Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
CD4+/CD56+ hematodermic neoplasm	MONDO_0019467	ABL1	Unknown	26164398	Open Targets	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
		APC	Unknown	25115387	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		ASXL1	Unknown	33054115 24072100 30977107 34884997	Open Targets	Polycomb repressive complex UCH proteinases
		ATM	Unknown	33054115 25115387	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATRX	Unknown	24072100	Open Targets	Cell cycle
		BCR	Unknown	26164398	Open Targets	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
		BRAF	Unknown	25115387	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		CALR	Unknown	33598264	Open Targets	Protein processing in endoplasmic reticulum Phagosome Efferocytosis +14 more
		CBLB	Unknown	24072100	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +5 more
		CBLC	Unknown	24072100	Open Targets	Ubiquitin mediated proteolysis Endocytosis
		CDKN2A	Unknown	21900200	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CXCR4	Unknown	33054115	Open Targets	Viral life cycle - HIV-1 Virion - Human immunodeficiency virus Calcium signaling pathway +15 more
		DNMT3A	Unknown	24072100 34884997	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		ETNK1	Unknown	34884997	Open Targets	Glycerophospholipid metabolism Metabolic pathways Synthesis of PE
		ETV6	Unknown	33054115 24072100 34884997	Open Targets	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		EZH2	Unknown	24072100	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		FLT3	Unknown	24072100	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		HRAS	Unknown	34884997	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		IDH1	Unknown	24072100 34884997	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IDH2	Unknown	24072100 25115387 25481493 33054115 34884997	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IKZF1	Unknown	24072100 33054115 34884997	Open Targets	—
		IKZF3	Unknown	33054115 24072100	Open Targets	—
		JAK2	Unknown	24072100 33054115 34884997	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		KDM6A	Unknown	34884997	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KIT	Unknown	24072100	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2A	Unknown	26164398 21831428	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	24072100 25115387 33054115 37029861 34884997	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LOC100506403	Unknown	24072100 34884997	Open Targets	—
		MET	Unknown	33054115 25115387	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MLH1	Unknown	25115387	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MLLT1	Unknown	26164398 21831428	Open Targets	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		NF1	Unknown	34884997	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NOTCH1	Unknown	34884997	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	33054115	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NPM1	Unknown	24072100 29705980	Open Targets	Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere +2 more
		NRAS	Unknown	24072100 25115387 33054115 37029861 34884997	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		RAD21	Unknown	34884997	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		RB1	Unknown	25115387	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RET	Unknown	25115387	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		SF3B1	Unknown	24072100	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SH2B3	Unknown	34884997	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SRSF2	Unknown	24072100 33054115 29705980 34884997	Open Targets	Spliceosome Herpes simplex virus 1 infection Transport of Mature mRNA derived from an Intron-Containing Transcript +4 more
		TET1	Unknown	24072100	Open Targets	—
		TET2	Unknown	24072100 33054115 21275969 34884997 23940084 29705980 30977107 37029861	Open Targets	—
		TP53	Unknown	24072100 25115387 33054115 34884997 21275969	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		U2AF1	Unknown	24072100 34884997	Open Targets	Spliceosome Shigellosis Transport of Mature mRNA derived from an Intron-Containing Transcript +3 more
		VHL	Unknown	25115387	Open Targets	HIF-1 signaling pathway Ubiquitin mediated proteolysis Pathways in cancer +5 more
		ZRSR2	Unknown	33054115 24072100 37029861 30977107 34884997	Open Targets	mRNA Splicing - Minor Pathway

Cd4+/cd56+ hematodermic neoplasm

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