Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
blast phase chronic myelogenous leukemia, BCR-ABL1 positive	MONDO_0006115	ABL1	Unknown	22382182 21264552 23044928 21442193 11853795 9544977 2013978 19557636 21674858 20659155 23009571 21156844 15949566 32943879 20962862 21221851 19531657 23540562 9519792 16475128 12692682 23190221 14745431 10583263 10468864 19048492 17339191 15284852 19373669 9858233 25006280 11423618 25629972 23676790 23433665 11964322 11378554 12823349 17530620 20697894 22713161 19801694 12688366 24109527 12204532 25197554 22691121 2223646	Open Targets	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
		AMER1	Unknown	32943879	Open Targets	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane +8 more
		ASXL1	Unknown	32943879 21346257 24212482 20410925	Open Targets	Polycomb repressive complex UCH proteinases
		ATM	Unknown	32943879	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		BCOR	Unknown	25381062	Open Targets	Polycomb repressive complex
		BCORL1	Unknown	32943879	Open Targets	Polycomb repressive complex
		BCR	Unknown	15949566 11378554 25006280 10583263 10468864 17530620 22382182 19048492 12688366 24109527 9544977 2013978 15284852 19531657 9858233 21674858 9519792 25197554 16475128 2223646	Open Targets	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
		CBL	Unknown	21346257	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +22 more
		CBLB	Unknown	21346257	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +5 more
		CDKN2A	Unknown	10069444 7632963 8555065 7630199	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CREBBP	Unknown	21390130	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		EP300	Unknown	32943879	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		ETV6	Unknown	9067587 9326218 8982044 12823349	Open Targets	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		FAT1	Unknown	32943879	Open Targets	—
		FBXO11	Unknown	9510473	Open Targets	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FLT3	Unknown	23796006	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		GATA1	Unknown	17408401	Open Targets	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GATA2	Unknown	24634115 18250304 32943879	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		IDH1	Unknown	21346257	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IDH2	Unknown	20962862 21346257 32943879	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IKZF1	Unknown	18408710 32943879 20962862	Open Targets	—
		IKZF3	Unknown	24212482	Open Targets	—
		JAK2	Unknown	9326218 20962862 21798133	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAK3	Unknown	20400977	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		KIT	Unknown	32943879	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2A	Unknown	32943879	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	32943879	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		LOC100506403	Unknown	18250304 32943879 18202228 10068652 9067587 39327604 8982044	Open Targets	—
		MAX	Unknown	24634115	Open Targets	Polycomb repressive complex MAPK signaling pathway Pathways in cancer +6 more
		MLH1	Unknown	32943879	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MSH6	Unknown	9510473	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		NF1	Unknown	32943879	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NOTCH1	Unknown	39327604 32943879	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NPM1	Unknown	19421226	Open Targets	Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere +2 more
		NRAS	Unknown	32943879	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NT5C2	Unknown	32943879	Open Targets	Purine metabolism Pyrimidine metabolism Nicotinate and nicotinamide metabolism +4 more
		PBX1	Unknown	7894030	Open Targets	Efferocytosis Cortisol synthesis and secretion Cushing syndrome +3 more
		PHF6	Unknown	22928734	Open Targets	ATP-dependent chromatin remodeling
		PIK3CA	Unknown	21299849	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PTPN11	Unknown	25381062	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		RAD21	Unknown	25381062	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		SETBP1	Unknown	23832012 32943879	Open Targets	—
		SF3B1	Unknown	25381062 21995386	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		STAG2	Unknown	23955599	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		TCF3	Unknown	7894030	Open Targets	Signaling pathways regulating pluripotency of stem cells Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer +2 more
		TENT5C	Unknown	32943879	Open Targets	—
		TET2	Unknown	21346257 32943879	Open Targets	—
		TP53	Unknown	2040694 32943879 24212482 11681414 7658697 25381062	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TP63	Unknown	11681414	Open Targets	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		U2AF1	Unknown	32943879	Open Targets	Spliceosome Shigellosis Transport of Mature mRNA derived from an Intron-Containing Transcript +3 more

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Blast phase chronic myelogenous leukemia, bcr-abl1 positive

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