Subtype of: Lung cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
acinar lung adenocarcinoma	MONDO_0003892	AFF4	Unknown	27545006	Open Targets	Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events +1 more
		AKAP9	Unknown	27545006	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +7 more
		ALK	Unknown	20183914 24992725 27545006 25157770 24729716 24518094 30391211 23181703 21178715 23731739 22317764 25496960 18166835	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		AMER1	Unknown	27545006	Open Targets	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane +8 more
		AR	Unknown	27545006	Open Targets	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARHGAP26	Unknown	27545006	Open Targets	Rho GTPase cycle
		ATM	Unknown	27545006 24069199	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		BARD1	Unknown	27545006	Open Targets	Homologous recombination HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +11 more
		BCOR	Unknown	27545006	Open Targets	Polycomb repressive complex
		BCORL1	Unknown	27545006	Open Targets	Polycomb repressive complex
		BIRC6	Unknown	27545006	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		BRAF	Unknown	22317764 23131393	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA2	Unknown	27545006	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		CANT1	Unknown	31980561	Open Targets	Purine metabolism Pyrimidine metabolism Metabolic pathways +2 more
		CASP9	Unknown	27545006	Open Targets	Platinum drug resistance p53 signaling pathway PI3K-Akt signaling pathway +39 more
		CD74	Unknown	25157770 27545006 23877438	Open Targets	Antigen processing and presentation Tuberculosis Herpes simplex virus 1 infection +2 more
		CDC73	Unknown	27545006	Open Targets	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state +3 more
		CDK12	Unknown	27545006	Open Targets	TP53 Regulates Transcription of DNA Repair Genes
		CHD2	Unknown	27545006	Open Targets	—
		CHEK2	Unknown	27545006	Open Targets	Cell cycle p53 signaling pathway Cellular senescence +9 more
		CIC	Unknown	27545006	Open Targets	Spinocerebellar ataxia
		CLP1	Unknown	27545006	Open Targets	mRNA surveillance pathway tRNA processing in the nucleus mRNA Splicing - Major Pathway +3 more
		CLTC	Unknown	27545006	Open Targets	Lysosome Endocytosis Synaptic vesicle cycle +18 more
		CNBD1	Unknown	27545006	Open Targets	—
		CNTNAP2	Unknown	27545006	Open Targets	Cell adhesion molecules
		CSMD3	Unknown	27545006	Open Targets	—
		DAXX	Unknown	27545006	Open Targets	MAPK signaling pathway Apoptosis Parkinson disease +6 more
		DCTN1	Unknown	27545006	Open Targets	Motor proteins Vasopressin-regulated water reabsorption Amyotrophic lateral sclerosis +15 more
		DDR2	Unknown	27545006	Open Targets	Non-integrin membrane-ECM interactions
		EBF1	Unknown	27545006	Open Targets	—
		EGFR	Unknown	24992725 27545006 22733594 23486266 25176975 24828666 31980561 27013585 21178715 20975376 24722155 23937608 18261621 27133750 17601631 24729716 24457237 23468066 25120654 25496960 29074208 18208799 30391211 24636847 23181703 24300726 23731739 28677170	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		EIF3E	Unknown	27545006	Open Targets	Hepatitis C L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation +4 more
		ELF4	Unknown	27545006	Open Targets	—
		EML4	Unknown	20183914 24992725 25157770 24729716 23181703 21178715 23731739 22317764 25496960 18166835	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer +1 more
		EPHA3	Unknown	27545006	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		ERCC4	Unknown	27545006	Open Targets	Nucleotide excision repair Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +4 more
		EZH2	Unknown	27545006	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		FAM47C	Unknown	31980561	Open Targets	—
		FAT1	Unknown	27545006	Open Targets	—
		FAT3	Unknown	27545006	Open Targets	—
		FEN1	Unknown	27545006	Open Targets	DNA replication Base excision repair Non-homologous end-joining +6 more
		FGFR1	Unknown	27545006	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +32 more
		FGFR2	Unknown	27545006	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		FH	Unknown	27545006	Open Targets	Citrate cycle (TCA cycle) Pyruvate metabolism Metabolic pathways +5 more
		FHIT	Unknown	27545006	Open Targets	Purine metabolism Metabolic pathways Small cell lung cancer +1 more
		FLNA	Unknown	27545006	Open Targets	MAPK signaling pathway Focal adhesion Salmonella infection +6 more
		FUS	Unknown	27545006	Open Targets	mRNA surveillance pathway Spliceosome Amyotrophic lateral sclerosis +3 more
		GATA1	Unknown	27545006	Open Targets	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GPC5	Unknown	27545006	Open Targets	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation +7 more
		GRM3	Unknown	27545006	Open Targets	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more

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Acinar lung adenocarcinoma

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