HS3ST4 (heparan sulfate-glucosamine 3-sulfotransferase 4)

Gene

• Entrez ID: 9951
• Gene name: Heparan sulfate-glucosamine 3-sulfotransferase 4
• Gene symbol: HS3ST4
• Synonyms: 3-OST-4, 30ST4, 3OST4, h3-OST-4
• Chromosome: 16
• Chromosome location: 16p12.1
• Summary: This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus type 1 (HSV-1), and

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1054958	hsa-miR-1293	CLIP-seq
MIRT1054959	hsa-miR-147	CLIP-seq
MIRT1054960	hsa-miR-298	CLIP-seq
MIRT1054961	hsa-miR-302a	CLIP-seq
MIRT1054962	hsa-miR-302b	CLIP-seq
MIRT1054963	hsa-miR-302c	CLIP-seq
MIRT1054964	hsa-miR-302d	CLIP-seq
MIRT1054965	hsa-miR-302e	CLIP-seq
MIRT1054966	hsa-miR-3152-5p	CLIP-seq
MIRT1054967	hsa-miR-3650	CLIP-seq
MIRT1054968	hsa-miR-372	CLIP-seq
MIRT1054969	hsa-miR-373	CLIP-seq
MIRT1054970	hsa-miR-3911	CLIP-seq
MIRT1054971	hsa-miR-4455	CLIP-seq
MIRT1054972	hsa-miR-4483	CLIP-seq
MIRT1054973	hsa-miR-4677-3p	CLIP-seq
MIRT1054974	hsa-miR-4679	CLIP-seq
MIRT1054975	hsa-miR-4774-3p	CLIP-seq
MIRT1054976	hsa-miR-520a-3p	CLIP-seq
MIRT1054977	hsa-miR-520b	CLIP-seq
MIRT1054978	hsa-miR-520c-3p	CLIP-seq
MIRT1054979	hsa-miR-520d-3p	CLIP-seq
MIRT1054980	hsa-miR-520e	CLIP-seq
MIRT1054981	hsa-miR-520f	CLIP-seq
MIRT1054982	hsa-miR-609	CLIP-seq
MIRT1054983	hsa-miR-644	CLIP-seq
MIRT2012495	hsa-miR-1289	CLIP-seq
MIRT2012496	hsa-miR-3157-5p	CLIP-seq
MIRT2012497	hsa-miR-3690	CLIP-seq
MIRT2012498	hsa-miR-4254	CLIP-seq
MIRT2012499	hsa-miR-4691-3p	CLIP-seq
MIRT2012500	hsa-miR-512-5p	CLIP-seq
MIRT2012495	hsa-miR-1289	CLIP-seq
MIRT2437641	hsa-miR-3160-5p	CLIP-seq
MIRT2437642	hsa-miR-3198	CLIP-seq
MIRT2437643	hsa-miR-4294	CLIP-seq
MIRT2437644	hsa-miR-4309	CLIP-seq
MIRT2012495	hsa-miR-1289	CLIP-seq
MIRT2437641	hsa-miR-3160-5p	CLIP-seq
MIRT2437642	hsa-miR-3198	CLIP-seq
MIRT2437643	hsa-miR-4294	CLIP-seq
MIRT2437644	hsa-miR-4309	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0008467	Function	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IBA	21873635
GO:0008467	Function	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	NAS	9988767
GO:0016021	Component	Integral component of membrane	IEA
GO:0030201	Process	Heparan sulfate proteoglycan metabolic process	NAS	9988767

Other IDs

• MIM: 604059
• HGNC: 5200
• e!Ensembl: ENSG00000182601

Protein

• UniProt ID: Q9Y661
• Protein name: Heparan sulfate glucosamine 3-O-sulfotransferase 4 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4) (3-OST-4) (Heparan sulfate 3-O-sulfotransferase 4) (h3-OST-4)
• Protein function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-an
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00685	Sulfotransfer_1	197 → 446	Sulfotransferase domain	Domain

• Sequence:

  MARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQ
  FPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAA
  PGTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALPEREAQESSTTDEDLAGRRAANGS
  SERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDRNYEKG
  LEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQ
  TLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILFVSGERL
  IVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRI
  DPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGDK

• Sequence length: 456

Pathways

Reactome:

HS-GAG biosynthesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959
Lymphoblastic leukemia	Precursor Cell Lymphoblastic Leukemia Lymphoma	rs387906351, rs104894562, rs398122513, rs398122840, rs398123063, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699, rs1597567692, rs1597567985, rs1438890364, rs1288977950, rs1597552140, rs1597566356, rs1597566726, rs1597568117, rs2069719445, rs2069729948, rs2070018439, rs745708044, rs1169577591	30450575
Age-related macular degeneration	Age related macular degeneration	rs2133900556, rs199474657, rs2274700, rs1410996, rs61750120, rs1800728, rs62654397, rs61749423, rs61751412, rs61749439, rs61751398, rs61752417, rs62645946, rs1801269, rs62646860, rs61750142, rs61750145, rs61750152, rs61751377, rs61753029, rs61751407, rs61751389, rs61750645, rs61750648, rs879255520, rs752147871, rs886044750, rs886044749, rs746541266, rs756840095, rs886044725, rs749526785, rs1057518955, rs1057518767, rs371489809, rs1064793014, rs1571264574, rs1659524475	29346644