Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
9833 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Maternal embryonic leucine zipper kinase |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
MELK |
SynonymsGene synonyms aliases
|
HPK38 |
ChromosomeChromosome number
|
9 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
9p13.2 |
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
Q14680 |
Protein name |
Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) |
Protein function |
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622 |
PDB |
4BKY
,
4BKZ
,
4BL1
,
4D2P
,
4D2T
,
4D2V
,
4D2W
,
4IXP
,
4UMP
,
4UMQ
,
4UMR
,
4UMT
,
4UMU
,
5IH8
,
5IH9
,
5IHA
,
5IHC
,
5K00
,
5M5A
,
5MAF
,
5MAG
,
5MAH
,
5MAI
,
5TVT
,
5TWL
,
5TWU
,
5TWY
,
5TWZ
,
5TX3
,
6GVX
,
6VXR
,
9F31
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00069 |
Pkinase |
11 → 263 |
Protein kinase domain |
Domain |
PF02149 |
KA1 |
607 → 651 |
Kinase associated domain 1 |
Domain |
|
Sequence |
|
Sequence length |
651 |
Interactions |
View interactions |
Associated diseases
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Liver carcinoma |
Liver carcinoma |
|
28284560 |
Ovarian adenocarcinoma |
Ovarian Mucinous Adenocarcinoma |
|
|
|