Subtype of: Lung cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
anaplastic lung carcinoma	EFO_1000016	DNM2	Unknown	29681454	Open Targets	Phospholipase D signaling pathway Endocytosis Fc gamma R-mediated phagocytosis +13 more
		DROSHA	Unknown	29681454	Open Targets	Ribosome biogenesis in eukaryotes Proteoglycans in cancer MicroRNA (miRNA) biogenesis
		EBF1	Unknown	29681454	Open Targets	—
		ECT2L	Unknown	29681454	Open Targets	—
		EPHA3	Unknown	16140923 25969368 28481359 29681454	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPHA7	Unknown	23856246	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPS15	Unknown	29681454	Open Targets	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
		ERBB2	Unknown	19096300 24481316 28481359 28892047 29420467 29535832 33200540	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ERCC2	Unknown	29681454	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		ERCC5	Unknown	29681454	Open Targets	Nucleotide excision repair Formation of Incision Complex in GG-NER Dual Incision in GG-NER +1 more
		ESR1	Unknown	29681454	Open Targets	Endocrine resistance Hormone signaling Estrogen signaling pathway +21 more
		ETV1	Unknown	29681454	Open Targets	Transcriptional misregulation in cancer
		EWSR1	Unknown	29681454	Open Targets	Transcriptional misregulation in cancer
		EXT2	Unknown	29681454	Open Targets	Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways HS-GAG biosynthesis +2 more
		EZH2	Unknown	29681454	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		FAM131B	Unknown	29681454	Open Targets	Signaling by BRAF and RAF fusions
		FAM135B	Unknown	29681454 33137577	Open Targets	—
		FAM47C	Unknown	29681454	Open Targets	—
		FANCE	Unknown	29681454	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCG	Unknown	29681454	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FBLN2	Unknown	29681454	Open Targets	Cytoskeleton in muscle cells Molecules associated with elastic fibres
		FBXO11	Unknown	29681454	Open Targets	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FBXW7	Unknown	25695693 26317919 31564914	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FCGR2B	Unknown	29681454	Open Targets	Virion - Ebolavirus, Lyssavirus and Morbillivirus Phagosome Osteoclast differentiation +6 more
		FGFR1	Unknown	16140923 28481359 29681454 33200540	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +32 more
		FGFR3	Unknown	16140923 23661334 29506987 29535832	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +27 more
		FIP1L1	Unknown	29681454 33137577	Open Targets	mRNA surveillance pathway Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway +4 more
		FKBP9	Unknown	29681454	Open Targets	—
		FLT3	Unknown	26317919 29681454	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		FLT4	Unknown	29681454	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		FOXL2	Unknown	28481359	Open Targets	SUMOylation of transcription factors
		FOXR1	Unknown	29681454	Open Targets	—
		GAS7	Unknown	29681454	Open Targets	—
		GATA2	Unknown	29681454	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GNAQ	Unknown	26124082	Open Targets	Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +52 more
		GNAS	Unknown	23856246 26124082 29681454 33200540	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		GOLGA5	Unknown	23033341 23856246 29681454	Open Targets	Intra-Golgi traffic
		GOPC	Unknown	22661537	Open Targets	RHO GTPases regulate CFTR trafficking
		GPC3	Unknown	29681454 33200540	Open Targets	Proteoglycans in cancer A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis +9 more
		GPHN	Unknown	29681454	Open Targets	Folate biosynthesis Metabolic pathways Biosynthesis of cofactors +2 more
		HERPUD1	Unknown	29681454	Open Targets	Protein processing in endoplasmic reticulum ATF4 activates genes in response to endoplasmic reticulum stress
		HGF	Unknown	26215952 29681454	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HIP1	Unknown	23856246 29681454	Open Targets	Huntington disease Pathways of neurodegeneration - multiple diseases Clathrin-mediated endocytosis
		HOXA13	Unknown	29681454	Open Targets	—
		HOXD13	Unknown	29681454	Open Targets	—
		IGF2BP2	Unknown	29681454	Open Targets	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
		IL7R	Unknown	29681454	Open Targets	Cytokine-cytokine receptor interaction FoxO signaling pathway PI3K-Akt signaling pathway +7 more
		JAK1	Unknown	29681454	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		KAT6B	Unknown	23856246 29681454 33200540	Open Targets	HATs acetylate histones
		KDM5A	Unknown	29681454 23856246 28481359	Open Targets	HDMs demethylate histones

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Anaplastic lung carcinoma

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