Brugada syndrome

ABC transporters ATP sensitive Potassium channels ABC-family proteins mediated transport Ion homeostasis Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia +2 more

Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF fusions AURKA Activation by TPX2 +7 more

Cytoskeleton in muscle cells PPARA activates gene expression

MAPK signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Oxytocin signaling pathway Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Presynaptic depolarization and calcium channel opening Phase 0 - rapid depolarisation Phase 2 - plateau phase +7 more

MAPK signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Oxytocin signaling pathway Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Presynaptic depolarization and calcium channel opening Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase +8 more

ErbB signaling pathway Calcium signaling pathway cAMP signaling pathway HIF-1 signaling pathway Oocyte meiosis Efferocytosis Necroptosis Adrenergic signaling in cardiomyocytes Wnt signaling pathway Axon guidance Circadian entrainment Long-term potentiation Neurotrophin signaling pathway Cholinergic synapse Dopaminergic synapse Olfactory transduction Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Melanogenesis Oxytocin signaling pathway Glucagon signaling pathway Aldosterone synthesis and secretion Cushing syndrome Gastric acid secretion Parkinson disease Pathways of neurodegeneration - multiple diseases Amphetamine addiction Tuberculosis Pathways in cancer Proteoglycans in cancer Glioma Diabetic cardiomyopathy Lipid and atherosclerosis HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Ion transport by P-type ATPases Signaling downstream of RAS mutants +44 more

Endocytosis Focal adhesion Prion disease Bacterial invasion of epithelial cells Proteoglycans in cancer Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis Fluid shear stress and atherosclerosis Smooth Muscle Contraction +8 more

Cytoskeleton in muscle cells Protein digestion and absorption Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization +10 more

mTOR signaling pathway Amino acids regulate mTORC1

Hippo signaling pathway Tight junction T cell receptor signaling pathway Human papillomavirus infection Human T-cell leukemia virus 1 infection Viral carcinogenesis Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Synaptic adhesion-like molecules +8 more

Cytoskeleton in muscle cells Arrhythmogenic right ventricular cardiomyopathy Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope +3 more

cGMP-PKG signaling pathway Cellular senescence Tight junction Thyroid hormone signaling pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Physiological factors Factors involved in megakaryocyte development and platelet production +5 more

Glycerophospholipid metabolism Synthesis of PA

cAMP signaling pathway Taste transduction HCN channels

Purine metabolism Pyrimidine metabolism Metabolic pathways Nucleotide metabolism +1 more

Notch signaling pathway Human papillomavirus infection Pathways in cancer Breast cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH4 Intracellular Domain Regulates Transcription +4 more

Calcium signaling pathway Cardiac muscle contraction Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation +1 more

Spinocerebellar ataxia Voltage gated Potassium channels Phase 1 - inactivation of fast Na+ channels

Protein digestion and absorption Phase 3 - rapid repolarisation Phase 2 - plateau phase

Phase 3 - rapid repolarisation Phase 2 - plateau phase

Voltage gated Potassium channels Phase 3 - rapid repolarisation

Cholinergic synapse Oxytocin signaling pathway Renin secretion Gastric acid secretion Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits +5 more

cGMP-PKG signaling pathway ATP sensitive Potassium channels

Adrenergic signaling in cardiomyocytes Cholinergic synapse Gastric acid secretion Pancreatic secretion Protein digestion and absorption Vibrio cholerae infection Voltage gated Potassium channels Phase 3 - rapid repolarisation Phase 2 - plateau phase +6 more

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction African trypanosomiasis Toxoplasmosis Amoebiasis Human papillomavirus infection Pathways in cancer Small cell lung cancer Laminin interactions MET activates PTK2 signaling +8 more

Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Dilated cardiomyopathy Striated Muscle Contraction +1 more

Cytoskeleton in muscle cells

Motor proteins Cytoskeleton in muscle cells

Motor proteins

Lysosome

Cytoskeleton in muscle cells Arrhythmogenic right ventricular cardiomyopathy Keratinization Formation of the cornified envelope +1 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway HIF-1 signaling pathway Phosphatidylinositol signaling system Sphingolipid signaling pathway Phospholipase D signaling pathway mTOR signaling pathway PI3K-Akt signaling pathway Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Wnt signaling pathway Axon guidance VEGF signaling pathway Focal adhesion Gap junction Neutrophil extracellular trap formation Natural killer cell mediated cytotoxicity Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Long-term depression Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Melanogenesis Thyroid hormone synthesis Thyroid hormone signaling pathway Oxytocin signaling pathway Aldosterone synthesis and secretion Relaxin signaling pathway Parathyroid hormone synthesis, secretion and action GnRH secretion AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Aldosterone-regulated sodium reabsorption Endocrine and other factor-regulated calcium reabsorption Salivary secretion Gastric acid secretion Pancreatic secretion Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Amphetamine addiction Morphine addiction Vibrio cholerae infection African trypanosomiasis Amoebiasis Hepatitis B Human cytomegalovirus infection Influenza A Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Glioma Non-small cell lung cancer Hepatocellular carcinoma Choline metabolism in cancer Diabetic cardiomyopathy Lipid and atherosclerosis Calmodulin induced events Disinhibition of SNARE formation SHC1 events in ERBB2 signaling Signaling by SCF-KIT Regulation of KIT signaling EGFR Transactivation by Gastrin Syndecan interactions Acetylcholine regulates insulin secretion Trafficking of GluR2-containing AMPA receptors Depolymerisation of the Nuclear Lamina HuR (ELAVL1) binds and stabilizes mRNA WNT5A-dependent internalization of FZD4 VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Response to elevated platelet cytosolic Ca2+ RET signaling ROBO receptors bind AKAP5 +87 more

Phase 0 - rapid depolarisation

NGF-stimulated transcription

Calcium signaling pathway cAMP signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Apelin signaling pathway Circadian entrainment Insulin secretion Oxytocin signaling pathway Pancreatic secretion Prion disease Pathways of neurodegeneration - multiple diseases Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy Stimuli-sensing channels Ion homeostasis +14 more

Adrenergic signaling in cardiomyocytes Phase 0 - rapid depolarisation

Phase 0 - rapid depolarisation

Phase 0 - rapid depolarisation

Taste transduction Aldosterone-regulated sodium reabsorption Stimuli-sensing channels

Axon guidance Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling +1 more

Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis +2 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Chemokine signaling pathway FoxO signaling pathway Phospholipase D signaling pathway mTOR signaling pathway PI3K-Akt signaling pathway Focal adhesion Gap junction JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway B cell receptor signaling pathway Fc epsilon RI signaling pathway Thermogenesis Neurotrophin signaling pathway Regulation of actin cytoskeleton Insulin signaling pathway GnRH signaling pathway Estrogen signaling pathway Prolactin signaling pathway Relaxin signaling pathway Growth hormone synthesis, secretion and action Alcoholism Hepatitis C Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Endometrial cancer Glioma Prostate cancer Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Choline metabolism in cancer SOS-mediated signalling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB4 signaling Signaling by SCF-KIT Regulation of KIT signaling Signalling to RAS GRB2 events in EGFR signaling SHC1 events in EGFR signaling Downstream signal transduction NRAGE signals death through JNK Rho GTPase cycle GRB2 events in ERBB2 signaling Tie2 Signaling EGFR Transactivation by Gastrin DAP12 signaling SHC-related events triggered by IGF1R Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization GRB2:SOS provides linkage to MAPK signaling for Integrins NCAM signaling for neurite out-growth G alpha (12/13) signalling events Constitutive Signaling by EGFRvIII SHC-mediated cascade:FGFR1 FRS-mediated FGFR1 signaling SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease RAF/MAP kinase cascade Signal attenuation Insulin receptor signalling cascade MET activates RAS signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer RET signaling Interleukin-15 signaling Activated NTRK2 signals through FRS2 and FRS3 Interleukin receptor SHC signaling FLT3 Signaling Constitutive Signaling by Overexpressed ERBB2 Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Antigen activates B Cell Receptor (BCR) leading to generation of second messengers +97 more

YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors

MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway Cell cycle Cellular senescence TGF-beta signaling pathway Hippo signaling pathway AGE-RAGE signaling pathway in diabetic complications Leishmaniasis Chagas disease Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis B Human T-cell leukemia virus 1 infection Pathways in cancer Colorectal cancer Renal cell carcinoma Pancreatic cancer Chronic myeloid leukemia Hepatocellular carcinoma Gastric cancer Inflammatory bowel disease Rheumatoid arthritis Hypertrophic cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy Platelet degranulation Molecules associated with elastic fibres +27 more

MAPK signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Oxytocin signaling pathway Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Presynaptic depolarization and calcium channel opening Phase 0 - rapid depolarisation Phase 2 - plateau phase +7 more

MAPK signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Oxytocin signaling pathway Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Presynaptic depolarization and calcium channel opening Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase +8 more

Cytoskeleton in muscle cells Arrhythmogenic right ventricular cardiomyopathy Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope +3 more

Glycerophospholipid metabolism Synthesis of PA

cAMP signaling pathway Taste transduction HCN channels

Spinocerebellar ataxia Voltage gated Potassium channels Phase 1 - inactivation of fast Na+ channels

Voltage gated Potassium channels Phase 3 - rapid repolarisation

cGMP-PKG signaling pathway ATP sensitive Potassium channels

Cytoskeleton in muscle cells Arrhythmogenic right ventricular cardiomyopathy Keratinization Formation of the cornified envelope +1 more

Adrenergic signaling in cardiomyocytes Phase 0 - rapid depolarisation

Phase 0 - rapid depolarisation

Phase 0 - rapid depolarisation

Taste transduction Aldosterone-regulated sodium reabsorption Stimuli-sensing channels

Glycerophospholipid metabolism Synthesis of PA

Protein digestion and absorption Phase 3 - rapid repolarisation Phase 2 - plateau phase

Phase 0 - rapid depolarisation

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction African trypanosomiasis Toxoplasmosis Amoebiasis Human papillomavirus infection Pathways in cancer Small cell lung cancer Laminin interactions MET activates PTK2 signaling +8 more