Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
9943 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Oxidative stress responsive kinase 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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OXSR1 |
SynonymsGene synonyms aliases
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OSR1 |
ChromosomeChromosome number
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3 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
3p22.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
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The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008] |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
O95747 |
Protein name |
Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) |
Protein function |
Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:213 |
PDB |
2V3S
,
2VWI
,
3DAK
,
7OKW
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00069 |
Pkinase |
17 → 291 |
Protein kinase domain |
Domain |
PF12202 |
OSR1_C |
434 → 491 |
Oxidative-stress-responsive kinase 1 C-terminal domain |
Domain |
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Sequence |
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Sequence length |
527 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Hypertension |
Hypertensive disease |
rs13306026, rs13333226 |
22949526 |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
20819979 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Metastatic melanoma |
Metastatic melanoma |
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