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LRIG2 (leucine rich repeats and immunoglobulin like domains 2)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9860
Gene nameGene Name - the full gene name approved by the HGNC.
Leucine rich repeats and immunoglobulin like domains 2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
LRIG2
SynonymsGene synonyms aliases
LIG-2, LIG2, UFS2
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p13.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cel
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs587776945 A>- Pathogenic Coding sequence variant, frameshift variant, genic upstream transcript variant, 5 prime UTR variant
rs587776946 C>T Pathogenic Stop gained, coding sequence variant
rs587776947 C>- Pathogenic Coding sequence variant, frameshift variant
rs1399525051 G>T Likely-pathogenic Coding sequence variant, genic upstream transcript variant, 5 prime UTR variant, stop gained
rs1557914199 C>A Likely-pathogenic Intron variant, coding sequence variant, missense variant
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT725402 hsa-miR-3200-5p HITS-CLIP 19536157
MIRT725401 hsa-miR-16-2-3p HITS-CLIP 19536157
MIRT725400 hsa-miR-195-3p HITS-CLIP 19536157
MIRT725398 hsa-miR-4251 HITS-CLIP 19536157
MIRT725399 hsa-miR-4329 HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
FOS Unknown 22721266
TAF1 Unknown 22721266
YY1 Unknown 22721266
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005102 Function Signaling receptor binding IEA
GO:0005515 Function Protein binding IPI 25353163, 30015847
GO:0005615 Component Extracellular space IBA 21873635
GO:0005737 Component Cytoplasm IEA
GO:0005886 Component Plasma membrane IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O94898
Protein name Leucine-rich repeats and immunoglobulin-like domains protein 2 (LIG-2)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13855 LRR_8
144 194
Leucine rich repeat
Repeat
PF13855 LRR_8
240 299
Leucine rich repeat
Repeat
PF13855 LRR_8
289 347
Leucine rich repeat
Repeat
PF13855 LRR_8
311 371
Leucine rich repeat
Repeat
PF13855 LRR_8
335 398
Leucine rich repeat
Repeat
PF01463 LRRCT
468 493
Leucine rich repeat C-terminal domain
Family
PF13927 Ig_3
497 584
Domain
PF07679 I-set
602 692
Immunoglobulin I-set domain
Domain
PF07679 I-set
696 783
Immunoglobulin I-set domain
Domain
Sequence
MAPAPLGVPEEQLLGCRSRVLSRLLFIAQTALLLLPAAGAGLCPAPCSCRIPLLDCSRRK
LPAPSWRALSGLLPPDTAILDFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTS
NITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRIT
TLEAGCFDNLSSSL
LVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDS
LRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRM
LQQLYVSQNAIE
RISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSN
LQTLDLRNNEI
SWAIEDASEAFAGLTSLTKLILQGNQI
KSITKKAFIGLESLEHLDLNNN
AIMSIQENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQ
SILNVDLKDFVCD
DFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEIL
YDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTN
HFGSNYSQKAKLTVNE
MPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVF
FIANVKIEDMGIYSCMAQNTAGGLSANASLTV
LETPSFIRPLEDKTVTRGETAVLQCIAG
GSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIY
LNV
ISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSI
TNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSHQQLMPPANGYIHKGTDGGTGTRV
ICSDCYDNANIYSRTREYCPYTYIAEEDVLDQTLSSLMVQMPKETYLVHPPQDTTALESL
IPSANREPSAFPTNHERISEKKLPSTQMSGETLQRPVWNINRELGLPHPPFSQQPVHESP
QLHQNEGLAGREPDCSASSMSCHRLQDHAFDFSRTRNIQDGSEGT
Sequence length 1065
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
  Axon guidance  
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Cryptorchidism Cryptorchidism rs121912555, rs104894697, rs104894698, rs398122886
Hypertension Hypertensive disease rs13306026, rs13333226
Renal insufficiency Renal Insufficiency rs1596536873
Urofacial syndrome UROFACIAL SYNDROME 2 rs267606866, rs397515338, rs1469962264, rs267606864, rs267606865, rs778121647, rs587776945, rs587776946, rs587776947, rs397515452, rs1570764426
Unknown
Disease name Disease term dbSNP ID References
Bowel incontinence Fecal Incontinence
Hydronephrosis Hydronephrosis
Ochoa syndrome Ochoa syndrome 23313374
Urethral obstruction Urethral Obstruction

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