Cardioembolic stroke

Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis +11 more

Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors

Post-translational modification: synthesis of GPI-anchored proteins

The retinoid cycle in cones (daylight vision) Retinoid cycle disease events G alpha (i) signalling events Opsins +1 more

Olfactory transduction Olfactory Signaling Pathway

Olfactory transduction Olfactory Signaling Pathway

NGF processing Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes

HATs acetylate histones Regulation of TP53 Degradation Regulation of TP53 Activity through Association with Co-factors Stabilization of p53 +1 more

TGF-beta signaling pathway TFAP2 (AP-2) family regulates transcription of other transcription factors

Terpenoid backbone biosynthesis Metabolic pathways Peroxisome Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP) +2 more

RNA polymerase Nucleotide excision repair Huntington disease Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Estrogen-dependent gene expression +25 more

Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases +3 more

Endocrine resistance ErbB signaling pathway Chemokine signaling pathway Efferocytosis PI3K-Akt signaling pathway Axon guidance VEGF signaling pathway Focal adhesion Leukocyte transendothelial migration Regulation of actin cytoskeleton Growth hormone synthesis, secretion and action Bacterial invasion of epithelial cells Shigellosis Yersinia infection Amoebiasis Human cytomegalovirus infection Human papillomavirus infection Human immunodeficiency virus 1 infection Pathways in cancer Transcriptional misregulation in cancer Proteoglycans in cancer Chemical carcinogenesis - reactive oxygen species Small cell lung cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis Apoptotic cleavage of cellular proteins Regulation of actin dynamics for phagocytic cup formation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins NCAM signaling for neurite out-growth EPHB-mediated forward signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RAF/MAP kinase cascade MET activates PTK2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling FCGR3A-mediated phagocytosis +37 more

G alpha (q) signalling events G alpha (i) signalling events

G alpha (q) signalling events G alpha (i) signalling events

G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +7 more

Polycomb repressive complex Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription +5 more

Invadopodia formation

Bile secretion Organic anion transport

Synaptic vesicle cycle Na+/Cl- dependent neurotransmitter transporters Defective SLC6A2 causes orthostatic intolerance (OI)

SUMOylation of transcription factors

Cytoskeleton in muscle cells

YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway HIF-1 signaling pathway PI3K-Akt signaling pathway Rheumatoid arthritis Tie2 Signaling RAF/MAP kinase cascade +5 more

Cytokine-cytokine receptor interaction TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Antigen processing: Ubiquitination & Proteasome degradation

cGMP-PKG signaling pathway Axon guidance Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels +2 more

Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Dilated cardiomyopathy Platelet degranulation Striated Muscle Contraction +2 more

Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes

Tyrosine metabolism Metabolic pathways Melanogenesis Melanin biosynthesis +1 more

TCF dependent signaling in response to WNT Ub-specific processing proteases

Endocytosis Pathogenic Escherichia coli infection Yersinia infection Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis +3 more