TESPA1 (thymocyte expressed, positive selection associated 1)

Gene

• Entrez ID: 9840
• Gene name: Thymocyte expressed, positive selection associated 1
• Gene symbol: TESPA1
• Synonyms: HSPC257, ITPRID3, KIAA0748
• Chromosome: 12
• Chromosome location: 12q13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017883	hsa-miR-335-5p	Microarray	18185580
MIRT642980	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT642979	hsa-miR-29a-3p	HITS-CLIP	23824327
MIRT642978	hsa-miR-29b-3p	HITS-CLIP	23824327
MIRT642977	hsa-miR-29c-3p	HITS-CLIP	23824327
MIRT642976	hsa-miR-2681-3p	HITS-CLIP	23824327
MIRT642975	hsa-miR-96-3p	HITS-CLIP	23824327
MIRT642974	hsa-miR-8063	HITS-CLIP	23824327
MIRT642973	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT642972	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT642971	hsa-miR-6071	HITS-CLIP	23824327
MIRT642980	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT642979	hsa-miR-29a-3p	HITS-CLIP	23824327
MIRT642978	hsa-miR-29b-3p	HITS-CLIP	23824327
MIRT642977	hsa-miR-29c-3p	HITS-CLIP	23824327
MIRT642976	hsa-miR-2681-3p	HITS-CLIP	23824327
MIRT642975	hsa-miR-96-3p	HITS-CLIP	23824327
MIRT642974	hsa-miR-8063	HITS-CLIP	23824327
MIRT642973	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT642972	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT642971	hsa-miR-6071	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	ISS
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0008180	Component	COP9 signalosome	IDA	22561606
GO:0010387	Process	COP9 signalosome assembly	ISS
GO:0033089	Process	Positive regulation of T cell differentiation in thymus	ISS
GO:0050862	Process	Positive regulation of T cell receptor signaling pathway	IBA	21873635
GO:0050862	Process	Positive regulation of T cell receptor signaling pathway	ISS

Other IDs

• MIM: 615664
• HGNC: 29109
• e!Ensembl: ENSG00000135426

Protein

• UniProt ID: A2RU30
• Protein name: Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1)
• Protein function: Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pa
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14722	KRAP_IP3R_bind	128 → 291	Ki-ras-induced actin-interacting protein-IP3R-interacting domain	Family

• Sequence:

  MEASVLSPTSWEKRRAWLRQSRNWQTQVLEEEAAAALQDVPDPEPSSLDDVFQEGNPINK
  IEDWLQDCGYSEEGFSEEAGQFIYNGFCSHGTSFEDDLTLGAEATLLAANGKLFSRSFLE
  TARPCQLLDLGCSLASSSMTGGTNKTSSSISEILDKVQEDAEDVLFSLGFGQEDHKDTSR
  IPARFFTTPSQAKGIDFQLFLKSQVRRIEMEDPCLMLASRFKQVQTLAVTADAFFCLYSY
  VSKTPVQKFTPSHMFWNCNHPTDVPSIRILSREPEPQSPRDRLRKAISKMCLYTCPRDRP
  PPPHNTPKRNSLDQVVLEVMDKVKEEKQFLQQDSDLGQFSQEDPVPPAEGKKLPTSPYPC
  VFCCEEETQQRMSTVLAPSQTLDSNPKVPCCTHSLPIEDPQWSTDPAQIRRELCSLPATN
  TETHPAKDETFWKRKSRARKSLFQKNLMGRKVKSLDLSITQQKWKQSVDRPELRRSLSQQ
  PQDTFDLEEVQSNSEEEQSQSRWPSRPRHPHHHQTFAGKDS

• Sequence length: 521

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma, Childhood asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	30929738, 31036433, 30929738

Unknown
Disease name	Disease term	dbSNP ID	References
Eczema	Eczema		30595370