RHOBTB1 (Rho related BTB domain containing 1)

Gene

• Entrez ID: 9886
• Gene name: Rho related BTB domain containing 1
• Gene symbol: RHOBTB1
• Synonyms: -
• Chromosome: 10
• Chromosome location: 10q21.2
• Summary: The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The p

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018495	hsa-miR-335-5p	Microarray	18185580
MIRT050128	hsa-miR-26a-5p	CLASH	23622248
MIRT437512	hsa-miR-31-5p	Luciferase reporter assay	23258531
MIRT437512	hsa-miR-31-5p	Luciferase reporter assay	23258531
MIRT1305401	hsa-miR-1244	CLIP-seq
MIRT1305402	hsa-miR-1271	CLIP-seq
MIRT1305403	hsa-miR-1297	CLIP-seq
MIRT1305404	hsa-miR-182	CLIP-seq
MIRT1305405	hsa-miR-1910	CLIP-seq
MIRT1305406	hsa-miR-26a	CLIP-seq
MIRT1305407	hsa-miR-26b	CLIP-seq
MIRT1305408	hsa-miR-31	CLIP-seq
MIRT1305409	hsa-miR-3122	CLIP-seq
MIRT1305410	hsa-miR-3165	CLIP-seq
MIRT1305411	hsa-miR-3185	CLIP-seq
MIRT1305412	hsa-miR-3689a-3p	CLIP-seq
MIRT1305413	hsa-miR-3689c	CLIP-seq
MIRT1305414	hsa-miR-383	CLIP-seq
MIRT1305415	hsa-miR-3913-5p	CLIP-seq
MIRT1305416	hsa-miR-4276	CLIP-seq
MIRT1305417	hsa-miR-4325	CLIP-seq
MIRT1305418	hsa-miR-4465	CLIP-seq
MIRT1305419	hsa-miR-4473	CLIP-seq
MIRT1305420	hsa-miR-4528	CLIP-seq
MIRT1305421	hsa-miR-455-3p	CLIP-seq
MIRT1305422	hsa-miR-4652-3p	CLIP-seq
MIRT1305423	hsa-miR-4697-3p	CLIP-seq
MIRT1305424	hsa-miR-4729	CLIP-seq
MIRT1305425	hsa-miR-4789-5p	CLIP-seq
MIRT1305426	hsa-miR-4796-3p	CLIP-seq
MIRT1305427	hsa-miR-507	CLIP-seq
MIRT1305428	hsa-miR-509-3p	CLIP-seq
MIRT1305429	hsa-miR-512-3p	CLIP-seq
MIRT1305430	hsa-miR-520f	CLIP-seq
MIRT1305431	hsa-miR-548t	CLIP-seq
MIRT1305432	hsa-miR-557	CLIP-seq
MIRT1305433	hsa-miR-579	CLIP-seq
MIRT1305434	hsa-miR-590-3p	CLIP-seq
MIRT1305435	hsa-miR-885-5p	CLIP-seq
MIRT1305436	hsa-miR-96	CLIP-seq
MIRT1305410	hsa-miR-3165	CLIP-seq
MIRT1305414	hsa-miR-383	CLIP-seq
MIRT1305426	hsa-miR-4796-3p	CLIP-seq
MIRT1305430	hsa-miR-520f	CLIP-seq
MIRT1305431	hsa-miR-548t	CLIP-seq
MIRT2090367	hsa-miR-204	CLIP-seq
MIRT2090368	hsa-miR-211	CLIP-seq
MIRT2090369	hsa-miR-4419a	CLIP-seq
MIRT2090370	hsa-miR-4510	CLIP-seq
MIRT2090371	hsa-miR-4693-3p	CLIP-seq
MIRT2315228	hsa-miR-1226	CLIP-seq
MIRT2315229	hsa-miR-1261	CLIP-seq
MIRT2315230	hsa-miR-146b-3p	CLIP-seq
MIRT2315231	hsa-miR-155	CLIP-seq
MIRT2315232	hsa-miR-299-3p	CLIP-seq
MIRT2315233	hsa-miR-3123	CLIP-seq
MIRT2315234	hsa-miR-3157-3p	CLIP-seq
MIRT2315235	hsa-miR-3173-5p	CLIP-seq
MIRT2315236	hsa-miR-3174	CLIP-seq
MIRT2315237	hsa-miR-3646	CLIP-seq
MIRT2315238	hsa-miR-3682-5p	CLIP-seq
MIRT2315239	hsa-miR-4265	CLIP-seq
MIRT2315240	hsa-miR-4296	CLIP-seq
MIRT2315241	hsa-miR-4308	CLIP-seq
MIRT2315242	hsa-miR-4310	CLIP-seq
MIRT2315243	hsa-miR-4311	CLIP-seq
MIRT2315244	hsa-miR-4322	CLIP-seq
MIRT2315245	hsa-miR-4417	CLIP-seq
MIRT2315246	hsa-miR-4484	CLIP-seq
MIRT2315247	hsa-miR-4704-5p	CLIP-seq
MIRT2315248	hsa-miR-4731-5p	CLIP-seq
MIRT2315249	hsa-miR-4738-5p	CLIP-seq
MIRT2315250	hsa-miR-4753-5p	CLIP-seq
MIRT2315251	hsa-miR-513a-5p	CLIP-seq
MIRT2315252	hsa-miR-548an	CLIP-seq
MIRT2315253	hsa-miR-570	CLIP-seq
MIRT2315254	hsa-miR-630	CLIP-seq
MIRT2315255	hsa-miR-874	CLIP-seq
MIRT2315251	hsa-miR-513a-5p	CLIP-seq
MIRT2432723	hsa-miR-141	CLIP-seq
MIRT2432724	hsa-miR-200a	CLIP-seq
MIRT2432725	hsa-miR-384	CLIP-seq
MIRT2315253	hsa-miR-570	CLIP-seq
MIRT2611526	hsa-miR-1207-5p	CLIP-seq
MIRT2611527	hsa-miR-203	CLIP-seq
MIRT2611528	hsa-miR-297	CLIP-seq
MIRT2611529	hsa-miR-3064-3p	CLIP-seq
MIRT2611530	hsa-miR-3143	CLIP-seq
MIRT2611531	hsa-miR-331-3p	CLIP-seq
MIRT2611532	hsa-miR-3665	CLIP-seq
MIRT2611533	hsa-miR-370	CLIP-seq
MIRT2432725	hsa-miR-384	CLIP-seq
MIRT2611534	hsa-miR-3911	CLIP-seq
MIRT2611535	hsa-miR-3934	CLIP-seq
MIRT2611536	hsa-miR-4633-3p	CLIP-seq
MIRT2611537	hsa-miR-4736	CLIP-seq
MIRT2611538	hsa-miR-4763-3p	CLIP-seq
MIRT2611539	hsa-miR-567	CLIP-seq
MIRT2611540	hsa-miR-626	CLIP-seq
MIRT2611541	hsa-miR-663b	CLIP-seq
MIRT2689748	hsa-miR-548c-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005525	Function	GTP binding	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IBA	21873635
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0005938	Component	Cell cortex	IBA	21873635
GO:0007015	Process	Actin filament organization	IBA	21873635
GO:0007163	Process	Establishment or maintenance of cell polarity	IBA	21873635
GO:0007264	Process	Small GTPase mediated signal transduction	IEA
GO:0008360	Process	Regulation of cell shape	IBA	21873635
GO:0019901	Function	Protein kinase binding	IBA	21873635
GO:0030865	Process	Cortical cytoskeleton organization	IBA	21873635
GO:0031410	Component	Cytoplasmic vesicle	IBA	21873635
GO:0032956	Process	Regulation of actin cytoskeleton organization	IBA	21873635
GO:0042995	Component	Cell projection	IBA	21873635
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA	21873635
GO:0043652	Process	Engulfment of apoptotic cell	IBA	21873635
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

Other IDs

• MIM: 607351
• HGNC: 18738
• e!Ensembl: ENSG00000072422

Protein

• UniProt ID: O94844
• Protein name: Rho-related BTB domain-containing protein 1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00071	Ras	16 → 209	Ras family	Domain
  PF00651	BTB	384 → 457	BTB/POZ domain	Domain
  PF00651	BTB	475 → 583	BTB/POZ domain	Domain

• Sequence:

  MDADMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYR
  VCQEVLERSRDVVDEVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKS
  MWYPEIKHFCPRTPVILVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKE
  LGLPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPP
  PVIKIPECPSMGTNEAACLLDNPLCADVLFILQDQEHIFAHRIYLATSSSKFYDLFLMEC
  EESPNGSEGACEKEKQSRDFQGRILSVDPEEEREEGPPRIPQADQWKSSNKSLVEALGLE
  AEGAVPETQTLTGWSKGFIGMHREMQVNPISKRMGPMTVVRMDASVQPGPFRTLLQFLYT
  GQLDEKEKDLVGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLS
  KGTFSDVTFKLDDGAISAHKPLLICSCEWMAAMFGGSFVESANSEVYLPNINKISMQAVL
  DYLYTKQLSPNLDLDPLELIALANRFCLPHLVALAEQHAVQELTKAATSGVGIDGEVLSY
  LELAQFHNAHQLAAWCLHHICTNYNSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEE
  DHYQRVKREREKEDIALNKHRSRRKWCFWNSSPAVA

• Sequence length: 696

Pathways

KEGG:

Ubiquitin mediated proteolysis

Reactome:

Rho GTPase cycle

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Arthritis	Juvenile arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	19565504
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	28736931

Unknown
Disease name	Disease term	dbSNP ID	References
Juvenile arthritis	Juvenile psoriatic arthritis		19565504
Seronegative polyarthritis	Polyarthritis, Juvenile, Rheumatoid Factor Negative		19565504
Polyarthritis, rheumatoid factor positive	Polyarthritis, Juvenile, Rheumatoid Factor Positive		19565504
Still disease	Juvenile-Onset Still Disease		19565504