Subtype of: Central nervous system cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
central nervous system primitive neuroectodermal neoplasm	MONDO_0000640	COL1A1	Unknown	25642631 22820256	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +26 more
		COL2A1	Unknown	25642631 22722829	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +14 more
		COL3A1	Unknown	25642631	Open Targets	Platelet activation Cytoskeleton in muscle cells Relaxin signaling pathway +16 more
		CPEB3	Unknown	22722829	Open Targets	Oocyte meiosis Progesterone-mediated oocyte maturation
		CREB1	Unknown	25642631	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis +53 more
		CREB3L2	Unknown	22722829	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway +32 more
		CREBBP	Unknown	25642631 22820256 22832583 22722829	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		CRTC3	Unknown	25642631	Open Targets	Human T-cell leukemia virus 1 infection Transcriptional activation of mitochondrial biogenesis Circadian Clock
		CSF1R	Unknown	25642631	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +10 more
		CSF3R	Unknown	22722829	Open Targets	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +3 more
		CSMD3	Unknown	25642631 22722829	Open Targets	—
		CTCF	Unknown	25642631 22722829	Open Targets	—
		CTNNA1	Unknown	25642631	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +9 more
		CTNNA2	Unknown	25642631 22722829	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +6 more
		CTNNB1	Unknown	17172831 11433413 18769486 22820256 23525311 26822237 16685513 21358093 22832583 19293793 16258095 30196423 30446821 23278988 25642631 10759189 15176713 21060032 10666372	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		CTNND1	Unknown	25642631 22722829	Open Targets	Rap1 signaling pathway Adherens junction Leukocyte transendothelial migration +3 more
		CTNND2	Unknown	25642631 22722829	Open Targets	Wnt signaling pathway
		CUL3	Unknown	25642631	Open Targets	Ubiquitin mediated proteolysis Hedgehog signaling pathway Degradation of DVL +4 more
		CUX1	Unknown	22722829	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic
		CYLD	Unknown	25642631 22832583 22722829	Open Targets	NF-kappa B signaling pathway Necroptosis Osteoclast differentiation +9 more
		DAXX	Unknown	25642631	Open Targets	MAPK signaling pathway Apoptosis Parkinson disease +6 more
		DCAF12L2	Unknown	22820256	Open Targets	—
		DCC	Unknown	25642631 22722829	Open Targets	Axon guidance Pathways in cancer Colorectal cancer +3 more
		DCTN1	Unknown	25642631 22722829	Open Targets	Motor proteins Vasopressin-regulated water reabsorption Amyotrophic lateral sclerosis +15 more
		DDB2	Unknown	25642631	Open Targets	Nucleotide excision repair p53 signaling pathway Ubiquitin mediated proteolysis +23 more
		DDR2	Unknown	25642631	Open Targets	Non-integrin membrane-ECM interactions
		DDX10	Unknown	22722829	Open Targets	—
		DDX3X	Unknown	22820256 26822237 22722829 33020650 21163964 25642631 22832583	Open Targets	RIG-I-like receptor signaling pathway Hepatitis B Viral carcinogenesis +1 more
		DDX5	Unknown	25642631	Open Targets	Spliceosome Transcriptional misregulation in cancer Proteoglycans in cancer +3 more
		DDX6	Unknown	22832583	Open Targets	RNA degradation mRNA decay by 5' to 3' exoribonuclease
		DICER1	Unknown	25642631 30446821 22820256 32291395	Open Targets	MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
		DNAJB1	Unknown	25642631	Open Targets	Protein processing in endoplasmic reticulum Influenza A Regulation of HSF1-mediated heat shock response +4 more
		DROSHA	Unknown	25642631	Open Targets	Ribosome biogenesis in eukaryotes Proteoglycans in cancer MicroRNA (miRNA) biogenesis
		EBF1	Unknown	22722829	Open Targets	—
		ECT2L	Unknown	25642631 22820256	Open Targets	—
		EED	Unknown	25642631	Open Targets	Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence +4 more
		EGFR	Unknown	22722829	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		EIF3E	Unknown	22832583	Open Targets	Hepatitis C L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation +4 more
		ELL	Unknown	25642631 22832583	Open Targets	Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events +4 more
		EML4	Unknown	25642631 22820256	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer +1 more
		EP300	Unknown	25642631 22820256 22832583	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		EPAS1	Unknown	22820256	Open Targets	HIF-1 signaling pathway Pathways in cancer Renal cell carcinoma +6 more
		EPHA3	Unknown	25642631 22820256 22722829	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPHA7	Unknown	25642631 22832583	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPS15	Unknown	25642631	Open Targets	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
		ERBB2	Unknown	25642631 22820256	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ERBB4	Unknown	25642631 22722829	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		ERC1	Unknown	25642631 22722829	Open Targets	NF-kappa B signaling pathway
		ERCC2	Unknown	25642631	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		ERCC3	Unknown	22820256	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more

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Central nervous system primitive neuroectodermal neoplasm

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