HS3ST1 (heparan sulfate-glucosamine 3-sulfotransferase 1)

Gene

• Entrez ID: 9957
• Gene name: Heparan sulfate-glucosamine 3-sulfotransferase 1
• Gene symbol: HS3ST1
• Synonyms: 3OST, 3OST1
• Chromosome: 4
• Chromosome location: 4p15.33
• Summary: Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008]

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs16881446	T>C	Risk-factor	Intron variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT448217	hsa-miR-6885-3p	PAR-CLIP	22100165
MIRT448218	hsa-miR-1273e	PAR-CLIP	22100165
MIRT448219	hsa-miR-6126	PAR-CLIP	22100165
MIRT448220	hsa-miR-6864-5p	PAR-CLIP	22100165
MIRT448221	hsa-miR-1251-3p	PAR-CLIP	22100165
MIRT448222	hsa-miR-144-5p	PAR-CLIP	22100165
MIRT448223	hsa-miR-493-3p	PAR-CLIP	22100165
MIRT448224	hsa-miR-4635	PAR-CLIP	22100165
MIRT448225	hsa-miR-570-5p	PAR-CLIP	22100165
MIRT448226	hsa-miR-548ba	PAR-CLIP	22100165
MIRT448227	hsa-miR-548ai	PAR-CLIP	22100165
MIRT448228	hsa-miR-548ag	PAR-CLIP	22100165
MIRT448229	hsa-miR-4659b-3p	PAR-CLIP	22100165
MIRT448230	hsa-miR-6875-3p	PAR-CLIP	22100165
MIRT448231	hsa-miR-4659a-3p	PAR-CLIP	22100165
MIRT448232	hsa-miR-573	PAR-CLIP	22100165
MIRT448233	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT448234	hsa-miR-3182	PAR-CLIP	22100165
MIRT448235	hsa-miR-4766-5p	PAR-CLIP	22100165
MIRT448236	hsa-miR-3662	PAR-CLIP	22100165
MIRT545757	hsa-miR-6780a-3p	PAR-CLIP	21572407
MIRT545758	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT545759	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT545760	hsa-miR-4680-5p	PAR-CLIP	21572407
MIRT545761	hsa-miR-4539	PAR-CLIP	21572407
MIRT545762	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT545763	hsa-miR-4691-3p	PAR-CLIP	21572407
MIRT545764	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT545765	hsa-miR-4724-5p	PAR-CLIP	21572407
MIRT545766	hsa-miR-483-3p	PAR-CLIP	21572407
MIRT545767	hsa-miR-5582-3p	PAR-CLIP	21572407
MIRT545768	hsa-miR-508-5p	PAR-CLIP	21572407
MIRT545769	hsa-miR-548f-3p	PAR-CLIP	21572407
MIRT545770	hsa-miR-548e-3p	PAR-CLIP	21572407
MIRT545771	hsa-miR-548az-3p	PAR-CLIP	21572407
MIRT545772	hsa-miR-548ar-3p	PAR-CLIP	21572407
MIRT545773	hsa-miR-548a-3p	PAR-CLIP	21572407
MIRT616134	hsa-miR-7109-3p	HITS-CLIP	23824327
MIRT616135	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT616136	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT616137	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT616138	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT616138	hsa-miR-6744-3p	HITS-CLIP	23313552
MIRT616139	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT616139	hsa-miR-4757-5p	HITS-CLIP	23313552
MIRT616140	hsa-miR-4290	HITS-CLIP	23824327
MIRT616141	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT616142	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT616143	hsa-miR-1976	HITS-CLIP	23824327
MIRT616144	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT616145	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT616146	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT616147	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT616148	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT616149	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT623651	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT623652	hsa-miR-4276	HITS-CLIP	23824327
MIRT623653	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT623654	hsa-miR-5190	HITS-CLIP	23824327
MIRT623655	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT627132	hsa-miR-5698	HITS-CLIP	23824327
MIRT627133	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT627134	hsa-miR-4642	HITS-CLIP	23824327
MIRT627135	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT627136	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT627137	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT627138	hsa-miR-4430	HITS-CLIP	23824327
MIRT627139	hsa-miR-3652	HITS-CLIP	23824327
MIRT627140	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT627141	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT627142	hsa-miR-3135b	HITS-CLIP	23824327
MIRT627143	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT627144	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT627145	hsa-miR-1267	HITS-CLIP	23824327
MIRT627146	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT627147	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT627148	hsa-miR-6075	HITS-CLIP	23824327
MIRT627148	hsa-miR-6075	HITS-CLIP	19536157
MIRT627149	hsa-miR-5693	HITS-CLIP	23824327
MIRT638073	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT638074	hsa-miR-5691	HITS-CLIP	23824327
MIRT638075	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT686141	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT686142	hsa-miR-6878-3p	HITS-CLIP	23313552
MIRT686143	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT686144	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT686145	hsa-miR-5095	HITS-CLIP	23313552
MIRT686146	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT686147	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT686148	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT686149	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT686150	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT686151	hsa-miR-520h	HITS-CLIP	23313552
MIRT686152	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT686153	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT686154	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT686155	hsa-miR-4438	HITS-CLIP	23313552
MIRT686156	hsa-miR-520e	HITS-CLIP	23313552
MIRT686157	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT686158	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT686159	hsa-miR-520b	HITS-CLIP	23313552
MIRT686160	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT686161	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT686162	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT686163	hsa-miR-302e	HITS-CLIP	23313552
MIRT686164	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT686165	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT686166	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT686167	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT686168	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT686169	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT686170	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT686171	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT686172	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT686173	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT686174	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT686175	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT702800	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT702801	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT702802	hsa-miR-941	HITS-CLIP	23313552
MIRT715336	hsa-miR-4313	HITS-CLIP	19536157
MIRT715337	hsa-miR-4772-3p	HITS-CLIP	19536157
MIRT715338	hsa-miR-6810-3p	HITS-CLIP	19536157
MIRT715339	hsa-miR-6801-3p	HITS-CLIP	19536157

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005796	Component	Golgi lumen	TAS
GO:0006024	Process	Glycosaminoglycan biosynthetic process	TAS
GO:0008146	Function	Sulfotransferase activity	TAS	9988767
GO:0008467	Function	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IBA	21873635

Other IDs

• MIM: 603244
• HGNC: 5194
• e!Ensembl: ENSG00000002587

Protein

• UniProt ID: O14792
• Protein name: Heparan sulfate glucosamine 3-O-sulfotransferase 1 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1) (3-OST-1) (Heparan sulfate 3-O-sulfotransferase 1) (h3-OST-1)
• Protein function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.
• PDB: 1ZRH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00685	Sulfotransfer_1	54 → 298	Sulfotransferase domain	Domain

• Sequence:

  MAALLLGAVLLVAQPQLVPSRPAELGQQELLRKAGTLQDDVRDGVAPNGSAQQLPQTIII
  GVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYSHGLGWYLSQMPFSWPHQLTVEKT
  PAYFTSPKVPERVYSMNPSIRLLLILRDPSERVLSDYTQVFYNHMQKHKPYPSIEEFLVR
  DGRLNVDYKALNRSLYHVHMQNWLRFFPLRHIHIVDGDRLIRDPFPEIQKVERFLKLSPQ
  INASNFYFNKTKGFYCLRDSGRDRCLHESKGRAHPQVDPKLLNKLHEYFHEPNKKFFELV
  GRTFDWH

• Sequence length: 307

Pathways

KEGG:

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

Reactome:

HS-GAG biosynthesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	15266341

Unknown
Disease name	Disease term	dbSNP ID	References
Arteriosclerosis	Arteriosclerosis		15266341