Subtype of: Central nervous system cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
central nervous system primitive neuroectodermal neoplasm	MONDO_0000640	PPFIBP1	Unknown	25642631 22820256 22722829	Open Targets	Receptor-type tyrosine-protein phosphatases
		PRCC	Unknown	25642631 22820256	Open Targets	Transcriptional misregulation in cancer Renal cell carcinoma mRNA Splicing - Major Pathway
		PRDM1	Unknown	25642631 32291395	Open Targets	Regulation of TP53 Expression
		PRDM16	Unknown	25642631 22722829	Open Targets	Lysine degradation Metabolic pathways Thermogenesis +1 more
		PRDM2	Unknown	25642631	Open Targets	Lysine degradation Metabolic pathways
		PREX2	Unknown	25642631 22722829	Open Targets	Regulation of PTEN stability and activity
		PRKACA	Unknown	22820256 22832583	Open Targets	Endocrine resistance MAPK signaling pathway Ras signaling pathway +95 more
		PRKAR1A	Unknown	26822237 22722829	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		PRKCB	Unknown	25642631 22722829	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +77 more
		PRKD1	Unknown	25642631 22722829	Open Targets	Rap1 signaling pathway Aldosterone synthesis and secretion Chemical carcinogenesis - reactive oxygen species +1 more
		PRPF40B	Unknown	25642631	Open Targets	Spliceosome
		PTCH1	Unknown	22820256 26822237 9041183 19726788 19726761 21163964 33020650 21107850 25642631 9205058 10874314 9233770 22832583	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	22820256 34301788 9331072 25642631 12175345 28481359 22832583	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPN11	Unknown	25642631	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		PTPN13	Unknown	22820256 22722829	Open Targets	Apoptosis Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
		PTPRB	Unknown	25642631	Open Targets	Adherens junction Neutrophil degranulation
		PTPRC	Unknown	25642631 22722829	Open Targets	Cell adhesion molecules T cell receptor signaling pathway Fc gamma R-mediated phagocytosis +5 more
		PTPRD	Unknown	22722829	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRK	Unknown	22722829	Open Targets	EGFR downregulation
		PTPRT	Unknown	25642631 22722829	Open Targets	—
		PWWP2A	Unknown	25642631 22722829	Open Targets	—
		QKI	Unknown	22820256	Open Targets	Signaling by BRAF and RAF fusions
		RABEP1	Unknown	25642631	Open Targets	Endocytosis TBC/RABGAPs
		RAC1	Unknown	25642631	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +89 more
		RAD17	Unknown	25642631	Open Targets	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends +3 more
		RAD50	Unknown	25642631	Open Targets	Homologous recombination Non-homologous end-joining Cellular senescence +14 more
		RAD51B	Unknown	25642631 22722829	Open Targets	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		RAD51C	Unknown	25642631	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +5 more
		RAD51D	Unknown	25642631	Open Targets	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		RAF1	Unknown	25642631	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +93 more
		RANBP2	Unknown	25642631	Open Targets	Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis +32 more
		RAP1GDS1	Unknown	25642631	Open Targets	—
		RARA	Unknown	25642631	Open Targets	Th17 cell differentiation Estrogen signaling pathway Pathways in cancer +6 more
		RASA1	Unknown	25642631 22722829	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more
		RB1	Unknown	25642631 28481359 22832583	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RBM10	Unknown	22820256	Open Targets	—
		RBM15	Unknown	25642631 22820256	Open Targets	—
		RECQL4	Unknown	25642631 22820256	Open Targets	—
		REL	Unknown	25642631	Open Targets	Ras signaling pathway Transcriptional misregulation in cancer Viral carcinogenesis +1 more
		RET	Unknown	25642631 22722829	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		RGPD3	Unknown	25642631	Open Targets	—
		RGS7	Unknown	25642631 22722829	Open Targets	G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
		RHOH	Unknown	25642631	Open Targets	Leukocyte transendothelial migration Salmonella infection Rho GTPase cycle
		RICTOR	Unknown	25642631	Open Targets	mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling +3 more
		RMI2	Unknown	22820256	Open Targets	Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +7 more
		RNF213	Unknown	25642631	Open Targets	Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation
		RNF43	Unknown	22820256 28481359 22722829	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		ROBO2	Unknown	25642631 22832583 22722829	Open Targets	Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
		ROCK1	Unknown	25642631	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway +25 more
		ROS1	Unknown	22820256	Open Targets	—

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Central nervous system primitive neuroectodermal neoplasm

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