Subtype of: Melanoma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
acral lentiginous melanoma	MONDO_0003865	MYCN	Unknown	28467829	Open Targets	Transcriptional misregulation in cancer
		MYD88	Unknown	26359337	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Toll-like receptor signaling pathway +39 more
		MYH11	Unknown	22578220	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +6 more
		MYO5A	Unknown	22578220	Open Targets	Motor proteins Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation +1 more
		N4BP2	Unknown	26359337	Open Targets	—
		NACA	Unknown	26359337 28467829	Open Targets	Parathyroid hormone synthesis, secretion and action
		NBEA	Unknown	26359337	Open Targets	—
		NCOA1	Unknown	26359337	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway Pathways in cancer +18 more
		NF1	Unknown	22578220 36219477 26359337 28467829 28373299 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NF2	Unknown	28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Tight junction +2 more
		NFE2L2	Unknown	36219477 28481359	Open Targets	Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer +4 more
		NFIB	Unknown	28467829	Open Targets	—
		NFKB2	Unknown	28467829	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation +19 more
		NIN	Unknown	26359337	Open Targets	—
		NOTCH1	Unknown	26359337 28481359	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	26359337 28467829 36219477	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NR2F2	Unknown	28467829	Open Targets	—
		NRAS	Unknown	17535228 36219477 20544847 28467829 21356389 16098043 23739925 14961576 27771229 23362874 28373299 32654197 23993026 23775962 22261812 20720566 25767048 28870692 25363280 22404973 24458518 11886512 26359337 22437319 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NRG1	Unknown	28467829	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis +18 more
		NSD2	Unknown	26359337	Open Targets	Lysine degradation Metabolic pathways Transcriptional misregulation in cancer +5 more
		NT5C2	Unknown	28467829	Open Targets	Purine metabolism Pyrimidine metabolism Nicotinate and nicotinamide metabolism +4 more
		NTRK1	Unknown	26359337 36219477	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NTRK2	Unknown	36219477 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
		NTRK3	Unknown	28467829 28481359	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		NUMA1	Unknown	28467829	Open Targets	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
		NUP214	Unknown	26359337	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism +26 more
		NUP98	Unknown	36219477	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		NUTM1	Unknown	22578220 28467829 36219477	Open Targets	—
		PABPC1	Unknown	22578220	Open Targets	mRNA surveillance pathway RNA degradation L13a-mediated translational silencing of Ceruloplasmin expression +5 more
		PAX3	Unknown	28467829	Open Targets	Transcriptional misregulation in cancer HATs acetylate histones
		PBRM1	Unknown	22578220 28481359	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		PCM1	Unknown	26359337	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more
		PDGFRA	Unknown	36219477 28467829	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		PER1	Unknown	26359337	Open Targets	Circadian rhythm Circadian entrainment
		PHOX2B	Unknown	36219477 28467829	Open Targets	—
		PICALM	Unknown	28467829	Open Targets	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
		PIK3CA	Unknown	28870692 28481359	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3CB	Unknown	28481359	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +126 more
		PIK3R3	Unknown	26359337	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +116 more
		PLAG1	Unknown	28467829	Open Targets	—
		PLCG1	Unknown	26359337 36219477	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +70 more
		PLEC	Unknown	26359337	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PML	Unknown	26359337	Open Targets	Ubiquitin mediated proteolysis Endocytosis Influenza A +12 more
		PMS1	Unknown	28467829	Open Targets	—
		PMS2	Unknown	28481359	Open Targets	Mismatch repair Fanconi anemia pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) +3 more
		POLD1	Unknown	22578220 28467829	Open Targets	DNA replication Base excision repair Nucleotide excision repair +19 more
		POLE	Unknown	36219477 28481359 26359337	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		POLQ	Unknown	36219477 22578220 28467829 26359337	Open Targets	HDR through MMEJ (alt-NHEJ)
		POT1	Unknown	26359337 36219477	Open Targets	Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends +2 more
		PPFIBP1	Unknown	26359337 28467829	Open Targets	Receptor-type tyrosine-protein phosphatases

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Acral lentiginous melanoma

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