Subtype of: Eosinophilic leukemia

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
Chronic Eosinophilic Leukemia, Not Otherwise Specified	EFO_1000178	ABL1	Unknown	10998848 11669308	Open Targets	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
		AFDN	Unknown	11669308	Open Targets	Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway +4 more
		ASXL1	Unknown	27174585 29088303 30573779	Open Targets	Polycomb repressive complex UCH proteinases
		ATM	Unknown	29088303	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATRX	Unknown	29088303	Open Targets	Cell cycle
		BCOR	Unknown	27174585 29088303	Open Targets	Polycomb repressive complex
		BCR	Unknown	10998848 11669308	Open Targets	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
		BIRC3	Unknown	29088303	Open Targets	Platinum drug resistance NF-kappa B signaling pathway Ubiquitin mediated proteolysis +23 more
		BRD4	Unknown	29088303	Open Targets	—
		CBL	Unknown	27174585 19387008 29088303 30573779	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +22 more
		CCND1	Unknown	29088303	Open Targets	Endocrine resistance FoxO signaling pathway Cell cycle +58 more
		CDKN2A	Unknown	29088303	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CEBPA	Unknown	29088303	Open Targets	Non-alcoholic fatty liver disease Pathways in cancer Transcriptional misregulation in cancer +3 more
		CSF1R	Unknown	29088303	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +10 more
		CSF3R	Unknown	27174585 29088303	Open Targets	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +3 more
		CUX1	Unknown	30573779	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic
		DNMT3A	Unknown	27174585 29088303	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		ETNK1	Unknown	25615281	Open Targets	Glycerophospholipid metabolism Metabolic pathways Synthesis of PE
		ETV6	Unknown	21226763	Open Targets	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		EZH2	Unknown	27174585 29088303 20601953 30573779	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		FAT4	Unknown	29088303	Open Targets	Hippo signaling pathway - multiple species
		FBXW7	Unknown	29088303	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FLT3	Unknown	18706197	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		GATA1	Unknown	29088303	Open Targets	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GATA2	Unknown	27174585 29088303	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		IDH2	Unknown	29088303 30573779	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IKZF1	Unknown	29088303	Open Targets	—
		JAK2	Unknown	18512307 23997080 37470384 18243306 16034466 18450736 18681311 15805263 27174585 15920007 18466967 21376394 29088303 18024388 21264914 30573779	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAK3	Unknown	30573779	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		KIT	Unknown	25615281	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2A	Unknown	11669308	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		LOC100506403	Unknown	29088303	Open Targets	—
		LRP1B	Unknown	29088303	Open Targets	—
		MAPK1	Unknown	29088303	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +161 more
		MED12	Unknown	29088303	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MPL	Unknown	27449473 29088303	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		NF1	Unknown	29088303	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NFKBIE	Unknown	29088303	Open Targets	Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway +6 more
		NOTCH1	Unknown	27174585 29088303	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NRAS	Unknown	27174585	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NTRK3	Unknown	21226763	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		PCM1	Unknown	15805263 16034466	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more
		PDGFRA	Unknown	16856885 21224473 19212337 21818111	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		POLG	Unknown	29088303	Open Targets	Base excision repair
		PRPF40B	Unknown	29088303	Open Targets	Spliceosome
		PTEN	Unknown	29088303	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		RB1	Unknown	29088303	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RMI2	Unknown	30573779	Open Targets	Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +7 more
		SETBP1	Unknown	27174585 29088303	Open Targets	—
		SF3B1	Unknown	27449473 29088303 30573779	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more

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Chronic eosinophilic leukemia, not otherwise specified

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