Breast cancer

Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Ras signaling pathway Calcium signaling pathway Chemokine signaling pathway NF-kappa B signaling pathway HIF-1 signaling pathway Phosphatidylinositol signaling system Phospholipase D signaling pathway Axon guidance VEGF signaling pathway Osteoclast differentiation Platelet activation Neutrophil extracellular trap formation C-type lectin receptor signaling pathway Natural killer cell mediated cytotoxicity B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Neurotrophin signaling pathway Inflammatory mediator regulation of TRP channels Thyroid hormone signaling pathway AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Vibrio cholerae infection Epithelial cell signaling in Helicobacter pylori infection Shigellosis Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Glioma Non-small cell lung cancer Hepatocellular carcinoma GPVI-mediated activation cascade Toll Like Receptor 4 (TLR4) Cascade Synthesis of IP3 and IP4 in the cytosol Generation of second messenger molecules Role of phospholipids in phagocytosis DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) signaling Dectin-2 family FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers +49 more

Synthesis of PIPs at the plasma membrane

PPAR signaling pathway Efferocytosis AMPK signaling pathway Longevity regulating pathway Osteoclast differentiation Thermogenesis Non-alcoholic fatty liver disease Huntington disease Pathways in cancer Transcriptional misregulation in cancer Thyroid cancer Lipid and atherosclerosis PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of PTEN gene transcription +13 more

mRNA Splicing - Major Pathway

Chemokine signaling pathway Kaposi sarcoma-associated herpesvirus infection NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events +2 more

Wnt signaling pathway

Rap1 signaling pathway Endocytosis Hippo signaling pathway Tight junction Platelet activation Insulin signaling pathway Human papillomavirus infection Pre-NOTCH Transcription and Translation p75NTR recruits signalling complexes Tight junction interactions +7 more

RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Post-translational modification: synthesis of GPI-anchored proteins

Ras signaling pathway Phospholipase D signaling pathway Efferocytosis Axon guidance C-type lectin receptor signaling pathway JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway Leukocyte transendothelial migration Neurotrophin signaling pathway Adipocytokine signaling pathway Insulin resistance Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Herpes simplex virus 1 infection Proteoglycans in cancer Chemical carcinogenesis - reactive oxygen species Renal cell carcinoma Chronic myeloid leukemia PD-L1 expression and PD-1 checkpoint pathway in cancer Interleukin-6 signaling PI3K Cascade MAPK3 (ERK1) activation MAPK1 (ERK2) activation GPVI-mediated activation cascade PIP3 activates AKT signaling Spry regulation of FGF signaling Signaling by SCF-KIT GAB1 signalosome Downstream signal transduction PECAM1 interactions Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer Costimulation by the CD28 family CTLA4 inhibitory signaling PD-1 signaling Platelet sensitization by LDL Interleukin-3, Interleukin-5 and GM-CSF signaling PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Interleukin-20 family signaling MET activates PTPN11 Regulation of RUNX1 Expression and Activity Interleukin-37 signaling Interferon alpha/beta signaling Regulation of IFNA signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon +56 more

Cell adhesion molecules Adherens junction

Type I diabetes mellitus Neutrophil degranulation

Spliceosome

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation +3 more

Maturity onset diabetes of the young

Rho GTPase cycle Interleukin-4 and Interleukin-13 signaling

Insulin secretion

Ras signaling pathway RAB GEFs exchange GTP for GDP on RABs

Antigen processing: Ubiquitination & Proteasome degradation

Th17 cell differentiation Circadian rhythm Spinocerebellar ataxia Inflammatory bowel disease RORA activates gene expression PPARA activates gene expression Nuclear Receptor transcription pathway Circadian Clock SUMOylation of intracellular receptors Interleukin-4 and Interleukin-13 signaling +7 more

Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +10 more

ATP-dependent chromatin remodeling Deposition of new CENPA-containing nucleosomes at the centromere

Telomere Extension By Telomerase Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Steroid biosynthesis Metabolic pathways Activation of gene expression by SREBF (SREBP) Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol +2 more

Apoptosis Apoptosis - multiple species Release of apoptotic factors from the mitochondria SMAC, XIAP-regulated apoptotic response +1 more

Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production

FoxO signaling pathway Cell cycle Ubiquitin mediated proteolysis mTOR signaling pathway Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Small cell lung cancer APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 SCF(Skp2)-mediated degradation of p27/p21 Ub-specific processing proteases Orc1 removal from chromatin Cyclin D associated events in G1 Regulation of RUNX2 expression and activity Neddylation Antigen processing: Ubiquitination & Proteasome degradation +13 more

Synaptic vesicle cycle Glutamatergic synapse Amyotrophic lateral sclerosis Huntington disease Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides +4 more

Choline metabolism in cancer Abacavir transmembrane transport Organic cation transport

Sodium/Calcium exchangers

Melanin biosynthesis

Oocyte meiosis

TGF-beta signaling pathway Hippo signaling pathway Signaling by BMP Downregulation of TGF-beta receptor signaling SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Ub-specific processing proteases +3 more

Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis +2 more

Processing of SMDT1