Bone marrow failure | Gene-Disease Associations & Pathways | GeDiPNet

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Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
Bone marrow failure	HP:0005528	BRCA1	Unknown	32086639 32048120	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRCA2	Unknown	32086639 32048120	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		CTC1	Unknown	22267198 22387016 22532422 22899577 32048120 32086639	Open Targets	Telomere C-strand synthesis initiation
		DNAJC21	Unknown	27346687 28062395 29700810	Open Targets	—
		ERCC4	Unknown	32086639 32048120	Open Targets	Nucleotide excision repair Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +4 more
		FANCA	Unknown	16493006	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCB	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCD2	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
		FANCE	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCF	Unknown	28297620 27881370 32086639 32048120	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCG	Unknown	28297620 27881370 16493006	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCI	Unknown	28297620 27881370 32086639 32048120	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
		FANCL	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Ubiquitin mediated proteolysis Fanconi Anemia Pathway
		FANCM	Unknown	28297620 27881370 32086639 32048120	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		LOC105376156	Unknown	16493006 27881370	Open Targets	—
		MYSM1	Unknown	26474655 26220525 24288411 28115216 22184403 28446309	Open Targets	Metalloprotease DUBs
		NPM1	Unknown	31570891	Open Targets	Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere +2 more
		PALB2	Unknown	28297620 27881370	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +3 more
		RAD51C	Unknown	28297620 27881370	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +5 more
		SAMD9	Unknown	29266745 29535429 28487541 29175836 32086639 32048120	Open Targets	—
		SAMD9L	Unknown	31874111 36969289 32086639 32048120 28202457	Open Targets	—
		SLX4	Unknown	28297620 27881370	Open Targets	Fanconi anemia pathway Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
		STN1	Unknown	32086639 32048120	Open Targets	Telomere C-strand synthesis initiation
		TERC	Unknown	11574891 12090986 12525685 16332973 32048120 32086639	Open Targets	Pathways in cancer Hepatocellular carcinoma Gastric cancer
		WRAP53	Unknown	21205863 29514627 32048120 32086639	Open Targets	Telomere Extension By Telomerase