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CDC20 (cell division cycle 20)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
991
Gene nameGene Name - the full gene name approved by the HGNC.
Cell division cycle 20
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CDC20
SynonymsGene synonyms aliases
CDC20A, OOMD14, OZEMA14, bA276H19.3, p55CDC
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p34.2
SummarySummary of gene provided in NCBI Entrez Gene.
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016385 hsa-miR-193b-3p Microarray 20304954
MIRT024643 hsa-miR-215-5p Microarray 19074876
MIRT025414 hsa-miR-34a-5p Proteomics 21566225
MIRT026319 hsa-miR-192-5p Microarray 19074876
MIRT028518 hsa-miR-30a-5p Proteomics 18668040
Transcription factors
Transcription factor Regulation Reference
PHF8 Unknown 23979597
YBX1 Repression 20596676
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000922 Component Spindle pole IEA
GO:0005515 Function Protein binding IPI 11030144, 11459826, 11988738, 14743218, 15182668, 15525512, 16525508, 17443180, 17443186, 17719540, 18022367, 18318601, 18794143, 19143472, 19282672, 19407811, 20212161, 20360068, 20951947, 21041666, 21300909, 21407176, 21725316, 21772247, 22000412, 22014574, 22322943, 22340593, 232
GO:0005654 Component Nucleoplasm IDA
GO:0005654 Component Nucleoplasm TAS
GO:0005680 Component Anaphase-promoting complex IDA 11459825
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q12834
Protein name Cell division cycle protein 20 homolog (p55CDC)
Protein function Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed
PDB 4GGA , 4GGC , 4GGD , 4N14 , 5G04 , 5KHR , 5KHU , 5LCW , 6F0X , 6Q6G , 6Q6H , 9I68 , 9I69 , 9I6A
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12894 ANAPC4_WD40
218 279
Anaphase-promoting complex subunit 4 WD40 domain
Repeat
PF00400 WD40
299 336
WD domain, G-beta repeat
Repeat
PF00400 WD40
345 386
WD domain, G-beta repeat
Repeat
PF00400 WD40
390 429
WD domain, G-beta repeat
Repeat
PF00400 WD40
433 471
WD domain, G-beta repeat
Repeat
Sequence
MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTP
GKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNL
NGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPE
IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY
LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY
ILSSGSRSGHIHHHDVRVAEH
HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW
PSAPGEGGWVPLQTFTQHQGAVKA
VAWCPWQSNVLATGGGTSDRHIRIWN
VCSGACLSAVDAHSQVCSILWSPHYKELISGHGF
AQNQLVIWK
YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR
REREKASAAKSSLIHQGIR
Sequence length 499
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Cell cycle
Oocyte meiosis
Ubiquitin mediated proteolysis
Human T-cell leukemia virus 1 infection
Viral carcinogenesis
  Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
APC/C:Cdc20 mediated degradation of Cyclin B
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of Emi1
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Ub-specific processing proteases
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Lymphoblastic leukemia Precursor Cell Lymphoblastic Leukemia Lymphoma rs387906351, rs104894562, rs398122513, rs398122840, rs398123063, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699, rs1597567692, rs1597567985, rs1438890364, rs1288977950, rs1597552140, rs1597566356, rs1597566726, rs1597568117, rs2069719445, rs2069729948, rs2070018439, rs745708044, rs1169577591 27114598
Unknown
Disease name Disease term dbSNP ID References
Liver carcinoma Liver carcinoma 28284560

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