Charcot-marie-tooth disease

Base excision repair APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway

Cytoskeleton in muscle cells

Neuroactive ligand-receptor interaction Hormone signaling Class B/2 (Secretin family receptors) Synthesis, secretion, and deacylation of Ghrelin +1 more

Cation-coupled Chloride cotransporters Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)

Rho GTPase cycle Neutrophil degranulation

Lysosome

Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system Synthesis of PIPs at the ER membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane +3 more

RAB GEFs exchange GTP for GDP on RABs

Synthesis of PIPs at the ER membrane RAB GEFs exchange GTP for GDP on RABs

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Inositol phosphate metabolism Metabolic pathways Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane +4 more

Endocytosis trans-Golgi Network Vesicle Budding VxPx cargo-targeting to cilium COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic +2 more

Lysosome

Base excision repair APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway

Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system Synthesis of PIPs at the ER membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane +3 more

RAB GEFs exchange GTP for GDP on RABs

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Inositol phosphate metabolism Metabolic pathways Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane +4 more