unknown	38411962	GWAS catalog	Bacterial invasion of epithelial cells Rho GTPase cycle
		ARHGAP11A-SCG5	Unknown	38872215	GWAS catalog	—
		ARHGAP42	Unknown	30510241 36539618	GWAS catalog	Rho GTPase cycle
		ARHGEF10	Unknown	29228715	GWAS catalog	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARHGEF10L	Unknown	33893285	GWAS catalog	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARHGEF26	Unknown	38538606	GWAS catalog	Bacterial invasion of epithelial cells Salmonella infection NRAGE signals death through JNK +2 more
		ARPC2	Unknown	38872215	GWAS catalog	Endocytosis Tight junction Fc gamma R-mediated phagocytosis +11 more
		ARRDC4	Unknown	38538606	GWAS catalog	—
		ARSJ	Unknown	36539618	GWAS catalog	Glycosphingolipid metabolism The activation of arylsulfatases
		ART1	Unknown	38411962	GWAS catalog	Alpha-defensins
		ASAP1	Unknown	34290314 38538606	GWAS catalog	Endocytosis Fc gamma R-mediated phagocytosis VxPx cargo-targeting to cilium
		ASIP	Unknown	27197191 34290314	GWAS catalog	Melanogenesis
		ATAD5	Unknown	32887889	GWAS catalog	—
		ATE1	Unknown	32887889	GWAS catalog	—
		ATF1	Unknown	20972440 30510241 31089142 36539618 38872215	GWAS catalog	Aldosterone synthesis and secretion Transcriptional misregulation in cancer CREB phosphorylation +1 more
		ATG12	Unknown	—	GenCC	FoxO signaling pathway Autophagy - other Autophagy - animal +6 more
		ATOH1	Unknown	23266556 30510241 36539618 38872215	GWAS catalog	—
		ATP8A2	Unknown	38538606	GWAS catalog	Efferocytosis Ion transport by P-type ATPases
		ATP8B1	Unknown	36929942	GWAS catalog	Ion transport by P-type ATPases
		ATP8B4	Unknown	36077729	GWAS catalog	Neutrophil degranulation Ion transport by P-type ATPases
		ATRN	Unknown	38538606	GWAS catalog	—
		ATXN2	Unknown	26151821 26621817 27197191 29917119 30510241 31089142 34290314 36539618	GWAS catalog	Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases
		AURKA	Unknown	—	ClinVar	Oocyte meiosis Progesterone-mediated oocyte maturation APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 +6 more
		AZGP1	Unknown	37340002	GWAS catalog	Miscellaneous transport and binding events
		B3GLCT	Unknown	33976257	GWAS catalog	Other types of O-glycan biosynthesis Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		BAALC	Unknown	29698419	GWAS catalog	—
		BABAM1	Unknown	27197191	GWAS catalog	Homologous recombination Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +3 more
		BAD	Unknown	34290314	GWAS catalog	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +44 more
RECTUM CANCER	EFO_1000657	ANO1	Unknown	25866641	GWAS catalog	Stimuli-sensing channels

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Colorectal cancer

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