FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2)

Gene

• Entrez ID: 9855
• Gene name: FERM, ARH/RhoGEF and pleckstrin domain protein 2
• Gene symbol: FARP2
• Synonyms: FIR, FRG, PLEKHC3
• Chromosome: 2
• Chromosome location: 2q37.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT989450	hsa-miR-1225-5p	CLIP-seq
MIRT989451	hsa-miR-3150a-3p	CLIP-seq
MIRT989452	hsa-miR-3175	CLIP-seq
MIRT989453	hsa-miR-34a	CLIP-seq
MIRT989454	hsa-miR-34c-5p	CLIP-seq
MIRT989455	hsa-miR-449a	CLIP-seq
MIRT989456	hsa-miR-449b	CLIP-seq
MIRT989457	hsa-miR-4708-5p	CLIP-seq
MIRT989458	hsa-miR-939	CLIP-seq
MIRT1993225	hsa-miR-1827	CLIP-seq
MIRT1993226	hsa-miR-185	CLIP-seq
MIRT989451	hsa-miR-3150a-3p	CLIP-seq
MIRT989452	hsa-miR-3175	CLIP-seq
MIRT1993227	hsa-miR-3194-3p	CLIP-seq
MIRT1993228	hsa-miR-326	CLIP-seq
MIRT1993229	hsa-miR-330-5p	CLIP-seq
MIRT1993230	hsa-miR-4306	CLIP-seq
MIRT1993231	hsa-miR-4644	CLIP-seq
MIRT1993232	hsa-miR-4667-5p	CLIP-seq
MIRT1993233	hsa-miR-4700-5p	CLIP-seq
MIRT1993234	hsa-miR-637	CLIP-seq
MIRT989458	hsa-miR-939	CLIP-seq
MIRT2227101	hsa-miR-1207-5p	CLIP-seq
MIRT989450	hsa-miR-1225-5p	CLIP-seq
MIRT2227102	hsa-miR-1227	CLIP-seq
MIRT2227103	hsa-miR-1231	CLIP-seq
MIRT1993226	hsa-miR-185	CLIP-seq
MIRT989451	hsa-miR-3150a-3p	CLIP-seq
MIRT989452	hsa-miR-3175	CLIP-seq
MIRT1993227	hsa-miR-3194-3p	CLIP-seq
MIRT1993228	hsa-miR-326	CLIP-seq
MIRT1993229	hsa-miR-330-5p	CLIP-seq
MIRT989453	hsa-miR-34a	CLIP-seq
MIRT989454	hsa-miR-34c-5p	CLIP-seq
MIRT2227104	hsa-miR-4251	CLIP-seq
MIRT2227105	hsa-miR-4288	CLIP-seq
MIRT1993230	hsa-miR-4306	CLIP-seq
MIRT2227106	hsa-miR-4329	CLIP-seq
MIRT989455	hsa-miR-449a	CLIP-seq
MIRT989456	hsa-miR-449b	CLIP-seq
MIRT1993231	hsa-miR-4644	CLIP-seq
MIRT1993232	hsa-miR-4667-5p	CLIP-seq
MIRT2227107	hsa-miR-4687-3p	CLIP-seq
MIRT1993233	hsa-miR-4700-5p	CLIP-seq
MIRT2227108	hsa-miR-4763-3p	CLIP-seq
MIRT2227109	hsa-miR-632	CLIP-seq
MIRT1993234	hsa-miR-637	CLIP-seq
MIRT989458	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA	21873635
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	12351724
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005737	Component	Cytoplasm	IDA	12351724
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0007155	Process	Cell adhesion	ISS
GO:0008092	Function	Cytoskeletal protein binding	IEA
GO:0016322	Process	Neuron remodeling	IDA	12351724
GO:0016601	Process	Rac protein signal transduction	IDA	12351724
GO:0022405	Process	Hair cycle process	IEA
GO:0030316	Process	Osteoclast differentiation	ISS
GO:0031532	Process	Actin cytoskeleton reorganization	ISS
GO:0033623	Process	Regulation of integrin activation	ISS
GO:0050790	Process	Regulation of catalytic activity	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	ISS
GO:0071800	Process	Podosome assembly	ISS

Other IDs

• MIM: 617586
• HGNC: 16460
• e!Ensembl: ENSG00000006607

Protein

• UniProt ID: O94887
• Protein name: FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)
• Protein function: Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast di
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09379	FERM_N	48 → 111	FERM N-terminal domain	Domain
  PF00373	FERM_M	127 → 234	FERM central domain	Domain
  PF09380	FERM_C	238 → 328	FERM C-terminal PH-like domain	Domain
  PF08736	FA	333 → 376	FERM adjacent (FA)	Family
  PF00621	RhoGEF	539 → 724	RhoGEF domain	Domain
  PF00169	PH	756 → 852	PH domain	Domain
  PF00169	PH	930 → 1026	PH domain	Domain

• Sequence:

  MGEIEGTYRVLQTAGMRLGAQTPVGVSTLEPGQTLLPRMQEKHLHLRVKLLDNTMEIFDI
  EPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLA
  VKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDETLD
  REHLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDRE
  GTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLL
  GSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYFKDSGM
  KRIPYERRHSKTHTSVRALTADLPKQSISFPEGLRTPASPSSANAFYSLSPSTLVPSGLP
  EFKDSSSSLTDPQVSYVKSPAAERRSGAVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPS
  PSSRKSPLSLSPAFQVPLGPAEQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIV
  KEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVEQR
  LALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAV
  YKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVT
  TTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSD
  MLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEK
  EKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGH
  GQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFF
  YKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEV
  IQGASSSAGRAPSIVQDGPQPSSGLEGMVRGKEE

• Sequence length: 1054

Pathways

KEGG:

Rap1 signaling pathway
Adherens junction

Reactome:

SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
2q37 deletion syndrome	Chromosome 2q37 deletion syndrome	rs748900140, rs1064797002	19365831
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634	19365831
Nasopharyngeal carcinoma	Nasopharyngeal carcinoma	rs200046052	20512145
Prostate cancer	Malignant neoplasm of prostate, Prostate carcinoma	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	23535732, 29892016, 23535732

Unknown
Disease name	Disease term	dbSNP ID	References
Lymphocytic leukemia	Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma		20062064, 23770605, 23770605
Vitiligo	Vitiligo		27723757