ARHGEF11 (Rho guanine nucleotide exchange factor 11)

Gene

• Entrez ID: 9826
• Gene name: Rho guanine nucleotide exchange factor 11
• Gene symbol: ARHGEF11
• Synonyms: GTRAP48, PDZ-RHOGEF
• Chromosome: 1
• Chromosome location: 1q23.1
• Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A sim

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT707303	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707302	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT707301	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707300	hsa-miR-3924	HITS-CLIP	21572407
MIRT707299	hsa-miR-6083	HITS-CLIP	21572407
MIRT707298	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT707303	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707302	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT707301	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707300	hsa-miR-3924	HITS-CLIP	21572407
MIRT707299	hsa-miR-6083	HITS-CLIP	21572407
MIRT707298	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT795308	hsa-miR-139-5p	CLIP-seq
MIRT795309	hsa-miR-2110	CLIP-seq
MIRT795310	hsa-miR-3977	CLIP-seq
MIRT795311	hsa-miR-4271	CLIP-seq
MIRT795312	hsa-miR-4420	CLIP-seq
MIRT795313	hsa-miR-4725-3p	CLIP-seq
MIRT795314	hsa-miR-491-5p	CLIP-seq
MIRT795315	hsa-miR-548c-3p	CLIP-seq
MIRT795316	hsa-miR-299-3p	CLIP-seq
MIRT795317	hsa-miR-3151	CLIP-seq
MIRT795318	hsa-miR-3177-5p	CLIP-seq
MIRT795319	hsa-miR-329	CLIP-seq
MIRT795320	hsa-miR-338-3p	CLIP-seq
MIRT795321	hsa-miR-338-5p	CLIP-seq
MIRT795322	hsa-miR-342-5p	CLIP-seq
MIRT795323	hsa-miR-3613-3p	CLIP-seq
MIRT795324	hsa-miR-3616-3p	CLIP-seq
MIRT795325	hsa-miR-362-3p	CLIP-seq
MIRT795326	hsa-miR-3941	CLIP-seq
MIRT795327	hsa-miR-3973	CLIP-seq
MIRT795328	hsa-miR-3974	CLIP-seq
MIRT795329	hsa-miR-4310	CLIP-seq
MIRT795330	hsa-miR-4436b-3p	CLIP-seq
MIRT795331	hsa-miR-4447	CLIP-seq
MIRT795332	hsa-miR-4472	CLIP-seq
MIRT795333	hsa-miR-4481	CLIP-seq
MIRT795334	hsa-miR-4488	CLIP-seq
MIRT795335	hsa-miR-4491	CLIP-seq
MIRT795336	hsa-miR-4530	CLIP-seq
MIRT795337	hsa-miR-4651	CLIP-seq
MIRT795338	hsa-miR-4657	CLIP-seq
MIRT795339	hsa-miR-4664-5p	CLIP-seq
MIRT795340	hsa-miR-4697-5p	CLIP-seq
MIRT795341	hsa-miR-4699-3p	CLIP-seq
MIRT795342	hsa-miR-4710	CLIP-seq
MIRT795343	hsa-miR-4721	CLIP-seq
MIRT795344	hsa-miR-4745-5p	CLIP-seq
MIRT795345	hsa-miR-4758-5p	CLIP-seq
MIRT795346	hsa-miR-4789-3p	CLIP-seq
MIRT795347	hsa-miR-4792	CLIP-seq
MIRT795314	hsa-miR-491-5p	CLIP-seq
MIRT795348	hsa-miR-520g	CLIP-seq
MIRT795349	hsa-miR-520h	CLIP-seq
MIRT795350	hsa-miR-548p	CLIP-seq
MIRT795351	hsa-miR-591	CLIP-seq
MIRT795352	hsa-miR-603	CLIP-seq
MIRT795353	hsa-miR-608	CLIP-seq
MIRT795354	hsa-miR-766	CLIP-seq
MIRT795355	hsa-miR-873	CLIP-seq
MIRT1934815	hsa-miR-516b	CLIP-seq
MIRT795308	hsa-miR-139-5p	CLIP-seq
MIRT1934816	hsa-miR-1972	CLIP-seq
MIRT795309	hsa-miR-2110	CLIP-seq
MIRT1934817	hsa-miR-3678-5p	CLIP-seq
MIRT795310	hsa-miR-3977	CLIP-seq
MIRT795311	hsa-miR-4271	CLIP-seq
MIRT795329	hsa-miR-4310	CLIP-seq
MIRT795312	hsa-miR-4420	CLIP-seq
MIRT795333	hsa-miR-4481	CLIP-seq
MIRT795342	hsa-miR-4710	CLIP-seq
MIRT1934818	hsa-miR-4716-3p	CLIP-seq
MIRT795313	hsa-miR-4725-3p	CLIP-seq
MIRT795344	hsa-miR-4745-5p	CLIP-seq
MIRT795314	hsa-miR-491-5p	CLIP-seq
MIRT1934816	hsa-miR-1972	CLIP-seq
MIRT2174599	hsa-miR-3150a-3p	CLIP-seq
MIRT2174600	hsa-miR-3175	CLIP-seq
MIRT795324	hsa-miR-3616-3p	CLIP-seq
MIRT795326	hsa-miR-3941	CLIP-seq
MIRT2174601	hsa-miR-4270	CLIP-seq
MIRT795330	hsa-miR-4436b-3p	CLIP-seq
MIRT2174602	hsa-miR-4441	CLIP-seq
MIRT2174603	hsa-miR-4468	CLIP-seq
MIRT2174604	hsa-miR-4654	CLIP-seq
MIRT795343	hsa-miR-4721	CLIP-seq
MIRT2174605	hsa-miR-4769-5p	CLIP-seq
MIRT795314	hsa-miR-491-5p	CLIP-seq
MIRT2174606	hsa-miR-664	CLIP-seq
MIRT795355	hsa-miR-873	CLIP-seq
MIRT2174607	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001558	Process	Regulation of cell growth	NAS	10026210
GO:0001664	Function	G protein-coupled receptor binding	IDA	15755723
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS	10026210
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	10026210, 15530360, 17474147, 20300064, 20844236, 21988832, 28514442
GO:0005737	Component	Cytoplasm	IDA	15755723
GO:0005829	Component	Cytosol	TAS
GO:0006941	Process	Striated muscle contraction	NAS	10026210
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	15755723
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	10026210
GO:0007266	Process	Rho protein signal transduction	IDA	10026210
GO:0016020	Component	Membrane	IEA
GO:0030010	Process	Establishment of cell polarity	NAS	10026210
GO:0030036	Process	Actin cytoskeleton organization	NAS	10026210
GO:0043065	Process	Positive regulation of apoptotic process	TAS
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	10026210
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

Other IDs

• MIM: 605708
• HGNC: 14580
• e!Ensembl: ENSG00000132694

Protein

• UniProt ID: O15085
• Protein name: Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF)
• Protein function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and G
• PDB: 1HTJ, 1XCG, 2DLS, 3KZ1, 3T06, 5E6P, 5JHG, 5JHH, 5TYT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00595	PDZ	47 → 120	PDZ domain	Domain
  PF09128	RGS-like	307 → 486	Regulator of G protein signalling-like domain	Domain
  PF00621	RhoGEF	738 → 921	RhoGEF domain	Domain
  PF17838	PH_16	950 → 1079	PH domain	Domain

• Sequence:

  MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFT
  VSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL
  GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQ
  ILRNMLRQEEKELQDILPLYGDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNR
  NSVLSDPGLDSPRTSPVIMARVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDP
  GYFNNESDIIFQDLEKLKSRPAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSL
  GKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYR
  TKRTLGLGSLYGENDLLDLDGDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYM
  SHAGIRLREARPSNTAEKAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYI
  GKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLES
  DSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLS
  TRSLENPTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTV
  GKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFP
  NLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL
  ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT
  SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD
  LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ
  TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN
  ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ
  GKHQVLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADS
  ALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGG
  EGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGY
  KVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAP
  MSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLK
  DMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPC
  PEDGSDAPLEDSTADAAASPGP

• Sequence length: 1522

Pathways

KEGG:

Vascular smooth muscle contraction
Parathyroid hormone synthesis, secretion and action
Pathogenic Escherichia coli infection
Human cytomegalovirus infection
Pathways in cancer

Reactome:

NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	25319871, 18678470