Subtype of: Thyroid neoplasms

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
benign thyroid gland neoplasm	MONDO_0006107	AKT1	Unknown	19913280	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		ALK	Unknown	27283500 24475247	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		APC	Unknown	24834793	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		BRAF	Unknown	20518413 17054470 12907632 15356020 21239517 21751431 21707687 22535974 20042852 29085338 27283500 12881714 19913280 19269016 22925390 17956956 14996725 33052631	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA2	Unknown	27283500	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		CCDC6	Unknown	11747322 20099311 23966419 22961909 25111330 8545102 11443191 9516913 21048359 11788677 20703476 24915144 21411555 15788648 17727338 21173509 9001272 10951397 9508203 16015630 10773666 12057919 9466701	Open Targets	Pathways in cancer Thyroid cancer
		DICER1	Unknown	29187512 29538609 26545620 31893257 26886166	Open Targets	MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
		EIF1AX	Unknown	29669480	Open Targets	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits +3 more
		FCRL4	Unknown	27283500	Open Targets	—
		FGFR1	Unknown	27283500	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +32 more
		FLI1	Unknown	27283500	Open Targets	Transcriptional misregulation in cancer
		GNAS	Unknown	7745026 8501149 1910478 2116665 18694911 14514342 19550078 16990652 11434721 9685222 10566665	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		GOLGA5	Unknown	10773666	Open Targets	Intra-Golgi traffic
		HRAS	Unknown	12727991 7714109 2283998 28975450 22650231 2648253 33052631 29085338 2183158 1452458 8936664 7630645 9724079 29669480 12788883 25487739 2021946 31085772	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		IDH1	Unknown	24834793	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		KMT2A	Unknown	27283500	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	27717198 7559096 28975450 2648253 10468914 27283500 2183158 17317825 29085338 33052631 31085772	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		MDM2	Unknown	27283500	Open Targets	Endocrine resistance Platinum drug resistance FoxO signaling pathway +35 more
		NCOA1	Unknown	27283500	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway Pathways in cancer +18 more
		NCOA2	Unknown	27283500	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway RORA activates gene expression +14 more
		NCOA4	Unknown	21173509 9001272 9516913 11747322 24915144 20099311 20703476 16015630 10773666 21048359 21411555 22961909 23966419 12057919 25111330 9466701 11788677 15788648 17727338 8545102 11443191	Open Targets	Ferroptosis Pathways in cancer Thyroid cancer
		NR4A3	Unknown	27283500	Open Targets	Transcriptional misregulation in cancer Nuclear Receptor transcription pathway RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
		NRAS	Unknown	12727991 17651453 27283500 8936664 7630645 24834793 15320975 16402937 1452458 29085338 12788883 23888303 24915144 22650231 2648253 17317825 2183158 15763659 19913280 8761289 9861322 2283998 11531932 24898513 7704243 33052631 25487739 2021946 31085772	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NSD1	Unknown	27283500	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NTRK1	Unknown	11216646 8740514 10646882	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NUP98	Unknown	27283500	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		PAX8	Unknown	16728576 10958784 23881852 12519876 24915144 15256783 20099311 23966419 22961909 12161538 19963130 12170088 21983636 12970322	Open Targets	Thyroid hormone synthesis Pathways in cancer Transcriptional misregulation in cancer +1 more
		PIK3CA	Unknown	33052631 17317825	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PPARG	Unknown	16728576 10958784 23881852 12519876 24915144 15256783 20099311 23966419 22961909 27283500 12161538 19963130 12170088 21983636 12970322	Open Targets	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
		PRKAR1A	Unknown	11747322 9516913 10773666 11788677 9466701 8545102	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		PTEN	Unknown	24834793	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		RET	Unknown	11747322 20099311 23966419 22961909 25111330 8545102 11443191 9516913 21048359 11788677 20703476 24915144 21411555 15788648 17727338 21173509 9001272 10951397 9508203 16015630 10773666 12057919 9466701	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		ROS1	Unknown	27283500	Open Targets	—
		SMAD4	Unknown	15940269	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		STRN	Unknown	24475247	Open Targets	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +2 more
		TFG	Unknown	11216646 8740514 10646882	Open Targets	Pathways in cancer Thyroid cancer COPII-mediated vesicle transport
		TP53	Unknown	9360526	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TPM3	Unknown	8740514 10646882	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +7 more
		TPR	Unknown	11216646 8740514 10646882	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer +27 more
		TSHR	Unknown	9467563 7714109 7989485 10319940 27283500 8045989 8413627 8636365 14514342 16284436 8989278 16235153 22001338 19550078 10566665 10595453 7800007 24915144 18694911 19492584 11022192 19191749 11434721 9224711 9398745 9294132 17018437 9360556 16990652	Open Targets	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
		ZNF331	Unknown	27283500	Open Targets	Generic Transcription Pathway

Benign thyroid gland neoplasm

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