Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
cecum adenocarcinoma	MONDO_0006028	GRIN2A	Unknown	22810696 26336987 29316426 30239619 25344691 28481359	Open Targets	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		GRM3	Unknown	22810696 25344691	Open Targets	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		GSK3B	Unknown	29316426 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Chemokine signaling pathway +59 more
		H3-3A	Unknown	28481359	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +18 more
		H3-3B	Unknown	28481359	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +18 more
		HERPUD1	Unknown	22810696	Open Targets	Protein processing in endoplasmic reticulum ATF4 activates genes in response to endoplasmic reticulum stress
		HGF	Unknown	28481359 25344691	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HIF1A	Unknown	38725616	Open Targets	HIF-1 signaling pathway Mitophagy - animal Autophagy - animal +19 more
		HIP1	Unknown	22810696	Open Targets	Huntington disease Pathways of neurodegeneration - multiple diseases Clathrin-mediated endocytosis
		HLA-A	Unknown	22810696 29316426 28481359	Open Targets	Endocytosis Phagosome Cellular senescence +25 more
		HLF	Unknown	22810696	Open Targets	—
		HMGA2	Unknown	22810696	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Formation of Senescence-Associated Heterochromatin Foci (SAHF)
		HNF1A	Unknown	28481359 25344691	Open Targets	Maturity onset diabetes of the young
		HNRNPA2B1	Unknown	22810696	Open Targets	Amyotrophic lateral sclerosis mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA +1 more
		HOXA11	Unknown	25344691	Open Targets	Transcriptional misregulation in cancer
		HOXA13	Unknown	30239619	Open Targets	—
		HOXC13	Unknown	22810696	Open Targets	—
		HOXD11	Unknown	22810696	Open Targets	—
		HOXD13	Unknown	25344691	Open Targets	—
		HRAS	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		HSP90AA1	Unknown	25344691	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +56 more
		HSP90AB1	Unknown	25344691	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +26 more
		ID3	Unknown	28481359	Open Targets	TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells NGF-stimulated transcription
		IDH1	Unknown	29967250 28481359 25344691	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IDH2	Unknown	29316426 28481359	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IKBKB	Unknown	25344691	Open Targets	Antifolate resistance MAPK signaling pathway Ras signaling pathway +79 more
		IKZF1	Unknown	29316426 28481359	Open Targets	—
		IL21R	Unknown	22810696	Open Targets	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +2 more
		IL6ST	Unknown	22810696 30239619 25344691	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Signaling pathways regulating pluripotency of stem cells +12 more
		IL7R	Unknown	22810696 28481359 25344691	Open Targets	Cytokine-cytokine receptor interaction FoxO signaling pathway PI3K-Akt signaling pathway +7 more
		IRF4	Unknown	22810696 29316426 28481359	Open Targets	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		IRS4	Unknown	22810696 30239619 25344691	Open Targets	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling +11 more
		ITGAV	Unknown	22810696	Open Targets	Hormone signaling Phagosome Efferocytosis +26 more
		ITK	Unknown	22810696 25344691	Open Targets	Chemokine signaling pathway T cell receptor signaling pathway Leukocyte transendothelial migration +2 more
		JAK1	Unknown	38725616 28481359 29316426 25344691	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK2	Unknown	22810696 28481359 25344691	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAK3	Unknown	38725616 28481359 25344691	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		JAZF1	Unknown	22810696	Open Targets	—
		JUN	Unknown	29316426 25344691 28481359	Open Targets	Endocrine resistance MAPK signaling pathway ErbB signaling pathway +63 more
		KAT6A	Unknown	22810696 25344691 38725616	Open Targets	Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation
		KAT6B	Unknown	29844865	Open Targets	HATs acetylate histones
		KAT7	Unknown	25344691	Open Targets	HATs acetylate histones
		KCNJ5	Unknown	25344691	Open Targets	Circadian entrainment Retrograde endocannabinoid signaling Serotonergic synapse +8 more
		KDM5A	Unknown	22810696 29967250 26336987 29316426 25344691 28481359	Open Targets	HDMs demethylate histones
		KDM5C	Unknown	29967250 25344691 28481359	Open Targets	HDMs demethylate histones
		KDM6A	Unknown	28551381 30239619 29316426 28481359 19330029	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KDR	Unknown	22810696 30038269 25344691 28481359 29844865	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KEAP1	Unknown	38725616 29316426 28481359	Open Targets	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KIAA1549	Unknown	25344691	Open Targets	Signaling by BRAF and RAF fusions
		KIF5B	Unknown	22810696 26336987	Open Targets	Endocytosis Dopaminergic synapse Motor proteins +12 more

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Cecum adenocarcinoma

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