Subtype of: Lung cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
adenosquamous lung carcinoma	MONDO_0004973	DICER1	Unknown	29681454 28481359	Open Targets	MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
		DNMT3A	Unknown	23031157 28481359 29681454 33137577	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		EIF4A2	Unknown	28481359	Open Targets	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA +4 more
		ELF4	Unknown	33137577	Open Targets	—
		EP300	Unknown	10700188 28103823 28481359 29535832 29681454 33200540	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		FANCF	Unknown	29681454	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FAS	Unknown	29681454	Open Targets	Platinum drug resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +36 more
		FAT1	Unknown	29681454 28481359	Open Targets	—
		FAT3	Unknown	26215952 29681454	Open Targets	—
		FAT4	Unknown	23856246 26215952 29658848 29681454	Open Targets	Hippo signaling pathway - multiple species
		FCRL4	Unknown	29681454	Open Targets	—
		FLNA	Unknown	29658848 29681454	Open Targets	MAPK signaling pathway Focal adhesion Salmonella infection +6 more
		FOXP1	Unknown	28481359	Open Targets	MicroRNAs in cancer Transcriptional regulation of pluripotent stem cells
		FSTL3	Unknown	29681454	Open Targets	Antagonism of Activin by Follistatin Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
		GNA11	Unknown	29681454	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Hormone signaling +23 more
		IKBKB	Unknown	29681454 33200540	Open Targets	Antifolate resistance MAPK signaling pathway Ras signaling pathway +79 more
		IRS4	Unknown	29681454	Open Targets	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling +11 more
		KDM6A	Unknown	29681454	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KIF5B	Unknown	19383809 21225871 22327624 23150706 23951022 24481316 33200540	Open Targets	Endocytosis Dopaminergic synapse Motor proteins +12 more
		KMT2D	Unknown	26215952 28103823 28481359 29535832 29681454 33137577 33200540	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KNL1	Unknown	29681454	Open Targets	Cell cycle Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		KTN1	Unknown	29681454	Open Targets	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
		LARP4B	Unknown	29681454	Open Targets	—
		LCK	Unknown	29681454	Open Targets	NF-kappa B signaling pathway Osteoclast differentiation Natural killer cell mediated cytotoxicity +27 more
		LHFPL6	Unknown	29681454	Open Targets	—
		LRP1B	Unknown	25189529 26215952 29681454 33137577 33200540 36232538	Open Targets	—
		LSM14A	Unknown	29681454	Open Targets	—
		MAML2	Unknown	19269006	Open Targets	Notch signaling pathway Th1 and Th2 cell differentiation Human papillomavirus infection +9 more
		MAP3K13	Unknown	28481359	Open Targets	MAPK signaling pathway
		MECOM	Unknown	29681454	Open Targets	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
		MET	Unknown	16397241 24942490 26124082 26215952 26847053 27022036 28103823 28481359 28619094 29139039 29338938 29506987 29535832 29681454 30149144 30665873 31065835 31564914 32122695 32354937 32889305 33045465 33115932 33137577	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MLLT10	Unknown	29658848 33200540	Open Targets	—
		MLLT3	Unknown	29681454	Open Targets	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		MPL	Unknown	29681454	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		MSN	Unknown	29681454	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +4 more
		MTOR	Unknown	16140923 26215952 28481359 31534501 33200540	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MUC16	Unknown	26215952 29658848 29681454 33137577	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	29681454	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MYB	Unknown	29681454 33137577	Open Targets	PI3K-Akt signaling pathway RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression
		N4BP2	Unknown	29681454	Open Targets	—
		NCOA2	Unknown	29681454	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway RORA activates gene expression +14 more
		NCOR1	Unknown	29681454 33200540	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NOTCH1	Unknown	25969368 26215952 28481359 29535832 29681454	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	28103823 28481359 29535832 29681454 33200540	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NPM1	Unknown	18242762	Open Targets	Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere +2 more
		NTRK1	Unknown	25969368 29681454 33200540	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NUP98	Unknown	29681454	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		NUTM2B	Unknown	29681454	Open Targets	—
		PALB2	Unknown	29681454	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +3 more
		PCM1	Unknown	29681454	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more

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Adenosquamous lung carcinoma

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