Biliary tract cancer

Type I hemidesmosome assembly Keratinization Formation of the cornified envelope

Post-translational modification: synthesis of GPI-anchored proteins

MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction RIG-I-like receptor signaling pathway Neurotrophin signaling pathway GnRH signaling pathway Growth hormone synthesis, secretion and action Hepatitis B Human T-cell leukemia virus 1 infection MyD88:MAL(TIRAP) cascade initiated on plasma membrane FCERI mediated MAPK activation TRAF6 mediated NF-kB activation TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane +11 more

PI3K-Akt signaling pathway Apoptosis JAK-STAT signaling pathway MicroRNAs in cancer Interleukin-4 and Interleukin-13 signaling +2 more

Lysine degradation Metabolic pathways MAPK signaling pathway Pathways in cancer Chronic myeloid leukemia PKMTs methylate histone lysines Regulation of PTEN gene transcription +4 more

Endocrine resistance IL-17 signaling pathway TNF signaling pathway Leukocyte transendothelial migration Estrogen signaling pathway Relaxin signaling pathway Hepatitis B Pathways in cancer Transcriptional misregulation in cancer Proteoglycans in cancer MicroRNAs in cancer Prostate cancer Bladder cancer Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis Signaling by SCF-KIT Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Extra-nuclear estrogen signaling +22 more

SUMOylation of transcription cofactors RHO GTPases Activate Formins

Cysteine and methionine metabolism Metabolic pathways Methionine salvage pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation +1 more

Mitophagy - animal

Motor proteins Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation SLIT2:ROBO1 increases RHOA activity FCGR3A-mediated phagocytosis +2 more

RORA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock +4 more

Ubiquitin mediated proteolysis Glycogen synthesis Myoclonic epilepsy of Lafora

Melanin biosynthesis

Olfactory transduction Olfactory Signaling Pathway

Chromatin modifying enzymes

Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange +3 more

HATs acetylate histones Regulation of TP53 Degradation Regulation of TP53 Activity through Association with Co-factors Stabilization of p53 +1 more

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways Attachment of GPI anchor to uPAR

Signaling pathways regulating pluripotency of stem cells

RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Post-translational modification: synthesis of GPI-anchored proteins

Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Factors involved in megakaryocyte development and platelet production +4 more

Spliceosome

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation +3 more

Rho GTPase cycle Interleukin-4 and Interleukin-13 signaling

Antigen processing: Ubiquitination & Proteasome degradation

Apoptosis Apoptosis - multiple species Release of apoptotic factors from the mitochondria SMAC, XIAP-regulated apoptotic response +1 more

Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production

Melanin biosynthesis

Oocyte meiosis

TGF-beta signaling pathway Hippo signaling pathway Signaling by BMP Downregulation of TGF-beta receptor signaling SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Ub-specific processing proteases +3 more

Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes

Telomere C-strand synthesis initiation

MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation Toll-like receptor signaling pathway NOD-like receptor signaling pathway IL-17 signaling pathway TNF signaling pathway Alcoholic liver disease Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection Leishmaniasis Toxoplasmosis Hepatitis B Measles Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Lipid and atherosclerosis Nuclear signaling by ERBB4 NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation +33 more

Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer Hepatocellular carcinoma Gastric cancer Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex +4 more

Endocrine resistance Platinum drug resistance MAPK signaling pathway Sphingolipid signaling pathway Cell cycle p53 signaling pathway Mitophagy - animal PI3K-Akt signaling pathway Apoptosis Longevity regulating pathway Ferroptosis Cellular senescence Wnt signaling pathway Neurotrophin signaling pathway Thyroid hormone signaling pathway Parkinson disease Amyotrophic lateral sclerosis Huntington disease Shigellosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Colorectal cancer Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Basal cell carcinoma Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis Activation of NOXA and translocation to mitochondria Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence DNA Damage/Telomere Stress Induced Senescence SUMOylation of transcription factors Autodegradation of the E3 ubiquitin ligase COP1 TP53 Regulates Metabolic Genes Ub-specific processing proteases Ovarian tumor domain proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Expression Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation G2/M DNA damage checkpoint G2/M Checkpoints Stabilization of p53 Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional Regulation by VENTX RUNX3 regulates CDKN1A transcription Regulation of PTEN gene transcription +85 more