Subtype of: Astrocytoma · Glioblastoma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
astrocytoma (excluding glioblastoma)	MONDO_0019781	FNBP1	Unknown	25642631	Open Targets	Shigellosis Clathrin-mediated endocytosis
		FOXL2	Unknown	25642631	Open Targets	SUMOylation of transcription factors
		FOXO3	Unknown	29973652	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway FoxO signaling pathway +26 more
		FOXO4	Unknown	25642631	Open Targets	Ras signaling pathway FoxO signaling pathway Shigellosis +7 more
		FOXP1	Unknown	29973652 24880341	Open Targets	MicroRNAs in cancer Transcriptional regulation of pluripotent stem cells
		FUBP1	Unknown	25642631 22588899	Open Targets	—
		FUS	Unknown	25642631	Open Targets	mRNA surveillance pathway Spliceosome Amyotrophic lateral sclerosis +3 more
		GAS7	Unknown	25642631	Open Targets	—
		GATA2	Unknown	25642631	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GLI1	Unknown	25642631	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Pathways in cancer +5 more
		GMPS	Unknown	25642631	Open Targets	Purine metabolism Drug metabolism - other enzymes Metabolic pathways +2 more
		GNAS	Unknown	25642631	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		GOLPH3	Unknown	25642631	Open Targets	—
		GPC5	Unknown	25642631	Open Targets	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation +7 more
		GPHN	Unknown	23104868	Open Targets	Folate biosynthesis Metabolic pathways Biosynthesis of cofactors +2 more
		GRIN2A	Unknown	25642631	Open Targets	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		H3-3A	Unknown	26087904 25231549 25479829 38447592 24705252 27392443 25667294 26231952 26297251 23417712 22661320 31350684 24880341 28506301	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +18 more
		H3C2	Unknown	24705252	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +27 more
		HEY1	Unknown	25642631	Open Targets	Notch signaling pathway Human papillomavirus infection Pathways in cancer +4 more
		HIF1A	Unknown	25642631	Open Targets	HIF-1 signaling pathway Mitophagy - animal Autophagy - animal +19 more
		HLA-A	Unknown	26487540	Open Targets	Endocytosis Phagosome Cellular senescence +25 more
		HNF1A	Unknown	25642631	Open Targets	Maturity onset diabetes of the young
		HOXC13	Unknown	25642631	Open Targets	—
		HRAS	Unknown	25642631 25036404	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		HSP90AA1	Unknown	26487540	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +56 more
		HSP90AB1	Unknown	25642631	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +26 more
		IDH1	Unknown	21643842 26617880 38414131 23370430 22772731 27441955 19915484 22591444 22113362 24714777 28236063 35128400 22904127 29026176 32742729 26919320 37554222 20874727 29683790 28874004 21717448 19543740 38581197 34020723 21760534 28125199 23600211 24460285 28915660 22821383 24857351 20131059 19340432 37822669 22528790 36974551 29527387 22825915 37792958 22588899 20077503 27460417 23764841 23486690 23451940 25257301 28663030 23840696 34301788 29600313 23104868 33193845 29615461 24004584 24868540 24767714 32888020 25012071 24140581 23330999 22844452 20514489 21569770 20431032 24532263 25427834 22426639 23417712 35261853 23307057 25085214 21710625 25192052 22281806 28866063 19435942 35262523 21558404 21913188 29031038 24311631 21107199 28679024 29263181 37077830 22710963	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IDH2	Unknown	22825915 23307057 22772731 33193845 26919320 26617880 19554337 23764841 25192052 20131059 35262523 37077830	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IGF2BP2	Unknown	23592488	Open Targets	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
		IKBKB	Unknown	37792958 25642631	Open Targets	Antifolate resistance MAPK signaling pathway Ras signaling pathway +79 more
		IKZF1	Unknown	37792958	Open Targets	—
		IRF4	Unknown	25642631	Open Targets	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		IRS4	Unknown	25642631 23104868	Open Targets	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling +11 more
		ITGAV	Unknown	25642631	Open Targets	Hormone signaling Phagosome Efferocytosis +26 more
		ITK	Unknown	25642631	Open Targets	Chemokine signaling pathway T cell receptor signaling pathway Leukocyte transendothelial migration +2 more
		JAK1	Unknown	25642631 24705252	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK3	Unknown	25642631	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		KAT6A	Unknown	29973652	Open Targets	Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation
		KAT6B	Unknown	25642631	Open Targets	HATs acetylate histones
		KCNJ5	Unknown	32069381	Open Targets	Circadian entrainment Retrograde endocannabinoid signaling Serotonergic synapse +8 more
		KDM5A	Unknown	25642631 26487540	Open Targets	HDMs demethylate histones
		KDM5C	Unknown	25642631	Open Targets	HDMs demethylate histones
		KDM6A	Unknown	25642631 29973652 24285547	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KDR	Unknown	25642631	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KEAP1	Unknown	25642631	Open Targets	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KIAA1549	Unknown	37792958 22591444 27577993 19016743 21884820 22568401 25642631 24767714 19373855 19543740 24532263 20068183 21610142 22710963	Open Targets	Signaling by BRAF and RAF fusions
		KIT	Unknown	25642631	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2A	Unknown	25642631	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	25642631 29973652 26487540	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	25642631 29973652 23592488	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more

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Astrocytoma (excluding glioblastoma)

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