Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
appendix adenocarcinoma	MONDO_0006087	KMT2D	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	29327707 31111538 26160192 18042066 12065772 30239619 21443421 31491041 29634977 28481359 8651354	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LATS2	Unknown	28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LIFR	Unknown	30239619	Open Targets	Cytokine-cytokine receptor interaction Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway +2 more
		MAP2K4	Unknown	28481359	Open Targets	MAPK signaling pathway ErbB signaling pathway Toll-like receptor signaling pathway +21 more
		MAPK1	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +161 more
		MLH1	Unknown	28481359	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MTOR	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		NCOR1	Unknown	28481359	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NF1	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NOTCH1	Unknown	28481359	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NTRK1	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NTRK2	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
		NTRK3	Unknown	28481359	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		PAX5	Unknown	28481359	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PDE4DIP	Unknown	30239619	Open Targets	—
		PDGFRA	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		PHF6	Unknown	30239619	Open Targets	ATP-dependent chromatin remodeling
		PIK3CA	Unknown	29327707 28481359 31491041	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3CB	Unknown	28481359	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +126 more
		PPP2R1A	Unknown	28481359	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PPP6C	Unknown	28481359	Open Targets	COPII-mediated vesicle transport
		PRDM1	Unknown	28481359	Open Targets	Regulation of TP53 Expression
		PTCH1	Unknown	28481359	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	31491041	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPN11	Unknown	28481359	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		PTPRT	Unknown	28481359	Open Targets	—
		RASA1	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more
		RB1	Unknown	28481359	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RNF43	Unknown	28481359	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		ROS1	Unknown	28481359	Open Targets	—
		SDHAF2	Unknown	28481359	Open Targets	—
		SDHB	Unknown	28481359	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SETD2	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SIX1	Unknown	30239619	Open Targets	Transcriptional misregulation in cancer
		SMAD2	Unknown	28481359	Open Targets	Cell cycle Endocytosis Cellular senescence +30 more
		SMAD3	Unknown	28481359	Open Targets	FoxO signaling pathway Cell cycle Endocytosis +34 more
		SMAD4	Unknown	14647445 30239619 28481359 31491041	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SMARCA4	Unknown	28481359	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMARCB1	Unknown	28481359	Open Targets	ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis +3 more
		SPOP	Unknown	28481359	Open Targets	Hedgehog signaling pathway Hedgehog 'on' state
		STAT3	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway HIF-1 signaling pathway +53 more
		STK11	Unknown	28481359	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		TCF7L2	Unknown	28481359	Open Targets	Wnt signaling pathway Hippo signaling pathway Adherens junction +26 more
		TET1	Unknown	28481359	Open Targets	—
		TGFBR2	Unknown	28481359	Open Targets	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +28 more
		TOP1	Unknown	28481359	Open Targets	SUMOylation of DNA replication proteins
		TP53	Unknown	31111538 26160192 16260276 30239619 29327707 29634977 28481359 31491041	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TSC2	Unknown	28481359	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		TSHR	Unknown	28481359	Open Targets	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more

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Appendix adenocarcinoma

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