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MELK (maternal embryonic leucine zipper kinase)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9833
Gene nameGene Name - the full gene name approved by the HGNC.
Maternal embryonic leucine zipper kinase
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
MELK
SynonymsGene synonyms aliases
HPK38
ChromosomeChromosome number
9
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9p13.2
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016391 hsa-miR-193b-3p Microarray 20304954
MIRT628572 hsa-miR-106a-5p HITS-CLIP 23824327
MIRT628571 hsa-miR-106b-5p HITS-CLIP 23824327
MIRT628570 hsa-miR-17-5p HITS-CLIP 23824327
MIRT628569 hsa-miR-20a-5p HITS-CLIP 23824327
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle TAS 12400006
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 12400006, 15908796, 16216881, 17280616
GO:0004715 Function Non-membrane spanning protein tyrosine kinase activity IBA 21873635
GO:0004715 Function Non-membrane spanning protein tyrosine kinase activity IDA 16216881
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q14680
Protein name Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2)
Protein function Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622
PDB 4BKY , 4BKZ , 4BL1 , 4D2P , 4D2T , 4D2V , 4D2W , 4IXP , 4UMP , 4UMQ , 4UMR , 4UMT , 4UMU , 5IH8 , 5IH9 , 5IHA , 5IHC , 5K00 , 5M5A , 5MAF , 5MAG , 5MAH , 5MAI , 5TVT , 5TWL , 5TWU , 5TWY , 5TWZ , 5TX3 , 6GVX , 6VXR , 9F31
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase
11 263
Protein kinase domain
Domain
PF02149 KA1
607 651
Kinase associated domain 1
Domain
Sequence
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWI
MQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
Sequence length 651
Interactions View interactions
Associated diseases
Unknown
Disease name Disease term dbSNP ID References
Liver carcinoma Liver carcinoma 28284560
Ovarian adenocarcinoma Ovarian Mucinous Adenocarcinoma

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