Subtype of: Melanoma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
acral lentiginous melanoma	MONDO_0003865	ITK	Unknown	28467829	Open Targets	Chemokine signaling pathway T cell receptor signaling pathway Leukocyte transendothelial migration +2 more
		JAK1	Unknown	26359337	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK3	Unknown	22578220	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		KAT6A	Unknown	22578220 26359337	Open Targets	Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation
		KAT7	Unknown	26359337	Open Targets	HATs acetylate histones
		KDM5C	Unknown	26359337	Open Targets	HDMs demethylate histones
		KDM6A	Unknown	26359337	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KDR	Unknown	36219477 28467829	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KEAP1	Unknown	36219477 23938463	Open Targets	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KIT	Unknown	23014346 33024263 20545949 20372153 36219477 19812602 28467829 21356389 19718013 28421416 27771229 28373299 23993026 23775962 22261812 31043947 28870692 25363280 22464346 25695690 28356599 21569090 23528057 20088873 22513068 26359337 22437319 19802003 28944487	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KLF4	Unknown	26359337 28467829	Open Targets	Signaling pathways regulating pluripotency of stem cells Chemical carcinogenesis - receptor activation Synthesis, secretion, and deacylation of Ghrelin +1 more
		KLF6	Unknown	36219477	Open Targets	—
		KMT2A	Unknown	26359337	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	22578220 36219477 26359337	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	26359337 28467829 36219477	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KNSTRN	Unknown	36219477	Open Targets	—
		KRAS	Unknown	27771229 28373299 22437319 28467829	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		KTN1	Unknown	26359337	Open Targets	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
		LATS1	Unknown	26359337	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LATS2	Unknown	26359337	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LMNA	Unknown	26359337	Open Targets	Apoptosis Cytoskeleton in muscle cells Hypertrophic cardiomyopathy +8 more
		LOC100506403	Unknown	36219477	Open Targets	—
		LOC105376156	Unknown	36219477	Open Targets	—
		LRP1B	Unknown	22578220 26359337 28467829	Open Targets	—
		LSM14A	Unknown	26359337	Open Targets	—
		LZTR1	Unknown	28467829 28944487	Open Targets	—
		MACC1	Unknown	26359337	Open Targets	—
		MAF	Unknown	26359337	Open Targets	Th1 and Th2 cell differentiation Transcriptional misregulation in cancer Inflammatory bowel disease
		MAP2K1	Unknown	28467829	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more
		MAP2K2	Unknown	28467829 36219477	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +87 more
		MAP3K13	Unknown	22578220 28467829	Open Targets	MAPK signaling pathway
		MDM2	Unknown	36219477	Open Targets	Endocrine resistance Platinum drug resistance FoxO signaling pathway +35 more
		MDM4	Unknown	36219477	Open Targets	p53 signaling pathway MicroRNAs in cancer Oxidative Stress Induced Senescence +6 more
		MECOM	Unknown	36219477	Open Targets	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
		MED12	Unknown	22578220 26359337	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MEN1	Unknown	28467829	Open Targets	Cushing syndrome Transcriptional misregulation in cancer Formation of the beta-catenin:TCF transactivating complex +5 more
		MET	Unknown	22578220	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MITF	Unknown	36219477	Open Targets	Mitophagy - animal Osteoclast differentiation Melanogenesis +4 more
		MLLT10	Unknown	26359337	Open Targets	—
		MPL	Unknown	26359337 36219477	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		MSH2	Unknown	26359337 28467829	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MSH6	Unknown	26359337 28481359	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MSN	Unknown	26359337	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +4 more
		MTCP1	Unknown	26359337	Open Targets	PI3K-Akt signaling pathway
		MTOR	Unknown	26359337	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MUC16	Unknown	26359337 28467829	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	28467829	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUTYH	Unknown	26359337 28481359	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine +2 more
		MYC	Unknown	28467829	Open Targets	MAPK signaling pathway ErbB signaling pathway Cell cycle +45 more
		MYCL	Unknown	26359337	Open Targets	—

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Acral lentiginous melanoma

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