Biliary tract cancer

NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Melanogenesis

Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases

Miscellaneous transport and binding events

Homologous recombination Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint +3 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance ErbB signaling pathway Ras signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Autophagy - animal PI3K-Akt signaling pathway Apoptosis VEGF signaling pathway Focal adhesion Neurotrophin signaling pathway Insulin signaling pathway Thyroid hormone signaling pathway Alzheimer disease Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Human papillomavirus infection Herpes simplex virus 1 infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Prostate cancer Melanoma Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Hepatocellular carcinoma Lipid and atherosclerosis Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK Constitutive Signaling by AKT1 E17K in Cancer +44 more

EGFR tyrosine kinase inhibitor resistance FoxO signaling pathway PI3K-Akt signaling pathway Apoptosis Apoptosis - multiple species Non-alcoholic fatty liver disease Epstein-Barr virus infection Pathways in cancer MicroRNAs in cancer Colorectal cancer Activation of BIM and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK Signaling by BRAF and RAF fusions Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription +13 more

Homologous recombination Fanconi anemia pathway Pathways in cancer Pancreatic cancer Breast cancer HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange +7 more

Platinum drug resistance p53 signaling pathway Apoptosis Apoptosis - multiple species Necroptosis Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway IL-17 signaling pathway TNF signaling pathway Non-alcoholic fatty liver disease Alcoholic liver disease Alzheimer disease Huntington disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Legionellosis Chagas disease Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Viral myocarditis Lipid and atherosclerosis Apoptotic cleavage of cellular proteins Caspase activation via Death Receptors in the presence of ligand NOD1/2 Signaling Pathway TRIF-mediated programmed cell death Caspase-mediated cleavage of cytoskeletal proteins Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling CLEC7A/inflammasome pathway Regulation of necroptotic cell death Dimerization of procaspase-8 Activation, myristolyation of BID and translocation to mitochondria Apoptotic execution phase FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 +53 more

Sphingolipid metabolism Metabolic pathways Sphingolipid signaling pathway Sphingolipid de novo biosynthesis +1 more

Viral life cycle - HIV-1 Virion - Hepatitis viruses Endocytosis Necroptosis Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Sealing of the nuclear envelope (NE) by ESCRT-III +6 more

Legionellosis

Neddylation

Neurexins and neuroligins

Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification LTC4-CYSLTR mediated IL4 production

Trafficking of AMPA receptors Neurexins and neuroligins

Axon guidance EPH-Ephrin signaling EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells +2 more

Endocrine resistance Hormone signaling Estrogen signaling pathway Prolactin signaling pathway Thyroid hormone signaling pathway Endocrine and other factor-regulated calcium reabsorption Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - receptor activation Breast cancer Nuclear signaling by ERBB4 PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors RUNX1 regulates estrogen receptor mediated transcription ESR-mediated signaling RUNX1 regulates transcription of genes involved in WNT signaling Regulation of RUNX2 expression and activity Extra-nuclear estrogen signaling Estrogen-dependent gene expression +21 more

Fanconi anemia pathway Fanconi Anemia Pathway

Polycomb repressive complex

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway Endocytosis PI3K-Akt signaling pathway Signaling pathways regulating pluripotency of stem cells Regulation of actin cytoskeleton Pathways in cancer Prostate cancer Gastric cancer Central carbon metabolism in cancer PI3K Cascade PIP3 activates AKT signaling FGFR2c ligand binding and activation FGFR2b ligand binding and activation Signaling by FGFR2 amplification mutants Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR2 PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling Negative regulation of FGFR2 signaling Signaling by FGFR2 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR2 fusions +26 more

MicroRNAs in cancer Transcriptional regulation of pluripotent stem cells

Porphyrin metabolism Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis

Glycine, serine and threonine metabolism Pyruvate metabolism Glyoxylate and dicarboxylate metabolism Metabolic pathways Glyoxylate metabolism and glycine degradation +2 more

Calcium signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Gap junction Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Alzheimer disease Huntington disease Pathways of neurodegeneration - multiple diseases G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins +10 more

Endocytosis Phagosome Cellular senescence Cell adhesion molecules Antigen processing and presentation Natural killer cell mediated cytotoxicity Type I diabetes mellitus Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Viral carcinogenesis Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Viral myocarditis ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC +24 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Maturity onset diabetes of the young

Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA

Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Interferon alpha/beta signaling +1 more

Voltage gated Potassium channels

Adrenergic signaling in cardiomyocytes Cholinergic synapse Gastric acid secretion Pancreatic secretion Protein digestion and absorption Vibrio cholerae infection Voltage gated Potassium channels Phase 3 - rapid repolarisation Phase 2 - plateau phase +6 more

Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins