Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
991 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Cell division cycle 20 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
CDC20 |
SynonymsGene synonyms aliases
|
CDC20A, OOMD14, OZEMA14, bA276H19.3, p55CDC |
ChromosomeChromosome number
|
1 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
1p34.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by |
miRNAmiRNA information provided by mirtarbase database.
|
|
Transcription factors
|
Transcription factor |
Regulation |
Reference |
PHF8 |
Unknown |
23979597 |
YBX1 |
Repression |
20596676 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000922 |
Component |
Spindle pole |
IEA |
|
GO:0005515 |
Function |
Protein binding |
IPI |
11030144, 11459826, 11988738, 14743218, 15182668, 15525512, 16525508, 17443180, 17443186, 17719540, 18022367, 18318601, 18794143, 19143472, 19282672, 19407811, 20212161, 20360068, 20951947, 21041666, 21300909, 21407176, 21725316, 21772247, 22000412, 22014574, 22322943, 22340593, 232 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005680 |
Component |
Anaphase-promoting complex |
IDA |
11459825 |
GO:0005813 |
Component |
Centrosome |
IEA |
|
GO:0005819 |
Component |
Spindle |
TAS |
7513050 |
GO:0005829 |
Component |
Cytosol |
IDA |
|
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0006511 |
Process |
Ubiquitin-dependent protein catabolic process |
TAS |
|
GO:0007064 |
Process |
Mitotic sister chromatid cohesion |
IEA |
|
GO:0007094 |
Process |
Mitotic spindle assembly checkpoint |
TAS |
|
GO:0007399 |
Process |
Nervous system development |
IEA |
|
GO:0008022 |
Function |
Protein C-terminus binding |
IPI |
10700282 |
GO:0008284 |
Process |
Positive regulation of cell population proliferation |
IEA |
|
GO:0010997 |
Function |
Anaphase-promoting complex binding |
IBA |
21873635 |
GO:0016567 |
Process |
Protein ubiquitination |
IEA |
|
GO:0016579 |
Process |
Protein deubiquitination |
TAS |
|
GO:0019899 |
Function |
Enzyme binding |
IPI |
17443180 |
GO:0030154 |
Process |
Cell differentiation |
IEA |
|
GO:0031145 |
Process |
Anaphase-promoting complex-dependent catabolic process |
IBA |
21873635 |
GO:0031145 |
Process |
Anaphase-promoting complex-dependent catabolic process |
IDA |
17443180 |
GO:0031145 |
Process |
Anaphase-promoting complex-dependent catabolic process |
TAS |
|
GO:0031915 |
Process |
Positive regulation of synaptic plasticity |
ISS |
|
GO:0040020 |
Process |
Regulation of meiotic nuclear division |
IEA |
|
GO:0042826 |
Function |
Histone deacetylase binding |
IEA |
|
GO:0048471 |
Component |
Perinuclear region of cytoplasm |
IEA |
|
GO:0050773 |
Process |
Regulation of dendrite development |
IEA |
|
GO:0051301 |
Process |
Cell division |
IEA |
|
GO:0090129 |
Process |
Positive regulation of synapse maturation |
ISS |
|
GO:0090307 |
Process |
Mitotic spindle assembly |
IEA |
|
GO:1901990 |
Process |
Regulation of mitotic cell cycle phase transition |
TAS |
|
GO:1904668 |
Process |
Positive regulation of ubiquitin protein ligase activity |
IDA |
11459826 |
GO:1905786 |
Process |
Positive regulation of anaphase-promoting complex-dependent catabolic process |
IBA |
21873635 |
GO:1990757 |
Function |
Ubiquitin ligase activator activity |
IBA |
21873635 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
Q12834 |
Protein name |
Cell division cycle protein 20 homolog (p55CDC) |
Protein function |
Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed |
PDB |
4GGA
,
4GGC
,
4GGD
,
4N14
,
5G04
,
5KHR
,
5KHU
,
5LCW
,
6F0X
,
6Q6G
,
6Q6H
,
9I68
,
9I69
,
9I6A
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF12894 |
ANAPC4_WD40 |
218 → 279 |
Anaphase-promoting complex subunit 4 WD40 domain |
Repeat |
PF00400 |
WD40 |
299 → 336 |
WD domain, G-beta repeat |
Repeat |
PF00400 |
WD40 |
345 → 386 |
WD domain, G-beta repeat |
Repeat |
PF00400 |
WD40 |
390 → 429 |
WD domain, G-beta repeat |
Repeat |
PF00400 |
WD40 |
433 → 471 |
WD domain, G-beta repeat |
Repeat |
|
Sequence |
|
Sequence length |
499 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
|
|
Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Lymphoblastic leukemia |
Precursor Cell Lymphoblastic Leukemia Lymphoma |
rs387906351, rs104894562, rs398122513, rs398122840, rs398123063, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699, rs1597567692, rs1597567985, rs1438890364, rs1288977950, rs1597552140, rs1597566356, rs1597566726, rs1597568117, rs2069719445, rs2069729948, rs2070018439, rs745708044, rs1169577591 |
27114598 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Liver carcinoma |
Liver carcinoma |
|
28284560 |
|