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OXSR1 (oxidative stress responsive kinase 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9943
Gene nameGene Name - the full gene name approved by the HGNC.
Oxidative stress responsive kinase 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
OXSR1
SynonymsGene synonyms aliases
OSR1
ChromosomeChromosome number
3
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p22.2
SummarySummary of gene provided in NCBI Entrez Gene.
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT029769 hsa-miR-26b-5p Microarray 19088304
MIRT030472 hsa-miR-24-3p Microarray 19748357
MIRT043941 hsa-miR-378a-3p CLASH 23622248
MIRT655571 hsa-miR-7113-5p HITS-CLIP 23824327
MIRT655572 hsa-miR-4685-5p HITS-CLIP 23824327
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IDA 14707132
GO:0004674 Function Protein serine/threonine kinase activity IDA 14707132, 24393035
GO:0004674 Function Protein serine/threonine kinase activity IMP 16669787
GO:0005515 Function Protein binding IPI 16669787, 16832045, 17721439, 21423148, 24393035, 25416956, 28514442, 32296183
GO:0005524 Function ATP binding IDA 14707132
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O95747
Protein name Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein)
Protein function Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:213
PDB 2V3S , 2VWI , 3DAK , 7OKW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase
17 291
Protein kinase domain
Domain
PF12202 OSR1_C
434 491
Oxidative-stress-responsive kinase 1 C-terminal domain
Domain
Sequence
Sequence length 527
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
  Parathyroid hormone synthesis, secretion and action  
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Hypertension Hypertensive disease rs13306026, rs13333226 22949526
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 20819979
Unknown
Disease name Disease term dbSNP ID References
Metastatic melanoma Metastatic melanoma

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